SSBP3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SSBP3_MOUSE
• UniProt AC: Q9D032
• Protein Name: Single-stranded DNA-binding protein 3
• Gene Name: Ssbp3
• Organism: Mus musculus (Mouse).
• Sequence Length: 388
• Subcellular Localization: Nucleus.
• Protein Description: May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region..
• Protein Sequence: MFAKGKGSAVPSDGQAREKLALYVYEYLLHVGAQKSAQTFLSEIRWEKNITLGEPPGFLHSWWCVFWDLYCAAPERRDTCEHSSEAKAFHDYSAAAAPSPVLGNIPPNDGMPGGPIPPGFFQGPPGSQPSPHAQPPPHNPSSMMGPHSQPFMSPRYAGGPRPPIRMGNQPPGGVPGTQPLLPNSMDPTRQQGHPNMGGSMQRMNPPRGMGPMGPGPQNYGSGMRPPPNSLGPAMPGINMGPGAGRPWPNPNSANSIPYSSSSPGTYVGPPGGGGPPGTPIMPSPADSTNSSDNIYTMINPVPPGGSRSNFPMGPGSDGPMGGMGGMEPHHMNGSLGSGDIDGLPKNSPNNISGISNPPGTPRDDGELGGNFLHSFQNDNYSPSMTMSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MFAKGKGS -------CCCCCCCC	7.13	-
155	Asymmetric dimethylarginine	SQPFMSPRYAGGPRP CCCCCCCCCCCCCCC	26.99	-
155	Methylation	SQPFMSPRYAGGPRP CCCCCCCCCCCCCCC	26.99	-
161	Methylation	PRYAGGPRPPIRMGN CCCCCCCCCCCCCCC	53.56	24129315
161	Asymmetric dimethylarginine	PRYAGGPRPPIRMGN CCCCCCCCCCCCCCC	53.56	-
165	Asymmetric dimethylarginine	GGPRPPIRMGNQPPG CCCCCCCCCCCCCCC	32.50	-
165	Methylation	GGPRPPIRMGNQPPG CCCCCCCCCCCCCCC	32.50	24129315
347	Phosphorylation	IDGLPKNSPNNISGI CCCCCCCCCCCCCCC	34.82	25521595
352	Phosphorylation	KNSPNNISGISNPPG CCCCCCCCCCCCCCC	32.00	24925903
355	Phosphorylation	PNNISGISNPPGTPR CCCCCCCCCCCCCCC	46.97	24925903
360	Phosphorylation	GISNPPGTPRDDGEL CCCCCCCCCCCCCCC	22.41	25521595
374	Phosphorylation	LGGNFLHSFQNDNYS CCHHHHHHHCCCCCC	30.58	25619855
380	Phosphorylation	HSFQNDNYSPSMTMS HHHCCCCCCCCCEEC	25.48	25619855
381	Phosphorylation	SFQNDNYSPSMTMSV HHCCCCCCCCCEECC	19.43	25619855
383	Phosphorylation	QNDNYSPSMTMSV-- CCCCCCCCCEECC--	22.42	25619855
385	Phosphorylation	DNYSPSMTMSV---- CCCCCCCEECC----	15.61	25619855
387	Phosphorylation	YSPSMTMSV------ CCCCCEECC------	18.60	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
360	T	Phosphorylation	Kinase	MAPK1	P63085	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SSBP3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SSBP3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAI14_MOUSE	Rai14	physical	20211142
KDM4C_MOUSE	Kdm4c	physical	20211142
CERS2_MOUSE	Cers2	physical	20211142
PWP1_MOUSE	Pwp1	physical	20211142
ISL2_MOUSE	Isl2	physical	20211142
SLF1_MOUSE	Ankrd32	physical	20211142
TLE6_MOUSE	Tle6	physical	20211142
ZSWM4_MOUSE	Zswim4	physical	20211142
MED16_MOUSE	Med16	physical	20211142
ZN592_MOUSE	Zfp592	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.