PWP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PWP1_MOUSE
• UniProt AC: Q99LL5
• Protein Name: Periodic tryptophan protein 1 homolog
• Gene Name: Pwp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 501
• Subcellular Localization: Nucleus.
• Protein Description: May play an important role in cell growth and/or transcription..
• Protein Sequence: MNRSRQVTCVAWVRRGVAKETPDKVELSKEEVNRLIAEAKGKLQEEGGSEEEEAGNPSEDGMQSGPTQAPPRESLEDGDPQDDRTLDDDELAGYDLDNYDEEDNPDAETIGESLLGLTVYGSNDQDPYVTLKDTEQYEHEDFLIKPTDNLIVCGRAEQEQCNLEVHVYNQEEESFYVHHDILLSAYPLSVEWLNFDPSPDASTGNYIAVGNMTPVIEVWDLDIVDSLEPVFTLGSKLSKKKKKKGKKSSSAEGHTDAVLDLSWNKTVRNVLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHPFEAQTLISGSYDKSVALYDCRDPSQNHRQWRFSGQIERVTWNHFSPCHFLASTDDGFVYNLDARSDKPIFTLNAHNDEISGLDLSSQIKGCLVTASADKFVKIWDILGDRPSLIHSRDMKMGVLFCSSCCPDLPFVYAFGGQKEGLRVWDISTVSSVNEAFGRRERLVIGGTKGLSVSGPCGSRSPQQTPMES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	RRGVAKETPDKVELS ECCCCCCCCCCCCCC	35.76	28066266
49	Phosphorylation	KLQEEGGSEEEEAGN HHHHCCCCCCHHCCC	53.33	27087446
58	Phosphorylation	EEEAGNPSEDGMQSG CHHCCCCCCCCCCCC	52.93	25521595
62	Oxidation	GNPSEDGMQSGPTQA CCCCCCCCCCCCCCC	4.42	17242355
64	Phosphorylation	PSEDGMQSGPTQAPP CCCCCCCCCCCCCCC	37.54	25619855
67	Phosphorylation	DGMQSGPTQAPPRES CCCCCCCCCCCCHHH	40.67	25619855
74	Phosphorylation	TQAPPRESLEDGDPQ CCCCCHHHCCCCCCC	38.04	25338131
85	Phosphorylation	GDPQDDRTLDDDELA CCCCCCCCCCHHHHC	41.35	-
249	Phosphorylation	KKKGKKSSSAEGHTD HCCCCCCCCCCCCCH	42.31	25266776
300	Ubiquitination	RLTAHTDKVQTLQFH HHEECCCCCEEEEEC	37.08	22790023
367	Phosphorylation	STDDGFVYNLDARSD ECCCCEEEECCCCCC	14.03	22817900
407	Acetylation	LVTASADKFVKIWDI EEECCHHHHHHHHHH	52.34	22826441
481	Ubiquitination	RLVIGGTKGLSVSGP EEEECCCCCCEECCC	62.22	22790023
484	Phosphorylation	IGGTKGLSVSGPCGS ECCCCCCEECCCCCC	23.94	22942356
486	Phosphorylation	GTKGLSVSGPCGSRS CCCCCEECCCCCCCC	33.37	22942356
489	Glutathionylation	GLSVSGPCGSRSPQQ CCEECCCCCCCCCCC	9.85	24333276
491	Phosphorylation	SVSGPCGSRSPQQTP EECCCCCCCCCCCCC	35.98	27087446
493	Phosphorylation	SGPCGSRSPQQTPME CCCCCCCCCCCCCCC	28.85	27087446
497	Phosphorylation	GSRSPQQTPMES--- CCCCCCCCCCCC---	21.25	27149854
499	Oxidation	RSPQQTPMES----- CCCCCCCCCC-----	10.04	17242355
501	Phosphorylation	PQQTPMES------- CCCCCCCC-------	38.99	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PWP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PWP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PWP1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PWP1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, AND MASSSPECTROMETRY.
PubMed: 19144319

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49 AND SER-493, AND MASSSPECTROMETRY.
PubMed: 17242355

"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, AND MASSSPECTROMETRY.
PubMed: 15345747