| UniProt ID | PFKAP_MOUSE | |
|---|---|---|
| UniProt AC | Q9WUA3 | |
| Protein Name | ATP-dependent 6-phosphofructokinase, platelet type {ECO:0000255|HAMAP-Rule:MF_03184} | |
| Gene Name | Pfkp | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 784 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.. | |
| Protein Sequence | MSDLDSSSSSAYPKYLEHLSGDGKAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGGSNIVEAKWDCVSSILQVGGTIIGSARCKAFRSREGRLKAACNLARLGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGDIDNDTVQKYSYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDWEENMCLKLSENRARKKRLNIIIVSEGAIDMQNKPITSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPETPACVVSLRGNQAVRLPLMECVQMTQDVQKAMDERRFKEAVKLRGRRFEGNLNTYKRLAIKLPDEKIVKSNCNVAVINVGAPAAGMNAAVRSAVRVGIADGHKMFAIYDGFEGFANGQIKEIGWADVGGWTGQGGSILGTKRTLPGKYLEKIAEQMHSHSINALLIIGGFEAYLGLLELAAAREKHEAFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGALAAGADAAYIFEEPFDIGDLQSNVVHLTEKMKTSIQRGLVLRNESCSVNYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAMEWISAKLKGSQGTGKKFVSDDSICVLGICKRDLLFQPVAELKKVTDFEHRIPKEQWWLKLRPIMKILAKYEASYDMSDSGKLESLQHHEEL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MSDLDSSS -------CCCCCCCC | - | ||
| 2 | Phosphorylation | ------MSDLDSSSS ------CCCCCCCCC | 27742792 | ||
| 6 | Phosphorylation | --MSDLDSSSSSAYP --CCCCCCCCCCCCH | 25266776 | ||
| 7 | Phosphorylation | -MSDLDSSSSSAYPK -CCCCCCCCCCCCHH | 25266776 | ||
| 8 | Phosphorylation | MSDLDSSSSSAYPKY CCCCCCCCCCCCHHH | 29895711 | ||
| 9 | Phosphorylation | SDLDSSSSSAYPKYL CCCCCCCCCCCHHHH | 29895711 | ||
| 10 | Phosphorylation | DLDSSSSSAYPKYLE CCCCCCCCCCHHHHH | 29895711 | ||
| 12 | Phosphorylation | DSSSSSAYPKYLEHL CCCCCCCCHHHHHHH | 27742792 | ||
| 14 | Ubiquitination | SSSSAYPKYLEHLSG CCCCCCHHHHHHHCC | - | ||
| 20 | Phosphorylation | PKYLEHLSGDGKAIG HHHHHHHCCCCCEEE | - | ||
| 129 | Phosphorylation | CVIGGDGSLTGANLF EEECCCCCCCHHHHH | 26239621 | ||
| 131 | Phosphorylation | IGGDGSLTGANLFRK ECCCCCCCHHHHHHH | 26239621 | ||
| 138 | Ubiquitination | TGANLFRKEWSGLLE CHHHHHHHHHHHHHH | - | ||
| 141 | Phosphorylation | NLFRKEWSGLLEELA HHHHHHHHHHHHHHH | 22817900 | ||
| 286 | Ubiquitination | NKPITSEKIKELVVK CCCCCHHHHHHHHHH | - | ||
| 288 | Ubiquitination | PITSEKIKELVVKNL CCCHHHHHHHHHHHC | - | ||
| 293 | Ubiquitination | KIKELVVKNLGFDTR HHHHHHHHHCCCCCE | - | ||
| 312 | Phosphorylation | GHVQRGGTPSAFDRI EEHHHCCCCCHHHHH | 24899341 | ||
| 314 | Phosphorylation | VQRGGTPSAFDRILA HHHCCCCCHHHHHHH | 23737553 | ||
| 363 | Phosphorylation | LMECVQMTQDVQKAM HHHHHHHHHHHHHHH | 20531401 | ||
| 394 | Acetylation | EGNLNTYKRLAIKLP CCCCCHHHHEEEECC | - | ||
| 394 | Ubiquitination | EGNLNTYKRLAIKLP CCCCCHHHHEEEECC | - | ||
| 410 | S-nitrosocysteine | EKIVKSNCNVAVINV HHHHHCCCCEEEEEC | - | ||
| 481 | Phosphorylation | SILGTKRTLPGKYLE CCCCCCCCCCHHHHH | 30387612 | ||
| 485 | Acetylation | TKRTLPGKYLEKIAE CCCCCCHHHHHHHHH | - | ||
| 539 | O-linked_Glycosylation | VMVPATVSNNVPGSD EEEECEECCCCCCCC | - | ||
| 639 | Phosphorylation | GLVLRNESCSVNYTT CCEECCCCCCCEEEH | 22345495 | ||
| 640 | S-palmitoylation | LVLRNESCSVNYTTD CEECCCCCCCEEEHH | 28680068 | ||
| 641 | Phosphorylation | VLRNESCSVNYTTDF EECCCCCCCEEEHHH | 22345495 | ||
| 644 | Phosphorylation | NESCSVNYTTDFIYQ CCCCCCEEEHHHHHH | 22345495 | ||
| 645 | Phosphorylation | ESCSVNYTTDFIYQL CCCCCEEEHHHHHHH | 22345495 | ||
| 646 | Phosphorylation | SCSVNYTTDFIYQLY CCCCEEEHHHHHHHH | 22345495 | ||
| 650 | Phosphorylation | NYTTDFIYQLYSEEG EEEHHHHHHHHCCCC | 22817900 | ||
| 653 | Phosphorylation | TDFIYQLYSEEGKGV HHHHHHHHCCCCCCC | 22345495 | ||
| 654 | Phosphorylation | DFIYQLYSEEGKGVF HHHHHHHCCCCCCCE | 22345495 | ||
| 687 | Ubiquitination | FDRNFGTKISAKAME CCCCCCCCCHHHHHH | - | ||
| 687 | Acetylation | FDRNFGTKISAKAME CCCCCCCCCHHHHHH | 23806337 | ||
| 691 | Ubiquitination | FGTKISAKAMEWISA CCCCCHHHHHHHHHH | - | ||
| 712 | Phosphorylation | GTGKKFVSDDSICVL CCCCCCCCCCCEEEE | 22817900 | ||
| 767 | Phosphorylation | LAKYEASYDMSDSGK HHHHHHCCCCCCCCC | 22807455 | ||
| 770 | Phosphorylation | YEASYDMSDSGKLES HHHCCCCCCCCCCCC | 26643407 | ||
| 772 | Phosphorylation | ASYDMSDSGKLESLQ HCCCCCCCCCCCCCC | 26643407 | ||
| 774 | Ubiquitination | YDMSDSGKLESLQHH CCCCCCCCCCCCCCC | - | ||
| 777 | Phosphorylation | SDSGKLESLQHHEEL CCCCCCCCCCCCCCC | 22324799 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PFKAP_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PFKAP_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PFKAP_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PFKAP_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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