dbPTM

JADE3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	JADE3_HUMAN
UniProt AC	Q92613
Protein Name	Protein Jade-3
Gene Name	JADE3
Organism	Homo sapiens (Human).
Sequence Length	823
Subcellular Localization
Protein Description	Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo..
Protein Sequence	MKRHRPVSSSDSSDESPSTSFTSGSMYRIKSKIPNEHKKPAEVFRKDLISAMKLPDSHHINPDSYYLFADTWKEEWEKGVQVPASPDTVPQPSLRIIAEKVKDVLFIRPRKYIHCSSPDTTEPGYINIMELAASVCRYDLDDMDIFWLQELNEDLAEMGCGPVDENLMEKTVEVLERHCHENMNHAIETEEGLGIEYDEDVICDVCRSPDSEEGNDMVFCDKCNVCVHQACYGILKVPEGSWLCRSCVLGIYPQCVLCPKKGGALKTTKTGTKWAHVSCALWIPEVSIACPERMEPITKISHIPPSRWALVCNLCKLKTGACIQCSIKSCITAFHVTCAFEHGLEMKTILDEGDEVKFKSYCLKHSQNRQKLGEAEYPHHRAKEQSQAKSEKTSLRAQKLRELEEEFYSLVRVEDVAAELGMPTLAVDFIYNYWKLKRKSNFNKPLFPPKEDEENGLVQPKEESIHTRMRMFMHLRQDLERVRNLCYMISRREKLKLSHNKIQEQIFGLQVQLLNQEIDAGLPLTNALENSLFYPPPRITLKLKMPKSTPEDHRNSSTETDQQPHSPDSSSSVHSIRNMQVPQESLEMRTKSYPRYPLESKNNRLLASLSHSRSEAKESSPAWRTPSSECYHGQSLGKPLVLQAALHGQSSIGNGKSQPNSKFAKSNGLEGSWSGNVTQKDSSSEMFCDQEPVFSPHLVSQGSFRKSTVEHFSRSFKETTNRWVKNTEDLQCYVKPTKNMSPKEQFWGRQVLRRSAGRAPYQENDGYCPDLELSDSEAESDGNKEKVRVRKDSSDRENPPHDSRRDCHGKSKTHPLSHSSMQR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MKRHRPVSSSDSSDE CCCCCCCCCCCCCCC	27.14	20873877
9	Phosphorylation	KRHRPVSSSDSSDES CCCCCCCCCCCCCCC	38.10	20873877
10	Phosphorylation	RHRPVSSSDSSDESP CCCCCCCCCCCCCCC	33.72	20873877
12	Phosphorylation	RPVSSSDSSDESPST CCCCCCCCCCCCCCC	41.45	20873877
13	Phosphorylation	PVSSSDSSDESPSTS CCCCCCCCCCCCCCC	50.84	30576142
16	Phosphorylation	SSDSSDESPSTSFTS CCCCCCCCCCCCCCC	29.19	20873877
18	Phosphorylation	DSSDESPSTSFTSGS CCCCCCCCCCCCCCC	46.06	20873877
19	Phosphorylation	SSDESPSTSFTSGSM CCCCCCCCCCCCCCC	31.11	20873877
20	Phosphorylation	SDESPSTSFTSGSMY CCCCCCCCCCCCCCE	30.75	20873877
22	Phosphorylation	ESPSTSFTSGSMYRI CCCCCCCCCCCCEEE	31.76	23312004
23	Phosphorylation	SPSTSFTSGSMYRIK CCCCCCCCCCCEEEC	27.19	27251275
25	Phosphorylation	STSFTSGSMYRIKSK CCCCCCCCCEEECCC	16.65	27251275
27	Phosphorylation	SFTSGSMYRIKSKIP CCCCCCCEEECCCCC	15.75	22817900
30	Acetylation	SGSMYRIKSKIPNEH CCCCEEECCCCCCCC	36.38	19608861
32	Acetylation	SMYRIKSKIPNEHKK CCEEECCCCCCCCCC	58.12	19608861
38	Acetylation	SKIPNEHKKPAEVFR CCCCCCCCCCHHHHH	55.03	23749302
39	Acetylation	KIPNEHKKPAEVFRK CCCCCCCCCHHHHHH	51.90	26051181
