dbPTM

ATRX_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ATRX_MOUSE
UniProt AC	Q61687
Protein Name	Transcriptional regulator ATRX
Gene Name	Atrx
Organism	Mus musculus (Mouse).
Sequence Length	2476
Subcellular Localization	Nucleus. Chromosome, telomere. Nucleus, PML body. Associated with pericentromeric heterochromatin during interphase and mitosis, probably by interacting with CBX5/HP1 alpha. Colocalizes with histone H3.3, DAXX, HIRA and ASF1A at PML-nuclear bodies (B
Protein Description	Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells probably implying recruitment of CBX5 to telomers. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according. [PubMed: 20211137) is required for its transcriptional repression in embryonic stem cells. Acts as negative regulator of chromatin incorporation of transcriptionally repressive histone H2AFY, particularily at telomeres. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (By similarity]
Protein Sequence	MTAEPMSGNKLSTLVQKLHDFLAHSSEESEETCSSPRLVMNQSTDKICGSGLNSDMMENNKEEGASTSEKSRSSGSSRSKRKPSIVTKYVESDDEKPTDENVNEKAATENSENDITMQSLPKGTVIVQPEPVLNEDKDDFKGPEFRSRSKMKADNLKKRGEDGLHGIVSCTACGQQVNHFQKDSIYRHPSLKVLICKNCFKYYMSDDISRDSDGMDEQCRWCAEGGNLICCDFCHNAFCKKCILRNLGRKELSTIMDENNQWYCYICQPEPLLDLVTACNSVFENLEQLLQQNKKKIKVDSEKTSKVCDQTSKFSPKKSSSSCNGEEKKLEESCSGSVSSTYSHSALSVPKEMIKKTTKLIETTSNMNSSYIKFLKQAADNSEMTSAMKLCQLKSFKSVLDDIKKAHLALEEDLNSEIQALDDVHKEKNTKDLKSTDAKSETKLGKGEKSYSTEKREFLKLDARSSVKAIDGEEQRAHKSTSGEHKGSGRKDGSQYEPTNTPEDLDMDIVSVPSSVPEDIFDSLESAMEVQSSADYQGDGNSGTEPELESSSVKLNVSSKDSRGNIKSKVTAKVRKELFVKLTPVSLSNSPIKGVDCQEVSQEKNGRKSSGVARSSEKCRPREEISDHENNVTILLEDSDLRRSPRVKTTPLRRQTESNPAMSNSDEESNGTMKEKQKMSGPIRKKDKRNSADCATDNPKPHKVPKAKQPVIGDQNSDSDEMLAVLKEASQMGHSSSSDTDINEPQMNHKGKTGKDDNGKRKRKNSTSGSDFDTKKGKSTETSIISKKKRQNYSESSNYDSELEREIKTMSRIGAARKSVPEKKEEDSSEDEKQGKKVVDNGGHERAKTTQEGSSADDTGDTEGRQGGSCSIAGGSIEKVRSGVEFREMLCKPGVSSDGAEKPSVKEENVNSPEDKRVSKTKEKTKHLRSRQSRKGKGGSSDGTDRFPKKEQSDESSEGEKKQSRQRPGTKGKKAPDLKGETLKREQEWDSSSDGTERLPEEEEIGPFSKGIKQSKTDTAGGEKKGKKWKDKSCEKKEELSDSVDKLPGKGDSCDSSEDKKTRNRVSLREKKRFSLPAKSPGKRPECSSSDTEKSLKGQCCDSTEKRPKRIDLRERRNSSSKRNTKEVKSASSSSDAEGSSEDNKKQKKQRTSAKKKTGNTKEKKRNSLRATPKRKQVDITSSSSDIGDDDQNSAGEESSDEQKIKPVTENLVLPSHTGFCQSSGDEALSKSVPATVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPDGGGKKRIGKQSEESPADDGELRREQLAVNQVNSESDSDSEESKKPRYRHRLLRHKLTLSDGESGEEKPTKPKEHKEAKGRNRRKVSSEDSEDTDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSHSEEDKKEGDEEDEEDEDEDEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDENEETKEPLVQVHRNMVIKLKPHQVDGVQFMWDCCCESVEKTKKSPGSGCILAHCMGLGKTLQVVSFLHTVLLCDKLDFSTALVVCPLNTALNWMNEFEKWQEGLNDNEKLEVSELATVKRPQERSYMLQRWQEDGGVMIIGYEMYRNLAQGRNVKSRKLKDIFNKALVDPGPDFVVCDEGHILKNEASAVSKAMNSIKSRRRIILTGTPLQNNLIEYHCMVNFIKENLLGSIKEFRNRFINPIQNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYTALTKFLPPKHEYVLAVRMTAIQCKLYQYYLDHLTGVGNSTEGGRGKAGAKLFQDFQMLSRIWTHPWCLQLDYISKENKGYFDEDSMDEFIASDSDETSKSLSSDEKKKPKGKKGKKDSSSSGSGSDNDVEVIKVWNSRSRGGGDGNVDDTGNNPSVSLKLDESKTTSTSNPSSPAPDWYKDFVTDTDAEVLEHSGKMVLLFEILRMAEEIGDKVLVFSQSLISLDLIEDFLELASREKTEDKEKPLIYKGEGKWIRNIDYYRLDGSTNAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAANRVIIFDASWNPSYDIQSIFRVYRFGQTKPVYVYRFLAQGTMEDKIYDRQVTKQSLSFRVVDQQQVERHFTMNELTELYTFEPDLLDDPNSEKKKKRDTPMLPKDTILAELLQIHKEHIVGYHEHDSLLDHKEEEELTEEERKAAWAEYEAEKKGLTMRFNIPTGTNLPPVTFTSQTPYIPFNLGALSAMSNQQLEDLINQGREKVVEATNSMTAVRIQPLEDIISTVWKENMNLSEAQVQALALSRQASQELDVKRREAIYNDVLTKQQMLINCVQRILMNRRLQQQYTQQQQQQLTYQQATLSHLMMPKPPNLIMTPSNYQQIDMRGMYQSVAGGMQPPPLQRAPPPTVRSKNPGPSPGKSM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	LHDFLAHSSEESEET HHHHHHCCCHHHHHH	33.56	25619855
26	Phosphorylation	HDFLAHSSEESEETC HHHHHCCCHHHHHHC	35.20	25619855
29	Phosphorylation	LAHSSEESEETCSSP HHCCCHHHHHHCCCC	36.36	25619855
32	Phosphorylation	SSEESEETCSSPRLV CCHHHHHHCCCCCEE	17.40	25619855
34	Phosphorylation	EESEETCSSPRLVMN HHHHHHCCCCCEEEC	51.28	25619855
35	Phosphorylation	ESEETCSSPRLVMNQ HHHHHCCCCCEEECC	19.04	25619855
43	Phosphorylation	PRLVMNQSTDKICGS CCEEECCCCCCCCCC	33.30	25266776
44	Phosphorylation	RLVMNQSTDKICGSG CEEECCCCCCCCCCC	31.39	25266776
50	O-linked_Glycosylation	STDKICGSGLNSDMM CCCCCCCCCCCHHHH	35.38	50567861
50	Phosphorylation	STDKICGSGLNSDMM CCCCCCCCCCCHHHH	35.38	25777480
54	Phosphorylation	ICGSGLNSDMMENNK CCCCCCCHHHHHCCC	31.74	25777480
66	Phosphorylation	NNKEEGASTSEKSRS CCCCCCCCCCHHHHC	43.24	25777480
67	Phosphorylation	NKEEGASTSEKSRSS CCCCCCCCCHHHHCC	40.13	25777480
68	Phosphorylation	KEEGASTSEKSRSSG CCCCCCCCHHHHCCC	40.30	25777480
71	Phosphorylation	GASTSEKSRSSGSSR CCCCCHHHHCCCCCC	33.09	25777480
79	Phosphorylation	RSSGSSRSKRKPSIV HCCCCCCCCCCCCEE	38.47	27600695
84	Phosphorylation	SRSKRKPSIVTKYVE CCCCCCCCEEEEEEC	32.50	26824392
87	Phosphorylation	KRKPSIVTKYVESDD CCCCCEEEEEECCCC	18.26	25159016
89	Phosphorylation	KPSIVTKYVESDDEK CCCEEEEEECCCCCC	10.49	24925903
92	Phosphorylation	IVTKYVESDDEKPTD EEEEEECCCCCCCCC	40.07	24925903
98	Phosphorylation	ESDDEKPTDENVNEK CCCCCCCCCCCHHHH	67.99	24925903
108	Phosphorylation	NVNEKAATENSENDI CHHHHHHCCCCCCCC	40.33	26239621
111	Phosphorylation	EKAATENSENDITMQ HHHHCCCCCCCCEEE	31.38	27087446
116	Phosphorylation	ENSENDITMQSLPKG CCCCCCCEEECCCCC	16.42	25266776
119	Phosphorylation	ENDITMQSLPKGTVI CCCCEEECCCCCCEE	35.50	28066266
202	Phosphorylation	ICKNCFKYYMSDDIS EECCCHHHHCCCCCC	5.55	27087446
205	Phosphorylation	NCFKYYMSDDISRDS CCHHHHCCCCCCCCC	18.93	23984901
209	Phosphorylation	YYMSDDISRDSDGMD HHCCCCCCCCCCCCH	36.71	23684622
