ANDR_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANDR_MOUSE
• UniProt AC: P19091
• Protein Name: Androgen receptor
• Gene Name: Ar
• Organism: Mus musculus (Mouse).
• Sequence Length: 899
• Subcellular Localization: Nucleus . Cytoplasm . Detected at the promoter of target genes. Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of RACK1.
• Protein Description: Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3..
• Protein Sequence: MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREAIQNPGPRHPEAANIAPPGACLQQRQETSPRRRRRQQHTEDGSPQAHIRGPTGYLALEEEQQPSQQQAASEGHPESSCLPEPGAATAPGKGLPQQPPAPPDQDDSAAPSTLSLLGPTFPGLSSCSADIKDILNEAGTMQLLQQQQQQQQHQQQHQQHQQQQEVISEGSSARAREATGAPSSSKDSYLGGNSTISDSAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYASLLGGPPAVRPTPCAPLPECKGLPLDEGPGKSTEETAEYSSFKGGYAKGLEGESLGCSGSSEAGSSGTLEIPSSLSLYKSGALDEAAAYQNRDYYNFPLALSGPPHPPPPTHPHARIKLENPLDYGSAWAAAAAQCRYGDLGSLHGGSVAGPSTGSPPATTSSSWHTLFTAEEGQLYGPGGGGGSSSPSDAGPVAPYGYTRPPQGLTSQESDYSASEVWYPGGVVNRVPYPSPNCVKSEMGPWMENYSGPYGDMRLDSTRDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGENSNAGSPTEDPSQKMTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	Phosphorylation	LQQRQETSPRRRRRQ HHHHHCCCHHHHHHH	18.69	-
71	Phosphorylation	RRRRQQHTEDGSPQA HHHHHHHCCCCCCCC	31.28	27566939
75	Phosphorylation	QQHTEDGSPQAHIRG HHHCCCCCCCCCCCC	26.59	25521595
218	Phosphorylation	PSSSKDSYLGGNSTI CCCCCCCCCCCCCCC	21.35	-
251	Phosphorylation	VEALEHLSPGEQLRG HHHHHHCCCCCCCCC	32.54	-
262	Phosphorylation	QLRGDCMYASLLGGP CCCCCHHHHHHHCCC	10.20	-
302	Phosphorylation	STEETAEYSSFKGGY CHHHHHHHHHCCCCC	13.72	-
341	Phosphorylation	IPSSLSLYKSGALDE CCCCHHHHHCCCCCH	10.34	-
352	Phosphorylation	ALDEAAAYQNRDYYN CCCHHHHHCCCCCCC	11.12	-
357	Phosphorylation	AAYQNRDYYNFPLAL HHHCCCCCCCCCCCC	9.32	-
358	Phosphorylation	AYQNRDYYNFPLALS HHCCCCCCCCCCCCC	18.02	-
388	Phosphorylation	KLENPLDYGSAWAAA ECCCCCCHHHHHHHH	22.21	-
514	Phosphorylation	MENYSGPYGDMRLDS HHCCCCCCCCCCCCC	29.32	-
531	Phosphorylation	DHVLPIDYYFPPQKT CCEECCCEECCCCCE	14.02	-
626	Phosphorylation	LQEEGENSNAGSPTE CCCCCCCCCCCCCCC	24.61	29899451
630	Phosphorylation	GENSNAGSPTEDPSQ CCCCCCCCCCCCHHH	26.66	25521595
632	Phosphorylation	NSNAGSPTEDPSQKM CCCCCCCCCCHHHCC	55.51	29472430
636	Phosphorylation	GSPTEDPSQKMTVSH CCCCCCHHHCCCHHH	55.55	29472430
700	Ubiquitination	VHVVKWAKALPGFRN HHHHHHHHCCCCCCC	49.71	-
864	Phosphorylation	TFDLLIKSHMVSVDF HHHHHHHHCCCCCCH	15.15	29233185
868	Phosphorylation	LIKSHMVSVDFPEMM HHHHCCCCCCHHHHH	14.37	29233185
880	Phosphorylation	EMMAEIISVQVPKIL HHHHHHHHCCCCHHH	16.50	29233185
895	Phosphorylation	SGKVKPIYFHTQ--- CCCCEEEEEECC---	9.61	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
61	S	Phosphorylation	Kinase	CDK9	Q99J95	Uniprot
218	Y	Phosphorylation	Kinase	CSK	P41241	Uniprot
262	Y	Phosphorylation	Kinase	TNK2	O54967	Uniprot
262	Y	Phosphorylation	Kinase	CSK	P41241	Uniprot
302	Y	Phosphorylation	Kinase	CSK	P41241	Uniprot
341	Y	Phosphorylation	Kinase	CSK	P41241	Uniprot
352	Y	Phosphorylation	Kinase	CSK	P41241	Uniprot
357	Y	Phosphorylation	Kinase	CSK	P41241	Uniprot
358	Y	Phosphorylation	Kinase	TNK2	O54967	Uniprot
358	Y	Phosphorylation	Kinase	CSK	P41241	Uniprot
388	Y	Phosphorylation	Kinase	CSK	P41241	Uniprot
514	Y	Phosphorylation	Kinase	CSK	P41241	Uniprot
531	Y	Phosphorylation	Kinase	CSK	P41241	Uniprot
895	Y	Phosphorylation	Kinase	CSK	P41241	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	Mdm2	P23804	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	Rnf6	Q9DBU5	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
6	K	ubiquitylation	'Lys-6' and 'Lys-27'-linked polyubiquitination by RNF6 modulates AR transcriptional activity and specificity (By similarity).	-
61	S	Phosphorylation	Phosphorylation at Ser-61 by CDK9 regulates AR promoter selectivity and cell growth.	-
381	K	Sumoylation	Sumoylated on Lys-381 (major) and Lys-500 (By similarity).	-
500	K	Sumoylation	Sumoylated on Lys-381 (major) and Lys-500 (By similarity).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANDR_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NCOA2_MOUSE	Ncoa2	physical	20211142
PO2F1_MOUSE	Pou2f1	physical	20211142
TLX3_MOUSE	Tlx3	physical	20211142
CLF2A_MOUSE	Cmtm2a	physical	14576337
KDM1A_MOUSE	Kdm1a	physical	16079795
SMRC1_HUMAN	SMARCC1	physical	15923603
TCF21_MOUSE	Tcf21	physical	15919722
ATRX_MOUSE	Atrx	physical	21427128
KDM4C_MOUSE	Kdm4c	physical	17277772
ACTN2_MOUSE	Actn2	physical	15072553
GRP78_MOUSE	Hspa5	physical	23618905
SQSTM_MOUSE	Sqstm1	physical	23637164
CUX1_HUMAN	CUX1	physical	26496610
CASP_HUMAN	CUX1	physical	26496610
TAP1_HUMAN	TAP1	physical	26496610
FAF2_HUMAN	FAF2	physical	26496610
P5CR2_HUMAN	PYCR2	physical	26496610
PTCD3_HUMAN	PTCD3	physical	26496610
CR021_HUMAN	C18orf21	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.