dbPTM

ISL2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ISL2_MOUSE
UniProt AC	Q9CXV0
Protein Name	Insulin gene enhancer protein ISL-2
Gene Name	Isl2
Organism	Mus musculus (Mouse).
Sequence Length	359
Subcellular Localization	Nucleus .
Protein Description	Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways..
Protein Sequence	MVDIIFHYPFLGAMGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLFGIKCAQCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRADHGLLLERAAAGSPRSPGPLPGARGLHLPDAGSGRQPSLRTHVHKQAEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHSDKASLQGLTGTPLVAGSPIRHENAVQGSAVEVQTYQPPWKALSEFALQSDLDQPAFQQLVSFSESGSLGNSSGSDVTSLSSQLPDTPNSMVPSPVET

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
154	Phosphorylation	LERAAAGSPRSPGPL HCHHHCCCCCCCCCC	13.39	24899341
157	Phosphorylation	AAAGSPRSPGPLPGA HHCCCCCCCCCCCCC	35.66	24899341
228	Phosphorylation	KEQLVEMTGLSPRVI HHHHHHHHCCCHHHH	22.82	28066266
231	Phosphorylation	LVEMTGLSPRVIRVW HHHHHCCCHHHHHHH	16.41	28066266
250	Phosphorylation	RCKDKKKSILMKQLQ CCCHHHHHHHHHHHH	29.81	-
262	Phosphorylation	QLQQQQHSDKASLQG HHHHHHHCCHHHHCC	36.15	-
279	Phosphorylation	GTPLVAGSPIRHENA CCCEECCCCCCCCCC	12.01	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ISL2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ISL2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ISL2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ISL2_MOUSE

Related Literatures of Post-Translational Modification