212	Phosphorylation	SDDISRDSDGMDEQC CCCCCCCCCCCHHHH	34.65	25521595
311	Phosphorylation	TSKVCDQTSKFSPKK HHHHCCCCCCCCCCC	22.19	25619855
312	Phosphorylation	SKVCDQTSKFSPKKS HHHCCCCCCCCCCCC	26.52	23684622
315	Phosphorylation	CDQTSKFSPKKSSSS CCCCCCCCCCCCCCC	39.28	23527152
319	Phosphorylation	SKFSPKKSSSSCNGE CCCCCCCCCCCCCCC	41.39	21659604
320	Phosphorylation	KFSPKKSSSSCNGEE CCCCCCCCCCCCCCH	34.84	25521595
321	Phosphorylation	FSPKKSSSSCNGEEK CCCCCCCCCCCCCHH	46.10	25521595
322	Phosphorylation	SPKKSSSSCNGEEKK CCCCCCCCCCCCHHH	17.35	25195567
333	Phosphorylation	EEKKLEESCSGSVSS CHHHHHHHCCCCCCC	12.28	22817900
335	Phosphorylation	KKLEESCSGSVSSTY HHHHHHCCCCCCCCC	43.30	22817900
337	Phosphorylation	LEESCSGSVSSTYSH HHHHCCCCCCCCCCC	11.52	22817900
339	Phosphorylation	ESCSGSVSSTYSHSA HHCCCCCCCCCCCCC	20.75	22817900
357	Phosphorylation	PKEMIKKTTKLIETT CHHHHHHHHHHHHHH	24.94	-
416	Phosphorylation	ALEEDLNSEIQALDD HHHHHHHHHHHHHHH	43.29	25338131
450	Phosphorylation	KLGKGEKSYSTEKRE CCCCCCCCCCHHHHH	21.73	22871156
452	Phosphorylation	GKGEKSYSTEKREFL CCCCCCCCHHHHHHH	36.86	29514104
465	Phosphorylation	FLKLDARSSVKAIDG HHHHHCHHCCEECCC	41.00	29176673
466	Phosphorylation	LKLDARSSVKAIDGE HHHHCHHCCEECCCC	23.29	29176673
558	Phosphorylation	SSVKLNVSSKDSRGN CEEEEEECCCCCCCC	30.51	24719451
562	Phosphorylation	LNVSSKDSRGNIKSK EEECCCCCCCCCCHH	45.91	25338131
583	Phosphorylation	KELFVKLTPVSLSNS HHHEEEEEECCCCCC	18.87	24925903
586	Phosphorylation	FVKLTPVSLSNSPIK EEEEEECCCCCCCCC	27.55	24925903
588	Phosphorylation	KLTPVSLSNSPIKGV EEEECCCCCCCCCCC	27.96	24925903
590	Phosphorylation	TPVSLSNSPIKGVDC EECCCCCCCCCCCCH	25.32	27087446
601	Phosphorylation	GVDCQEVSQEKNGRK CCCHHHHHHHHCCCC	31.69	25619855
610	Phosphorylation	EKNGRKSSGVARSSE HHCCCCCCCCCCCCC	40.08	23375375
626	Phosphorylation	CRPREEISDHENNVT CCCHHHHCCCCCCEE	35.87	27087446
633	Phosphorylation	SDHENNVTILLEDSD CCCCCCEEEEEECCC	14.18	21082442
639	Phosphorylation	VTILLEDSDLRRSPR EEEEEECCCCCCCCC	29.21	26643407
644	Phosphorylation	EDSDLRRSPRVKTTP ECCCCCCCCCCCCCC	15.60	26239621
649	Phosphorylation	RRSPRVKTTPLRRQT CCCCCCCCCCCCCCC	30.68	28418008
650	Phosphorylation	RSPRVKTTPLRRQTE CCCCCCCCCCCCCCC	18.01	25159016
656	Phosphorylation	TTPLRRQTESNPAMS CCCCCCCCCCCCCCC	39.30	21149613
658	Phosphorylation	PLRRQTESNPAMSNS CCCCCCCCCCCCCCC	52.05	22324799
663	Phosphorylation	TESNPAMSNSDEESN CCCCCCCCCCCHHCC	34.98	27087446
665	Phosphorylation	SNPAMSNSDEESNGT CCCCCCCCCHHCCCC	38.81	25521595
669	Phosphorylation	MSNSDEESNGTMKEK CCCCCHHCCCCCCHH	38.21	27087446
672	Phosphorylation	SDEESNGTMKEKQKM CCHHCCCCCCHHHHC	29.35	22324799
691	Phosphorylation	RKKDKRNSADCATDN CCCCCCCCCCCCCCC	29.53	26824392
696	Phosphorylation	RNSADCATDNPKPHK CCCCCCCCCCCCCCC	42.51	25266776
