KDM4C_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KDM4C_MOUSE
• UniProt AC: Q8VCD7
• Protein Name: Lysine-specific demethylase 4C
• Gene Name: Kdm4c
• Organism: Mus musculus (Mouse).
• Sequence Length: 1054
• Subcellular Localization: Nucleus .
• Protein Description: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate (By similarity)..
• Protein Sequence: MEVVEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPRQCYDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSSKYCTPRYLDYEDLERKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFLRHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLCTCRNDMVKISMDIFVKKFQPDRYQIWKQGKDIYTIDHTKPTPESTPEVKTWLQRKKKLRKPPKSLQGNKPLCKRPKPEEDEEFAEFSGEEGANPAMGPRHLKVTEKPEKALKLGKLEESSAKEALDTRIQVDQSLLNDTKLSGKGCISSSVTAEIPPEDNRASAVISPSQLKEGADCIPLSHGHQAGKESHLLKILKLESPKIPSPLPESNKVLTEGEENDEEGHGSNLEPGEIPEALSEERNGLNIPKIIEGQPKTTKSWRHPLGKPPARSPMTLVKQQVASDEELPEVLSIDEEVEETESWAKPLIHLWQTKSPNFMAEQEYNATVAKMEPNCAICTLLMPYYKPDSSKEENDSRWETAVNEVVQSGRKTKPIIPEMCFIYSEENVDYSPPNAFLEEDGTSLLISCAKCFVRVHASCYGVPSHEVCDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNQWAHVICAVAVPEVRFTNVPERTQIDVDRIPLQRLKLKCIFCRHRVKKVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVNITCFRHRVNSNAKSKTCEKAISVGQTVITKHRNTRYYSCRVIDVTSQTFYEVMFDDGSFSRDTFPEDIVSRNCVKLGPPAEGEVIQVKWPDGKLYGAKYLGSNVAYMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADVIQGERKRQRVLSSRLKNEYVDDPVYRTFLKSSFQKKCQKRQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
395	Phosphorylation	DEEFAEFSGEEGANP CHHHHHHCCCCCCCC	36.48	26824392
471	Phosphorylation	PPEDNRASAVISPSQ CCCCCCCCEECCHHH	21.60	28833060
475	Phosphorylation	NRASAVISPSQLKEG CCCCEECCHHHHHCC	16.35	26824392
477	Phosphorylation	ASAVISPSQLKEGAD CCEECCHHHHHCCCC	41.16	28833060
508	Phosphorylation	LKILKLESPKIPSPL HHHHHCCCCCCCCCC	41.76	25266776
513	Phosphorylation	LESPKIPSPLPESNK CCCCCCCCCCCCCCC	42.41	25266776
518	Phosphorylation	IPSPLPESNKVLTEG CCCCCCCCCCCCCCC	39.76	26643407
523	Phosphorylation	PESNKVLTEGEENDE CCCCCCCCCCCCCCC	44.95	25338131
525	Phosphorylation	SNKVLTEGEENDEEG CCCCCCCCCCCCCCC	42.13	24719451
535	Phosphorylation	NDEEGHGSNLEPGEI CCCCCCCCCCCCCCC	32.35	25338131
591	Phosphorylation	LVKQQVASDEELPEV HHHHHCCCCCCCCCC	46.85	25338131
623	Phosphorylation	IHLWQTKSPNFMAEQ HHHHHCCCCCCHHHH	28.59	22006019
878	Phosphorylation	KTCEKAISVGQTVIT CCHHHHHHCCCEEEE	25.67	22871156
885	Phosphorylation	SVGQTVITKHRNTRY HCCCEEEECCCCCCE	19.23	22871156
889	Phosphorylation	TVITKHRNTRYYSCR EEEECCCCCCEEEEE	28.73	24719451
890	Phosphorylation	VITKHRNTRYYSCRV EEECCCCCCEEEEEE	21.72	-
902	Phosphorylation	CRVIDVTSQTFYEVM EEEEECCCCEEEEEE	27.37	24719451
998	Phosphorylation	RVKARFSTASDMRFE HHHHHCCCCCCCCCC	27.71	-
1025	Phosphorylation	RKRQRVLSSRLKNEY HHHHHHHHHHHCCCC	15.56	21454597
1043	Phosphorylation	PVYRTFLKSSFQKKC HHHHHHHHHHHHHHH	39.60	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KDM4C_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KDM4C_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KDM4C_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ESR1_MOUSE	Esr1	physical	21445275
SMCA4_MOUSE	Smarca4	physical	21445275
ANDR_MOUSE	Ar	physical	17277772
H31T_HUMAN	HIST3H3	physical	17277772

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.