46	Ubiquitination	KPAEVFRKDLISAMK CCHHHHHHHHHHHCC	45.48	-
78	Ubiquitination	TWKEEWEKGVQVPAS CHHHHHHHCCCCCCC	66.51	-
85	Phosphorylation	KGVQVPASPDTVPQP HCCCCCCCCCCCCCC	19.76	23401153
88	Phosphorylation	QVPASPDTVPQPSLR CCCCCCCCCCCCCHH	37.15	30266825
93	Phosphorylation	PDTVPQPSLRIIAEK CCCCCCCCHHHHHHH	25.65	24732914
112	Phosphorylation	LFIRPRKYIHCSSPD EEECCCCEEECCCCC	9.36	27080861
116	Phosphorylation	PRKYIHCSSPDTTEP CCCEEECCCCCCCCC	30.64	26074081
117	Phosphorylation	RKYIHCSSPDTTEPG CCEEECCCCCCCCCC	31.99	26074081
120	Phosphorylation	IHCSSPDTTEPGYIN EECCCCCCCCCCCCC	36.12	26074081
121	Phosphorylation	HCSSPDTTEPGYINI ECCCCCCCCCCCCCH	47.78	26074081
125	Phosphorylation	PDTTEPGYINIMELA CCCCCCCCCCHHHHH	11.08	27080861
208	Phosphorylation	VICDVCRSPDSEEGN CEEEECCCCCCCCCC	28.12	20873877
211	Phosphorylation	DVCRSPDSEEGNDMV EECCCCCCCCCCCCE	40.71	20873877
273	Acetylation	KTTKTGTKWAHVSCA EECCCCCCEEEEEEE	43.67	25953088
299	Acetylation	ERMEPITKISHIPPS CCCCCCCEECCCCHH	42.82	23236377
316	Acetylation	ALVCNLCKLKTGACI HHHHHHHCCCCCCEE	57.07	25953088
318	Ubiquitination	VCNLCKLKTGACIQC HHHHHCCCCCCEEEC	30.33	-
348	Phosphorylation	EHGLEMKTILDEGDE HCCCEEEEECCCCCC	26.01	-
357	Ubiquitination	LDEGDEVKFKSYCLK CCCCCCEEHHHHHHH	45.05	-
364	Acetylation	KFKSYCLKHSQNRQK EHHHHHHHHCHHHHH	37.33	25953088
364	Ubiquitination	KFKSYCLKHSQNRQK EHHHHHHHHCHHHHH	37.33	-
371	Acetylation	KHSQNRQKLGEAEYP HHCHHHHHHCCCCCH	56.04	23749302
371	Ubiquitination	KHSQNRQKLGEAEYP HHCHHHHHHCCCCCH	56.04	-
377	Phosphorylation	QKLGEAEYPHHRAKE HHHCCCCCHHHHHHH	18.21	25404012
383	Acetylation	EYPHHRAKEQSQAKS CCHHHHHHHHHHHHH	57.13	23236377
386	Phosphorylation	HHRAKEQSQAKSEKT HHHHHHHHHHHHHHH	32.95	25404012
389	Acetylation	AKEQSQAKSEKTSLR HHHHHHHHHHHHHHH	52.06	23236377
408	Phosphorylation	RELEEEFYSLVRVED HHHHHHHHHHCCHHH	12.36	27642862
433	Phosphorylation	AVDFIYNYWKLKRKS HHHHHHHHHHHHCCC	6.22	20058876
440	Phosphorylation	YWKLKRKSNFNKPLF HHHHHCCCCCCCCCC	51.16	-
461	Acetylation	ENGLVQPKEESIHTR CCCCCCCCHHHHHHH	57.95	23954790
464	Phosphorylation	LVQPKEESIHTRMRM CCCCCHHHHHHHHHH	22.29	27251275
467	Phosphorylation	PKEESIHTRMRMFMH CCHHHHHHHHHHHHH	25.21	27251275
496	Ubiquitination	ISRREKLKLSHNKIQ HHHHHHHCCCCHHHH	60.04	-
548	Phosphorylation	LKLKMPKSTPEDHRN EEEECCCCCCCCCCC	43.24	21955146
549	Phosphorylation	KLKMPKSTPEDHRNS EEECCCCCCCCCCCC	36.50	21955146