717	Phosphorylation	PVIGDQNSDSDEMLA CCCCCCCCCHHHHHH	32.62	24925903
719	Phosphorylation	IGDQNSDSDEMLAVL CCCCCCCHHHHHHHH	34.98	27087446
730	Phosphorylation	LAVLKEASQMGHSSS HHHHHHHHHCCCCCC	23.07	29472430
735	Phosphorylation	EASQMGHSSSSDTDI HHHHCCCCCCCCCCC	26.62	23684622
736	Phosphorylation	ASQMGHSSSSDTDIN HHHCCCCCCCCCCCC	28.34	23684622
737	Phosphorylation	SQMGHSSSSDTDINE HHCCCCCCCCCCCCC	34.94	23684622
738	Phosphorylation	QMGHSSSSDTDINEP HCCCCCCCCCCCCCC	46.61	25266776
740	Phosphorylation	GHSSSSDTDINEPQM CCCCCCCCCCCCCCC	40.50	23684622
766	Phosphorylation	GKRKRKNSTSGSDFD CCCCCCCCCCCCCCC	27.30	27087446
767	Phosphorylation	KRKRKNSTSGSDFDT CCCCCCCCCCCCCCC	46.64	27087446
768	Phosphorylation	RKRKNSTSGSDFDTK CCCCCCCCCCCCCCC	35.80	27087446
770	Phosphorylation	RKNSTSGSDFDTKKG CCCCCCCCCCCCCCC	34.57	27087446
774	Phosphorylation	TSGSDFDTKKGKSTE CCCCCCCCCCCCCCC	34.35	25159016
778	Acetylation	DFDTKKGKSTETSII CCCCCCCCCCCHHHH	64.18	23806337
779	Phosphorylation	FDTKKGKSTETSIIS CCCCCCCCCCHHHHC	39.89	29550500
780	Phosphorylation	DTKKGKSTETSIISK CCCCCCCCCHHHHCH	46.93	29550500
782	Phosphorylation	KKGKSTETSIISKKK CCCCCCCHHHHCHHH	25.89	29550500
783	Phosphorylation	KGKSTETSIISKKKR CCCCCCHHHHCHHHH	16.22	22006019
793	Phosphorylation	SKKKRQNYSESSNYD CHHHHCCCCCCCCCC	12.89	25619855
794	Phosphorylation	KKKRQNYSESSNYDS HHHHCCCCCCCCCCH	38.25	22942356
796	Phosphorylation	KRQNYSESSNYDSEL HHCCCCCCCCCCHHH	20.24	22324799
797	Phosphorylation	RQNYSESSNYDSELE HCCCCCCCCCCHHHH	35.04	27742792
799	Phosphorylation	NYSESSNYDSELERE CCCCCCCCCHHHHHH	23.85	25619855
801	Phosphorylation	SESSNYDSELEREIK CCCCCCCHHHHHHHH	33.45	27087446
819	Phosphorylation	RIGAARKSVPEKKEE HHHHHHHCCCCCCCC	37.03	29514104
828	Phosphorylation	PEKKEEDSSEDEKQG CCCCCCCCCCHHHHC	38.62	27087446
829	Phosphorylation	EKKEEDSSEDEKQGK CCCCCCCCCHHHHCC	62.48	27087446
849	Phosphorylation	GGHERAKTTQEGSSA CCCCCCCCCCCCCCC	32.50	25159016
850	Phosphorylation	GHERAKTTQEGSSAD CCCCCCCCCCCCCCC	24.74	23684622
854	Phosphorylation	AKTTQEGSSADDTGD CCCCCCCCCCCCCCC	22.92	25521595
855	Phosphorylation	KTTQEGSSADDTGDT CCCCCCCCCCCCCCC	46.72	25521595
859	Phosphorylation	EGSSADDTGDTEGRQ CCCCCCCCCCCCCCC	37.19	25159016
862	Phosphorylation	SADDTGDTEGRQGGS CCCCCCCCCCCCCCE	41.50	22324799
869	Phosphorylation	TEGRQGGSCSIAGGS CCCCCCCEEEECCCC	16.12	22817900
871	Phosphorylation	GRQGGSCSIAGGSIE CCCCCEEEECCCCHH	19.71	21183079
876	Phosphorylation	SCSIAGGSIEKVRSG EEEECCCCHHHHHCC	27.02	25266776
882	Phosphorylation	GSIEKVRSGVEFREM CCHHHHHCCCCHHHH	50.61	29176673
896	Phosphorylation	MLCKPGVSSDGAEKP HHCCCCCCCCCCCCC	28.73	22324799
897	Phosphorylation	LCKPGVSSDGAEKPS HCCCCCCCCCCCCCC	37.34	26824392
904	Phosphorylation	SDGAEKPSVKEENVN CCCCCCCCCCCCCCC	57.81	25159016
