dbPTM

ARI3A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ARI3A_MOUSE
UniProt AC	Q62431
Protein Name	AT-rich interactive domain-containing protein 3A
Gene Name	Arid3a
Organism	Mus musculus (Mouse).
Sequence Length	601
Subcellular Localization	Nucleus. Cytoplasm. Shuttles between nucleus and cytoplasm.
Protein Description	Transcription factor involved in B-cell differentiation. Binds a VH promoter proximal site necessary for induced mu-heavy-chain transcription. Binds the minor groove of a restricted ATC sequence that is sufficient for nuclear matrix association. This sequence motif is present in matrix-associating regions (MARS) proximal to the promoter and flanking E mu. Activates E mu-driven transcription by binding these sites. May be involved in the control of cell cycle progression by the RB1/E2F1 pathway..
Protein Sequence	MKLQAVMETLIQRQQRARQELEARQAPPPPPPEPTGVRARTTMTDEDREPENARMHRTQMAALAAMRAAAAGLGHPSSPGGSEDGPPISGDEDTAREGTLSSPALHGSVLEGAGHAEGDRHLMDVGSDDDDTKSKWEEQELEELGEEEEEEEEEDDFEEEEEEEEGLGPPESASLGTAGLFTRKAPPAQAFRGDGGPRMLSGPERLGPGPAHPSHMASQMPPPDHGDWTFEEQFKQLYELDADPKRKEFLDDLFSFMQKRGTPVNRIPIMAKQVLDLFMLYVLVTEKGGLVEVINKKLWREITKGLNLPTSITSAAFTLRTQYMKYLYPYECERRGLSSPNELQAAIDSNRREGRRQSFGGSLFAYSPSGAHSMLPSPKLPVTPLGLAASTNGSSITPAPKIKKEEDSAIPITVPGRLPVSLAGHPVVAAQAAAVQAAAAQAAVAAQAAALEQLREKLESTEPPEKKMALVADEQQRLMQRAVQQSFLAMTAQLPMNIRINSQASESRQDSAVSLTSANGSNSISMSVEMNGIVYTGVLFAQPPPPTAPSAPGKGGVSSIGTNTTTGSRTGASGSTVSGGQVGLPGVSTPTMSSTSNNSLP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	PTGVRARTTMTDEDR CCCCCCCCCCCCCCC	21.67	24759943
42	Phosphorylation	TGVRARTTMTDEDRE CCCCCCCCCCCCCCC	16.72	24759943
44	Phosphorylation	VRARTTMTDEDREPE CCCCCCCCCCCCCHH	33.86	24759943
77	Phosphorylation	AAGLGHPSSPGGSED HHCCCCCCCCCCCCC	43.41	22942356
78	Phosphorylation	AGLGHPSSPGGSEDG HCCCCCCCCCCCCCC	31.83	22942356
82	Phosphorylation	HPSSPGGSEDGPPIS CCCCCCCCCCCCCCC	38.13	22942356
89	Phosphorylation	SEDGPPISGDEDTAR CCCCCCCCCCCCCCC	46.06	21082442
94	Phosphorylation	PISGDEDTAREGTLS CCCCCCCCCCCCCCC	26.10	25619855
99	Phosphorylation	EDTAREGTLSSPALH CCCCCCCCCCCHHHC	20.79	25159016
101	Phosphorylation	TAREGTLSSPALHGS CCCCCCCCCHHHCCH	33.83	28507225
102	Phosphorylation	AREGTLSSPALHGSV CCCCCCCCHHHCCHH	19.80	24704852
108	Phosphorylation	SSPALHGSVLEGAGH CCHHHCCHHHCCCCC	16.87	28066266
127	Phosphorylation	RHLMDVGSDDDDTKS CCEECCCCCCCCHHH	37.40	27742792
132	Phosphorylation	VGSDDDDTKSKWEEQ CCCCCCCHHHHHHHH	44.18	25619855
134	Phosphorylation	SDDDDTKSKWEEQEL CCCCCHHHHHHHHHH	45.13	25367039
338	Phosphorylation	ECERRGLSSPNELQA HHHHCCCCCHHHHHH	46.72	24719451
339	Phosphorylation	CERRGLSSPNELQAA HHHCCCCCHHHHHHH	36.47	26745281
358	Phosphorylation	RREGRRQSFGGSLFA CCCCCCCCCCCCEEE	24.85	25266776
362	Phosphorylation	RRQSFGGSLFAYSPS CCCCCCCCEEEECCC	22.24	26745281
366	Phosphorylation	FGGSLFAYSPSGAHS CCCCEEEECCCCCCC	17.49	30635358
367	Phosphorylation	GGSLFAYSPSGAHSM CCCEEEECCCCCCCC	14.79	19060867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ARI3A_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ARI3A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ARI3A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
BTK_MOUSE	Btk	physical	15456761

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ARI3A_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127, AND MASSSPECTROMETRY.	19367708 [Abstract]