556	Phosphorylation	TPEDHRNSSTETDQQ CCCCCCCCCCCCCCC	38.30	29255136
557	Phosphorylation	PEDHRNSSTETDQQP CCCCCCCCCCCCCCC	33.54	29255136
558	Phosphorylation	EDHRNSSTETDQQPH CCCCCCCCCCCCCCC	42.60	29255136
560	Phosphorylation	HRNSSTETDQQPHSP CCCCCCCCCCCCCCC	38.91	29255136
566	Phosphorylation	ETDQQPHSPDSSSSV CCCCCCCCCCCCCCH	36.77	29255136
569	Phosphorylation	QQPHSPDSSSSVHSI CCCCCCCCCCCHHHH	35.19	29255136
570	Phosphorylation	QPHSPDSSSSVHSIR CCCCCCCCCCHHHHH	33.73	29255136
571	Phosphorylation	PHSPDSSSSVHSIRN CCCCCCCCCHHHHHC	40.09	29255136
572	Phosphorylation	HSPDSSSSVHSIRNM CCCCCCCCHHHHHCC	26.29	29255136
575	Phosphorylation	DSSSSVHSIRNMQVP CCCCCHHHHHCCCCC	22.53	22167270
585	Phosphorylation	NMQVPQESLEMRTKS CCCCCHHHHHHHCCC	25.12	21815630
592	Phosphorylation	SLEMRTKSYPRYPLE HHHHHCCCCCCCCCC	39.49	25159151
601	Acetylation	PRYPLESKNNRLLAS CCCCCCCCCCHHHHH	49.19	25953088
608	Phosphorylation	KNNRLLASLSHSRSE CCCHHHHHHHCCHHH	30.30	20068231
610	Phosphorylation	NRLLASLSHSRSEAK CHHHHHHHCCHHHHH	19.54	20068231
612	Phosphorylation	LLASLSHSRSEAKES HHHHHHCCHHHHHCC	33.84	29116813
613	Methylation	LASLSHSRSEAKESS HHHHHCCHHHHHCCC	32.85	115480711
614	Phosphorylation	ASLSHSRSEAKESSP HHHHCCHHHHHCCCC	44.94	29759185
617	Acetylation	SHSRSEAKESSPAWR HCCHHHHHCCCCCCC	54.82	26051181
620	Phosphorylation	RSEAKESSPAWRTPS HHHHHCCCCCCCCCC	21.52	21815630
625	Phosphorylation	ESSPAWRTPSSECYH CCCCCCCCCCCCCCC	19.47	25159151
627	Phosphorylation	SPAWRTPSSECYHGQ CCCCCCCCCCCCCCC	37.85	26074081
628	Phosphorylation	PAWRTPSSECYHGQS CCCCCCCCCCCCCCC	32.65	26074081
631	Phosphorylation	RTPSSECYHGQSLGK CCCCCCCCCCCCCCC	12.63	26074081
635	Phosphorylation	SECYHGQSLGKPLVL CCCCCCCCCCCCHHH	43.62	25159151
638	Acetylation	YHGQSLGKPLVLQAA CCCCCCCCCHHHHHH	40.23	19608861
650	Phosphorylation	QAALHGQSSIGNGKS HHHHCCCCCCCCCCC	28.63	26074081
651	Phosphorylation	AALHGQSSIGNGKSQ HHHCCCCCCCCCCCC	26.99	26074081
656	Acetylation	QSSIGNGKSQPNSKF CCCCCCCCCCCCCCC	50.33	23749302
662	Acetylation	GKSQPNSKFAKSNGL CCCCCCCCCCHHCCC	56.85	25953088
665	Acetylation	QPNSKFAKSNGLEGS CCCCCCCHHCCCCCC	47.81	25953088
672	Phosphorylation	KSNGLEGSWSGNVTQ HHCCCCCCCCCCCCC	14.53	25159151
674	Phosphorylation	NGLEGSWSGNVTQKD CCCCCCCCCCCCCCC	23.37	25627689
695	Phosphorylation	CDQEPVFSPHLVSQG ECCCCCCCHHHHCCC	16.19	24732914