912	Phosphorylation	VKEENVNSPEDKRVS CCCCCCCCHHHHHCH	25.94	25521595
940	Phosphorylation	SRKGKGGSSDGTDRF CCCCCCCCCCCCCCC	33.65	26824392
941	Phosphorylation	RKGKGGSSDGTDRFP CCCCCCCCCCCCCCC	43.25	26824392
944	Phosphorylation	KGGSSDGTDRFPKKE CCCCCCCCCCCCCHH	29.05	28066266
953	Phosphorylation	RFPKKEQSDESSEGE CCCCHHHCCCCCHHH	44.42	27087446
956	Phosphorylation	KKEQSDESSEGEKKQ CHHHCCCCCHHHHHH	38.38	27087446
957	Phosphorylation	KEQSDESSEGEKKQS HHHCCCCCHHHHHHH	47.80	27087446
991	Phosphorylation	KREQEWDSSSDGTER CCHHCCCCCCCCCCC	32.58	27087446
992	Phosphorylation	REQEWDSSSDGTERL CHHCCCCCCCCCCCC	29.94	27087446
993	Phosphorylation	EQEWDSSSDGTERLP HHCCCCCCCCCCCCC	43.97	27087446
996	Phosphorylation	WDSSSDGTERLPEEE CCCCCCCCCCCCCHH	23.95	27087446
1009	Phosphorylation	EEEIGPFSKGIKQSK HHHCCCCCCCCCCCC	32.86	22324799
1041	Phosphorylation	CEKKEELSDSVDKLP CCCHHHHHHHHHCCC	30.99	27087446
1043	Phosphorylation	KKEELSDSVDKLPGK CHHHHHHHHHCCCCC	28.92	26824392
1053	Phosphorylation	KLPGKGDSCDSSEDK CCCCCCCCCCCCCCH	28.61	27087446
1056	Phosphorylation	GKGDSCDSSEDKKTR CCCCCCCCCCCHHHC	39.70	30352176
1057	Phosphorylation	KGDSCDSSEDKKTRN CCCCCCCCCCHHHCC	36.24	29472430
1063	Citrullination	SSEDKKTRNRVSLRE CCCCHHHCCCCHHHH	37.53	-
1063	Citrullination	SSEDKKTRNRVSLRE CCCCHHHCCCCHHHH	37.53	24463520
1067	Phosphorylation	KKTRNRVSLREKKRF HHHCCCCHHHHHHHH	20.62	29514104
1075	Phosphorylation	LREKKRFSLPAKSPG HHHHHHHCCCCCCCC	37.16	26824392
1080	Phosphorylation	RFSLPAKSPGKRPEC HHCCCCCCCCCCCCC	40.78	25159016
1088	Phosphorylation	PGKRPECSSSDTEKS CCCCCCCCCCCCCHH	31.08	27087446
1089	Phosphorylation	GKRPECSSSDTEKSL CCCCCCCCCCCCHHH	43.84	27087446
1090	Phosphorylation	KRPECSSSDTEKSLK CCCCCCCCCCCHHHC	32.05	27087446
1092	Phosphorylation	PECSSSDTEKSLKGQ CCCCCCCCCHHHCCC	47.46	22324799
1095	Phosphorylation	SSSDTEKSLKGQCCD CCCCCCHHHCCCCCC	29.13	25159016
1103	Phosphorylation	LKGQCCDSTEKRPKR HCCCCCCCCCCCCCC	25.26	25159016
1104	Phosphorylation	KGQCCDSTEKRPKRI CCCCCCCCCCCCCCC	32.07	25159016
1119	Phosphorylation	DLRERRNSSSKRNTK CHHHHHCCCCCCCHH	33.89	-
1120	Phosphorylation	LRERRNSSSKRNTKE HHHHHCCCCCCCHHH	43.35	22817900
1130	Phosphorylation	RNTKEVKSASSSSDA CCHHHHHHHCCCCCC	38.26	30635358
1132	Phosphorylation	TKEVKSASSSSDAEG HHHHHHHCCCCCCCC	37.53	29895711
1133	Phosphorylation	KEVKSASSSSDAEGS HHHHHHCCCCCCCCC	33.31	29895711
1134	Phosphorylation	EVKSASSSSDAEGSS HHHHHCCCCCCCCCC	29.73	29895711
1135	Phosphorylation	VKSASSSSDAEGSSE HHHHCCCCCCCCCCC	42.67	29895711
1140	Phosphorylation	SSSDAEGSSEDNKKQ CCCCCCCCCCHHHHH	23.27	23375375
1141	Phosphorylation	SSDAEGSSEDNKKQK CCCCCCCCCHHHHHH	60.88	27149854
1172	Phosphorylation	KRNSLRATPKRKQVD HHHCCCCCCCCCCCC	23.94	27681418
1182	Phosphorylation	RKQVDITSSSSDIGD CCCCCCCCCCCCCCC	28.67	29550500
