MSL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MSL1_MOUSE
• UniProt AC: Q6PDM1
• Protein Name: Male-specific lethal 1 homolog
• Gene Name: Msl1
• Organism: Mus musculus (Mouse).
• Sequence Length: 616
• Subcellular Localization: Nucleus .
• Protein Description: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-17' which is implicated in the formation of higher-order chromatin. structure (By similarity). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub). This modification in turn stimulates histone H3 methylation at 'Lys-5' (H3K4me) and 'Lys-80' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation..
• Protein Sequence: MTMRSAVFKAAAAPAGGNPEQRLDYERAAALGGPEDESGAAEAHFLPRHRKLKEPGPPLASSQGGSPSPSPAGCGGGKGRGLLLPAGAAPGQQEESWGGSVPLPCPPPATKQAGIGGEPVAAGAGCSPRPKYQAVLPIQTGSIVVAAAKEPTPWAGDKGGAAPPAATASDPAGPPPLPLPGPPPLAPTATAGTLAASEGRWKSIRKSPLGGGGGSGASSQAACLKQILLLQLDLIEQQQQQLQAKEKEIEELKSERDTLLARIERMERRMQLVKRDNEKERHKLLQGYEPEEREEAELSEKIKLERQPELCETSQALPSKPFSCGRSGKGHKRKTPFGNTERKTPVKKLAPEFSKVKTKTPKHSPIKEEPCGSISETVCKRELRSQETPEKPRSSVDTPPRLSTPQKGPSTHPKEKAFSSEMEDLPYLSTTEMYLCRWHQPPPSPLPLRESSPKKEETVARCLMPSSVAGETSVLAVPSWRDHSVEPLRDPNPSDILENLDDSVFSKRHAKLELDEKRRKRWDIQRIREQRILQRLQLRMYKKKGIQESEPEVTSFFPEPDDVESLLITPFLPVVAFGRPLPKLAPQNFELPWLDERSRCRLEIQKKHTPHRTCRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	Phosphorylation	EPGPPLASSQGGSPS CCCCCCCCCCCCCCC	30.77	25619855
62	Phosphorylation	PGPPLASSQGGSPSP CCCCCCCCCCCCCCC	27.51	25619855
66	Phosphorylation	LASSQGGSPSPSPAG CCCCCCCCCCCCCCC	29.09	25619855
68	Phosphorylation	SSQGGSPSPSPAGCG CCCCCCCCCCCCCCC	39.44	25619855
70	Phosphorylation	QGGSPSPSPAGCGGG CCCCCCCCCCCCCCC	31.55	25619855
127	Phosphorylation	VAAGAGCSPRPKYQA CCCCCCCCCCCCEEE	24.03	26824392
149	Acetylation	SIVVAAAKEPTPWAG CEEEEECCCCCCCCC	60.54	22826441
207	Phosphorylation	RWKSIRKSPLGGGGG CCCCCCCCCCCCCCC	18.60	25521595
215	Phosphorylation	PLGGGGGSGASSQAA CCCCCCCCCHHHHHH	34.17	25619855
355	Acetylation	KLAPEFSKVKTKTPK HHCCCHHCCCCCCCC	53.74	22902405
358	Phosphorylation	PEFSKVKTKTPKHSP CCHHCCCCCCCCCCC	43.04	24719451
360	Phosphorylation	FSKVKTKTPKHSPIK HHCCCCCCCCCCCCC	42.68	25266776
364	Phosphorylation	KTKTPKHSPIKEEPC CCCCCCCCCCCCCCC	34.15	25619855
385	Phosphorylation	VCKRELRSQETPEKP HHHHHHHCCCCCCCC	45.02	27149854
388	Phosphorylation	RELRSQETPEKPRSS HHHHCCCCCCCCCCC	29.16	25266776
394	Phosphorylation	ETPEKPRSSVDTPPR CCCCCCCCCCCCCCC	43.15	24719451
395	Phosphorylation	TPEKPRSSVDTPPRL CCCCCCCCCCCCCCC	25.87	25777480
398	Phosphorylation	KPRSSVDTPPRLSTP CCCCCCCCCCCCCCC	32.79	25266776
403	Phosphorylation	VDTPPRLSTPQKGPS CCCCCCCCCCCCCCC	39.04	24719451
404	Phosphorylation	DTPPRLSTPQKGPST CCCCCCCCCCCCCCC	34.04	25263469
410	Phosphorylation	STPQKGPSTHPKEKA CCCCCCCCCCCCHHH	48.28	25777480
411	Phosphorylation	TPQKGPSTHPKEKAF CCCCCCCCCCCHHHC	45.38	25777480
444	Phosphorylation	RWHQPPPSPLPLRES CCCCCCCCCCCCCCC	44.86	25159016
451	Phosphorylation	SPLPLRESSPKKEET CCCCCCCCCCCHHHH	45.57	30482847
452	Phosphorylation	PLPLRESSPKKEETV CCCCCCCCCCHHHHH	35.67	24719451
454	Acetylation	PLRESSPKKEETVAR CCCCCCCCHHHHHHH	74.82	22902405
511	Acetylation	VFSKRHAKLELDEKR HHHHHHHCCCCHHHH	36.05	22826441

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MSL1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MSL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MSL1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TTC4_MOUSE	Ttc4	physical	17335777
PIHD1_MOUSE	Pih1d1	physical	17335777
KAT8_MOUSE	Kat8	physical	17335777

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.