700	Phosphorylation	VFSPHLVSQGSFRKS CCCHHHHCCCCCCHH	34.87	24732914
703	Phosphorylation	PHLVSQGSFRKSTVE HHHHCCCCCCHHHHH	17.78	24732914
706	Ubiquitination	VSQGSFRKSTVEHFS HCCCCCCHHHHHHHH	48.76	-
707	Phosphorylation	SQGSFRKSTVEHFSR CCCCCCHHHHHHHHH	33.17	25159151
708	Phosphorylation	QGSFRKSTVEHFSRS CCCCCHHHHHHHHHH	32.71	26074081
715	Phosphorylation	TVEHFSRSFKETTNR HHHHHHHHHHHHHHH	39.20	-
725	Ubiquitination	ETTNRWVKNTEDLQC HHHHHHHCCCCCCEE	51.71	-
733	Phosphorylation	NTEDLQCYVKPTKNM CCCCCEEEECCCCCC	9.88	27642862
735	Acetylation	EDLQCYVKPTKNMSP CCCEEEECCCCCCCH	22.09	23749302
735	Ubiquitination	EDLQCYVKPTKNMSP CCCEEEECCCCCCCH	22.09	19608861
738	Acetylation	QCYVKPTKNMSPKEQ EEEECCCCCCCHHHH	60.21	25953088
741	Phosphorylation	VKPTKNMSPKEQFWG ECCCCCCCHHHHHHH	42.06	26074081
743	Acetylation	PTKNMSPKEQFWGRQ CCCCCCHHHHHHHHH	57.76	26051181
755	Phosphorylation	GRQVLRRSAGRAPYQ HHHHHHHHCCCCCCC	28.74	23312004
761	Phosphorylation	RSAGRAPYQENDGYC HHCCCCCCCCCCCCC	27.72	28450419
767	Phosphorylation	PYQENDGYCPDLELS CCCCCCCCCCCCCCC	12.04	23663014
774	Phosphorylation	YCPDLELSDSEAESD CCCCCCCCHHHHCCC	29.70	23401153
776	Phosphorylation	PDLELSDSEAESDGN CCCCCCHHHHCCCCC	35.02	30278072
780	Phosphorylation	LSDSEAESDGNKEKV CCHHHHCCCCCCCCE	58.84	22617229
793	Phosphorylation	KVRVRKDSSDRENPP CEEECCCCCCCCCCC	36.85	27273156
794	Phosphorylation	VRVRKDSSDRENPPH EEECCCCCCCCCCCC	51.31	23663014
803	Phosphorylation	RENPPHDSRRDCHGK CCCCCCCCCCCCCCC	26.61	23663014
812	Ubiquitination	RDCHGKSKTHPLSHS CCCCCCCCCCCCCHH	55.10	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of JADE3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of JADE3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of JADE3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of JADE3_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of JADE3_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-30; LYS-32; LYS-461 ANDLYS-638, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85; THR-560; SER-566;SER-774 AND SER-776, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-774; SER-776 ANDSER-780, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85 AND SER-566, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-566, AND MASSSPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85, AND MASSSPECTROMETRY.	15302935 [Abstract]