1183	Phosphorylation	KQVDITSSSSDIGDD CCCCCCCCCCCCCCC	25.80	23375375
1184	Phosphorylation	QVDITSSSSDIGDDD CCCCCCCCCCCCCCC	31.62	29550500
1185	Phosphorylation	VDITSSSSDIGDDDQ CCCCCCCCCCCCCCC	34.88	23375375
1194	Phosphorylation	IGDDDQNSAGEESSD CCCCCCCCCCCCCCC	31.83	25195567
1199	Phosphorylation	QNSAGEESSDEQKIK CCCCCCCCCCHHHCC	38.49	23375375
1200	Phosphorylation	NSAGEESSDEQKIKP CCCCCCCCCHHHCCC	48.74	29550500
1209	Phosphorylation	EQKIKPVTENLVLPS HHHCCCCCCCCCCCC	27.90	24068923
1216	Phosphorylation	TENLVLPSHTGFCQS CCCCCCCCCCCCCCC	29.53	24925903
1218	Phosphorylation	NLVLPSHTGFCQSSG CCCCCCCCCCCCCCC	35.97	24925903
1223	Phosphorylation	SHTGFCQSSGDEALS CCCCCCCCCCCHHHH	37.15	25521595
1224	Phosphorylation	HTGFCQSSGDEALSK CCCCCCCCCCHHHHC	25.12	25521595
1230	Phosphorylation	SSGDEALSKSVPATV CCCCHHHHCCCCCCC	29.90	24925903
1232	Phosphorylation	GDEALSKSVPATVDD CCHHHHCCCCCCCCC	29.92	21149613
1236	Phosphorylation	LSKSVPATVDDDDDD HHCCCCCCCCCCCCC	20.56	21149613
1264	Phosphorylation	EEIKANLSSDEDGSS HHHHHHCCCCCCCCC	35.23	27149854
1265	Phosphorylation	EIKANLSSDEDGSSD HHHHHCCCCCCCCCC	48.46	27149854
1270	Phosphorylation	LSSDEDGSSDDEPDG CCCCCCCCCCCCCCC	42.80	27149854
1271	Phosphorylation	SSDEDGSSDDEPDGG CCCCCCCCCCCCCCC	55.39	27149854
1287	Phosphorylation	KKRIGKQSEESPADD CCCCCCCCCCCCCCC	46.98	26824392
1290	Phosphorylation	IGKQSEESPADDGEL CCCCCCCCCCCCCHH	22.72	27087446
1309	Phosphorylation	LAVNQVNSESDSDSE HHHHCCCCCCCCCCH	39.35	27149854
1311	Phosphorylation	VNQVNSESDSDSEES HHCCCCCCCCCCHHH	42.08	27149854
1313	Phosphorylation	QVNSESDSDSEESKK CCCCCCCCCCHHHCC	52.92	27149854
1315	Phosphorylation	NSESDSDSEESKKPR CCCCCCCCHHHCCHH	47.41	22324799
1318	Phosphorylation	SDSDSEESKKPRYRH CCCCCHHHCCHHHHH	41.76	22324799
1333	Phosphorylation	RLLRHKLTLSDGESG HHHHHCCCCCCCCCC	29.08	24925903
1335	Phosphorylation	LRHKLTLSDGESGEE HHHCCCCCCCCCCCC	38.03	24925903
1339	Phosphorylation	LTLSDGESGEEKPTK CCCCCCCCCCCCCCC	57.97	24925903
1345	Phosphorylation	ESGEEKPTKPKEHKE CCCCCCCCCCHHHHH	71.67	24925903
1405	Phosphorylation	ELEENQRSYKQKKKR HHHHHHHHHHHHHHH	27.24	29176673
1421	Phosphorylation	RIKVQEDSSSENKSH CCCCCCCCCCCCCCC	34.70	23684622
1422	Phosphorylation	IKVQEDSSSENKSHS CCCCCCCCCCCCCCC	54.73	23684622
1423	Phosphorylation	KVQEDSSSENKSHSE CCCCCCCCCCCCCCH	49.49	23684622
1427	Phosphorylation	DSSSENKSHSEEDKK CCCCCCCCCCHHHHC	43.77	23684622
1429	Phosphorylation	SSENKSHSEEDKKEG CCCCCCCCHHHHCCC	50.18	23684622
1455	Phosphorylation	EEDENDDSKSPGKGR CCCCCCCCCCCCCHH	37.59	21149613
1457	Phosphorylation	DENDDSKSPGKGRKK CCCCCCCCCCCHHHH	42.72	21149613
1512	Phosphorylation	VIEIEDASPTKCPIT HEECCCCCCCCCCCE	45.48	25521595
1514	Phosphorylation	EIEDASPTKCPITTK ECCCCCCCCCCCEEE	42.66	27087446
