TBL1R_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBL1R_MOUSE
• UniProt AC: Q8BHJ5
• Protein Name: F-box-like/WD repeat-containing protein TBL1XR1
• Gene Name: Tbl1xr1
• Organism: Mus musculus (Mouse).
• Sequence Length: 514
• Subcellular Localization: Nucleus.
• Protein Description: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation (By similarity)..
• Protein Sequence: MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGTLFDGRPIESLSLIDAVMPDVVQTRQQAYRDKLAQQHAAAAAAAAAATNQQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPSNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGPTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDLRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSISSDEVN ------CCCCHHHHH	31.04	-
2	Phosphorylation	------MSISSDEVN ------CCCCHHHHH	31.04	29895711
4	Phosphorylation	----MSISSDEVNFL ----CCCCHHHHHHH	25.16	29895711
5	Phosphorylation	---MSISSDEVNFLV ---CCCCHHHHHHHH	35.80	29895711
13	Phosphorylation	DEVNFLVYRYLQESG HHHHHHHHHHHHHCC	8.83	29895711
102	Acetylation	RQQAYRDKLAQQHAA HHHHHHHHHHHHHHH	36.40	23806337
102	Ubiquitination	RQQAYRDKLAQQHAA HHHHHHHHHHHHHHH	36.40	22790023
118	Phosphorylation	AAAAAAATNQQGSAK HHHHHHHHHCCCCCC	28.91	28285833
123	Phosphorylation	AATNQQGSAKNGENT HHHHCCCCCCCCCCC	31.56	29514104
277	Ubiquitination	FALKWNKKGNFILSA EEEEECCCCCEEEEE	56.74	22790023
446	Phosphorylation	TKHQEPVYSVAFSPD CCCCCCEEEEEECCC	14.24	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBL1R_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBL1R_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBL1R_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TBL1R_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.