TBL1X_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBL1X_MOUSE
• UniProt AC: Q9QXE7
• Protein Name: F-box-like/WD repeat-containing protein TBL1X
• Gene Name: Tbl1x
• Organism: Mus musculus (Mouse).
• Sequence Length: 527
• Subcellular Localization: Nucleus. Colocalized with MECP2 to the heterochromatin foci.
• Protein Description: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity)..
• Protein Sequence: MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQANAAAAAAAAAATATSTAATTPAAAAQQNPPKNGEATVNGEENGAHAINNHSKPMEIDGDVEIPPSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNKKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDVERGVCIHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGSLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSITSDEVN ------CCCCHHHHH	34.28	-
102	Acetylation	RQQAFREKLAQQQAN HHHHHHHHHHHHHHH	44.88	-
122	Phosphorylation	AAAAATATSTAATTP HHHHHHHHHHHHCCH	23.43	26643407
123	Phosphorylation	AAAATATSTAATTPA HHHHHHHHHHHCCHH	17.37	26643407
124	Phosphorylation	AAATATSTAATTPAA HHHHHHHHHHCCHHH	18.89	26643407
127	Phosphorylation	TATSTAATTPAAAAQ HHHHHHHCCHHHHHH	30.74	26643407
128	Phosphorylation	ATSTAATTPAAAAQQ HHHHHHCCHHHHHHH	13.25	26643407
290	Ubiquitination	FALKWNKKGNYILSA EEEEECCCCCEEEEE	49.53	27667366
459	Phosphorylation	TKHQEPVYSVAFSPD CCCCCCEEEEEECCC	14.24	18563927

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBL1X_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBL1X_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBL1X_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BARX2_MOUSE	Barx2	physical	15728386

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.