1519	Phosphorylation	SPTKCPITTKLVLDE CCCCCCCEEEEEECC	11.74	24068923
1520	Phosphorylation	PTKCPITTKLVLDEN CCCCCCEEEEEECCC	24.09	24068923
1830	Ubiquitination	RMTAIQCKLYQYYLD HHHHHHHHHHHHHHH	33.58	-
1878	Phosphorylation	PWCLQLDYISKENKG HHHHHHHHHCCCCCC	18.71	-
1881	Ubiquitination	LQLDYISKENKGYFD HHHHHHCCCCCCCCC	56.60	-
1891	Phosphorylation	KGYFDEDSMDEFIAS CCCCCCCCHHHHHHC	26.53	22817900
1898	Phosphorylation	SMDEFIASDSDETSK CHHHHHHCCCHHHHH	32.60	22817900
1900	Phosphorylation	DEFIASDSDETSKSL HHHHHCCCHHHHHCC	34.55	23375375
1903	Phosphorylation	IASDSDETSKSLSSD HHCCCHHHHHCCCCC	46.58	22817900
1906	Phosphorylation	DSDETSKSLSSDEKK CCHHHHHCCCCCCCC	33.00	26745281
1908	Phosphorylation	DETSKSLSSDEKKKP HHHHHCCCCCCCCCC	42.72	25195567
1909	Phosphorylation	ETSKSLSSDEKKKPK HHHHCCCCCCCCCCC	55.90	25195567
1924	Phosphorylation	GKKGKKDSSSSGSGS CCCCCCCCCCCCCCC	40.79	29550500
1925	Phosphorylation	KKGKKDSSSSGSGSD CCCCCCCCCCCCCCC	38.36	23375375
1926	Phosphorylation	KGKKDSSSSGSGSDN CCCCCCCCCCCCCCC	42.54	23375375
1927	Phosphorylation	GKKDSSSSGSGSDND CCCCCCCCCCCCCCC	38.64	23375375
1929	Phosphorylation	KDSSSSGSGSDNDVE CCCCCCCCCCCCCCE	36.75	25521595
1931	Phosphorylation	SSSSGSGSDNDVEVI CCCCCCCCCCCCEEE	34.63	25521595
1969	Phosphorylation	VSLKLDESKTTSTSN EEEEECCCCCCCCCC	34.66	25266776
1971	Phosphorylation	LKLDESKTTSTSNPS EEECCCCCCCCCCCC	34.95	27087446
1972	Phosphorylation	KLDESKTTSTSNPSS EECCCCCCCCCCCCC	33.47	23684622
1973	Phosphorylation	LDESKTTSTSNPSSP ECCCCCCCCCCCCCC	34.76	27742792
1974	Phosphorylation	DESKTTSTSNPSSPA CCCCCCCCCCCCCCC	30.36	22942356
1975	Phosphorylation	ESKTTSTSNPSSPAP CCCCCCCCCCCCCCC	46.65	27087446
1978	Phosphorylation	TTSTSNPSSPAPDWY CCCCCCCCCCCCHHH	53.88	27087446
1979	Phosphorylation	TSTSNPSSPAPDWYK CCCCCCCCCCCHHHH	26.74	27087446
1985	Phosphorylation	SSPAPDWYKDFVTDT CCCCCHHHHHCCCCC	14.20	25168779
1990	Phosphorylation	DWYKDFVTDTDAEVL HHHHHCCCCCCHHHH	32.92	25159016
1992	Phosphorylation	YKDFVTDTDAEVLEH HHHCCCCCCHHHHHH	27.95	25159016
2000	Phosphorylation	DAEVLEHSGKMVLLF CHHHHHHCCHHHHHH	30.63	25777480
2140	Phosphorylation	RVYRFGQTKPVYVYR EEEECCCCCCEEEEE	37.38	25890499
2175	Ubiquitination	LSFRVVDQQQVERHF EEEEECCHHHHHHHC	24.81	27667366
2191	Ubiquitination	MNELTELYTFEPDLL HHHCHHHHCCCHHHC	11.80	27667366
2203	Phosphorylation	DLLDDPNSEKKKKRD HHCCCCCCHHHCCCC	57.06	-
2211	Phosphorylation	EKKKKRDTPMLPKDT HHHCCCCCCCCCHHH	18.03	-
2213	Ubiquitination	KKKRDTPMLPKDTIL HCCCCCCCCCHHHHH	12.43	27667366
2229	Ubiquitination	ELLQIHKEHIVGYHE HHHHHHHHHHCCCCC	25.37	27667366
2244	Ubiquitination	HDSLLDHKEEEELTE CCCCCCHHHHHHCCH	67.50	27667366
2245	Ubiquitination	DSLLDHKEEEELTEE CCCCCHHHHHHCCHH	68.19	27667366
2265	Ubiquitination	WAEYEAEKKGLTMRF HHHHHHHHCCCEEEE	60.22	27667366
2268	Ubiquitination	YEAEKKGLTMRFNIP HHHHHCCCEEEEECC	4.70	27667366
