SLF1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SLF1_MOUSE
• UniProt AC: Q8R3P9
• Protein Name: SMC5-SMC6 complex localization factor protein 1 {ECO:0000312|MGI:MGI:2145448}
• Gene Name: Slf1 {ECO:0000312|MGI:MGI:2145448}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1054
• Subcellular Localization: Nucleus . Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Relocalizes with RAD18 to nuclear foci in response to DNA damage (PubMed:22036607). Colocalizes with RAD18 in the nucleus and to centrosomes (PubMed:15632077).
• Protein Description: Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions..
• Protein Sequence: MEDSATKHIIQMTGFKMEEKEALVKLLLKLDCTFIKSEKYKNCTHLIAERLCKSEKFLAACAAGKWVLTKDYIIHSAKSGRWLDETTYEWGYKIEKDSHYSPQMQSAPKRWREELKRTGAPGAFHRWKVVLLVRADKRSDSLVRVLEAGKANVILPKNSPSGITHVIASNARISAEREQENFKAPFYPIQYLGDFLLEKEIQNDEHSQISPAWTKYNNQEKGNDVGFPEMKGAGENMYRTQNKMENHNKNVSDRFVLSEHHKKKFKDFRKDIRSVKKRNTLRRHGLENQKETKKKDKNIQRSYILRKKNKKEGYCKTDDAHDTIRSMLKKRGHYREQKEMKNPLLTDGTKESKTKDVKTNMNLIEIKNALKKQIYKDIYRAQAVRYNCIRVDKQPVYNVEVKNSEFPRGILNLIENLIEGQFFKEAIEELSSLQAHYIPPVCLLHAILENVLQDKIDTFSGRYFHILSALLHLHPPWKSPAMLKYYLELFQCPTCMKGAWDFTEVLIRSCLFNEDFCHQISENISTKVVNLTLLKFFFNLLEGEVRHLSQKLCDWSDSQSLKVTEKAILHEIFWSGSETSGLLTKPVNMLLEWTIYSHKEKCKSNDVFKHELSYLLTGILGAAVDYWIFLGIQMGRNVIRHMSDDLGSYISLSCDDFSSKELEIFICSFSSSWLQMFVAEAIFKKLCLQGPTSTCTEPLSLQKIIDSYLPILGKMDIHGAGKMQSPKKLCQRPCLESQRALLMLNGAKRKQAEGRPELLELNRAKCSSSLKKLKKKSEELSCSKENCPSLVTKMNFHKTNLKGETALHRVCIKNQVEKLIILLSLPGIDINVKDNAGWTPLHEACNYGNTECVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQRGGPELLQQRNSKGELPLDYVLSPKDKEELFAITNIDDTVDNFHAKTQKHFYHQQLEFGSFLLSRMLINFCSIFDLSSEFILAFKGLGHLNELLMACNSDTEASNAHTDWLLDVYARNIKTLKKLPSVLKELPENLNVCPGVHTEALLVTLKMMCQSITELS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	Phosphorylation	TKDYIIHSAKSGRWL ECCEEEEECCCCCCC		51460091
79	Phosphorylation	YIIHSAKSGRWLDET EEEEECCCCCCCCCC		51460099
101	Phosphorylation	IEKDSHYSPQMQSAP CCCCCCCCCCHHCCC		28059163
139	Phosphorylation	LVRADKRSDSLVRVL EEECCCCCHHHHHHH		29899451
141	Phosphorylation	RADKRSDSLVRVLEA ECCCCCHHHHHHHHC		29899451
159	Phosphorylation	NVILPKNSPSGITHV EEEECCCCCCCCCHH		26824392
161	Phosphorylation	ILPKNSPSGITHVIA EECCCCCCCCCHHHH		26643407
164	Phosphorylation	KNSPSGITHVIASNA CCCCCCCCHHHHHCC		25293948
402	Sumoylation	PVYNVEVKNSEFPRG CEEEEEECCCCCCHH		28289178
458	Phosphorylation	VLQDKIDTFSGRYFH HHHHCHHHCCHHHHH		29472430
460	Phosphorylation	QDKIDTFSGRYFHIL HHCHHHCCHHHHHHH		29472430
725	Phosphorylation	HGAGKMQSPKKLCQR CCCCCCCCCHHHHCC		26745281
867	Phosphorylation	CPEVDLLTQVDGVTP CCCCCCEECCCCCCC		51460083

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SLF1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SLF1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SLF1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SLF1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.