| UniProt ID | NACC2_MOUSE | |
|---|---|---|
| UniProt AC | Q9DCM7 | |
| Protein Name | Nucleus accumbens-associated protein 2 | |
| Gene Name | Nacc2 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 586 | |
| Subcellular Localization | Nucleus. Predominantly associated with chromatin.. | |
| Protein Description | Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53 (By similarity).. | |
| Protein Sequence | MSQMLHIEIPNFGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPGTVPPACFQQILSFCYTGKLTMAASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSPHCDSQTAMIEDASSEPQSPCNQLQPATAAYVTSPSVPIPLLTRVKHEAMEMPPASGPGLASKRPLETGPRDGVAVATGAAGTPGTAPLKLPRVSYYGVPSLATLIPSIQQVPYPPGERTSPGASSLPTTDSPTSYHNEEDEEDDEAYDTMVEEQYGQMYIKATGNYAVQEKPEPVPLESRSCVLIRRDLVALPASLISQIGYRCHPKLYSEGDPGEKLELVAGSGVYITRGQLMNCHLCAGVKHKVLLRRLLATFFDRNTLANSCGTGIRSSTSDPSRKPLDSRVLNAVKLYCQNFAPSFKESEMNVIAADMCTNARRVRKRWLPKIKSMLPEGVEMYRSVMGASAASLPLDPEFPSAAPQVFEQRIYAERRSDAATIVALRTDAVNVDLSTSANPAFEANEEVDGGGSVIQEVAAPEQLPADGQSSPQAFEQGNTSSSRPQTPVATATRRPEGTYAGTL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 29 | Phosphorylation | EQRLLGLYCDVSIVV HHHHHHEECCEEEEE | 5.70 | 21454597 | |
| 33 | Phosphorylation | LGLYCDVSIVVKGQA HHEECCEEEEECCCH | 9.09 | 21454597 | |
| 91 | Phosphorylation | FCYTGKLTMAASEQL HHHHCCCCCCCCCHH | 14.30 | 25293948 | |
| 95 | Phosphorylation | GKLTMAASEQLVVMY CCCCCCCCCHHEEEE | 19.14 | 25293948 | |
| 102 | Phosphorylation | SEQLVVMYTAGFLQI CCHHEEEEEHHHHHH | 5.05 | 25293948 | |
| 103 | Phosphorylation | EQLVVMYTAGFLQIQ CHHEEEEEHHHHHHH | 11.38 | 25293948 | |
| 181 | Phosphorylation | AMEMPPASGPGLASK HHCCCCCCCCCCCCC | 51.82 | 21659604 | |
| 203 | Phosphorylation | RDGVAVATGAAGTPG CCCEEEEECCCCCCC | 22.28 | 28066266 | |
| 208 | Phosphorylation | VATGAAGTPGTAPLK EEECCCCCCCCCCCC | 17.51 | 28066266 | |
| 211 | Phosphorylation | GAAGTPGTAPLKLPR CCCCCCCCCCCCCCC | 26.72 | 28066266 | |
| 409 | Phosphorylation | PSRKPLDSRVLNAVK CCCCCCCHHHHHHHH | 31.78 | 19854140 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NACC2_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NACC2_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NACC2_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of NACC2_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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