2276	Phosphorylation	TMRFNIPTGTNLPPV EEEEECCCCCCCCCE	53.49	22802335
2278	Phosphorylation	RFNIPTGTNLPPVTF EEECCCCCCCCCEEE	35.74	22802335
2280	Ubiquitination	NIPTGTNLPPVTFTS ECCCCCCCCCEEECC	5.21	27667366
2282	Ubiquitination	PTGTNLPPVTFTSQT CCCCCCCCEEECCCC	40.73	27667366
2283	Ubiquitination	TGTNLPPVTFTSQTP CCCCCCCEEECCCCC	6.93	27667366
2284	Phosphorylation	GTNLPPVTFTSQTPY CCCCCCEEECCCCCC	27.28	22802335
2286	Phosphorylation	NLPPVTFTSQTPYIP CCCCEEECCCCCCCC	15.57	22802335
2300	Phosphorylation	PFNLGALSAMSNQQL CCCHHHHHHHCHHHH	22.76	22802335
2303	Phosphorylation	LGALSAMSNQQLEDL HHHHHHHCHHHHHHH	31.07	22802335
2362	Phosphorylation	LALSRQASQELDVKR HHHHHHHHHHHCHHH	18.82	25521595
2457	Methylation	MQPPPLQRAPPPTVR CCCCCCCCCCCCCCC	57.66	24129315
2464	Methylation	RAPPPTVRSKNPGPS CCCCCCCCCCCCCCC	44.37	24129315
2471	Phosphorylation	RSKNPGPSPGKSM-- CCCCCCCCCCCCC--	52.80	25263469

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ATRX_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ATRX_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ATRX_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MECP2_MOUSE	Mecp2	physical	17296936
SMC1A_MOUSE	Smc1a	physical	20159591
SMC3_MOUSE	Smc3	physical	20159591
MECP2_MOUSE	Mecp2	physical	20159591
ANDR_MOUSE	Ar	physical	21427128
PARP1_HUMAN	PARP1	physical	26496610
CHD1_HUMAN	CHD1	physical	26496610
DAXX_HUMAN	DAXX	physical	26496610
ORC1_HUMAN	ORC1	physical	26496610
PWP2_HUMAN	PWP2	physical	26496610
ELOC_HUMAN	TCEB1	physical	26496610
TOP2A_HUMAN	TOP2A	physical	26496610
TOP2B_HUMAN	TOP2B	physical	26496610
UBF1_HUMAN	UBTF	physical	26496610
H2B2E_HUMAN	HIST2H2BE	physical	26496610
CBX4_HUMAN	CBX4	physical	26496610
JADE3_HUMAN	JADE3	physical	26496610
RBX1_HUMAN	RBX1	physical	26496610
NS1BP_HUMAN	IVNS1ABP	physical	26496610
KAT7_HUMAN	KAT7	physical	26496610
SP16H_HUMAN	SUPT16H	physical	26496610
BRWD1_HUMAN	BRWD1	physical	26496610
PHIP_HUMAN	PHIP	physical	26496610
WDR76_HUMAN	WDR76	physical	26496610
ING5_HUMAN	ING5	physical	26496610
DPY30_HUMAN	DPY30	physical	26496610
EZH2_MOUSE	Ezh2	physical	25417162

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ATRX_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92, AND MASSSPECTROMETRY.	19131326 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92; SER-717; SER-719;SER-1041; SER-1290; SER-1335 AND SER-1339, AND MASS SPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-588; SER-626; SER-1339AND SER-1512, AND MASS SPECTROMETRY.	17242355 [Abstract]
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92, AND MASSSPECTROMETRY.	17203969 [Abstract]
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92, AND MASSSPECTROMETRY.	16452087 [Abstract]