ERCC8_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ERCC8_MOUSE
• UniProt AC: Q8CFD5
• Protein Name: DNA excision repair protein ERCC-8
• Gene Name: Ercc8
• Organism: Mus musculus (Mouse).
• Sequence Length: 397
• Subcellular Localization: Nucleus.
• Protein Description: Involved in transcription-coupled nucleotide excision repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. It is the substrate-recognition component of the CSA complex (DCX(ERCC8) complex) which promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair..
• Protein Sequence: MLSFLSARQSGLEDPLRLRRAQSTRRVLGLELNKDRDVERIHGSGVNTLDIEPVEGRYMLSGGSDGVVVLYDLENASRQPHYTCKAVCSVGRSHPDVHKYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQAADVFNFEETVYSHHMSPAATKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRHDYILATASADSRVKLWDVRRASGCLLTLDQHNGKKSQAAESANTAHNGKVNGLCFTSDGLHLLTIGTDNRMRLWNSSSGDNTLVNYGKVCNDSRKGLQFAVSCGCSSEFVFVPHGSTIAVYAVHSGERLAMLKGHYKSVDCCVFQPNFQELYSGSRDCNILAWVPPSYEPVPDDDDEAPAKSQLNPAFADAWSSSDEDG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
391	Phosphorylation	PAFADAWSSSDEDG- HHHHHHHCCCCCCC-	22.99	-
392	Phosphorylation	AFADAWSSSDEDG-- HHHHHHCCCCCCC--	30.98	-
393	Phosphorylation	FADAWSSSDEDG--- HHHHHCCCCCCC---	39.23	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ERCC8_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ERCC8_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ERCC8_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SSBP3_MOUSE	Ssbp3	physical	20211142
WWTR1_MOUSE	Wwtr1	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.