CERS2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CERS2_MOUSE
• UniProt AC: Q924Z4
• Protein Name: Ceramide synthase 2
• Gene Name: Cers2
• Organism: Mus musculus (Mouse).
• Sequence Length: 380
• Subcellular Localization: Nucleus membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis (By similarity)..
• Protein Sequence: MLQTLYDYFWWERLWLPVNLTWADLEDKDGRVYAKASDLYITLPLALLFLVIRYFFELYVATPLAALLNVKEKTRLRAPPNATLEHFYQTSGKQPKQVEVDLLSRQSGLSGRQVERWFRRRRNQDRPSLLKKFREASWRFTYYLIAFVAGMAVTVDKPWFYDLRKVWEGYPIQSIIPSQYWYYMIELSFYWSLLFSIASDVKRKDFKEQIIHHVATIILLCFSWFANYVRAGTLIMALHDASDYLLESAKMFNYAGWKNTCNNLFIVFAIVFIITRLVIMPFWILHCTMIYPLELYPAFFGYYFFNFMMAVLQMLHIFWAYFILRMAHKFITGKLIEDERSDREETESSEGEETAAGAGAKSRLLANGHPILNNNHPKND

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	N-linked_Glycosylation	ERLWLPVNLTWADLE HHHCCEEEEEEHHCC	29.79	15823095
93	Ubiquitination	HFYQTSGKQPKQVEV HHHHCCCCCCCEEEE	64.29	22790023
96	Ubiquitination	QTSGKQPKQVEVDLL HCCCCCCCEEEEEHH	65.56	27667366
104	Phosphorylation	QVEVDLLSRQSGLSG EEEEEHHHCCCCCCH	35.25	28978645
107	Phosphorylation	VDLLSRQSGLSGRQV EEHHHCCCCCCHHHH	40.36	28978645
110	Phosphorylation	LSRQSGLSGRQVERW HHCCCCCCHHHHHHH	35.14	28978645
131	Ubiquitination	QDRPSLLKKFREASW CCCCHHHHHHHHHHH	55.98	27667366
341	Phosphorylation	KLIEDERSDREETES CHHCCCCCCCHHHCC	38.68	25521595
346	Phosphorylation	ERSDREETESSEGEE CCCCCHHHCCCHHCC	36.09	25521595
348	Phosphorylation	SDREETESSEGEETA CCCHHHCCCHHCCCC	40.90	25521595
349	Phosphorylation	DREETESSEGEETAA CCHHHCCCHHCCCCC	43.31	25521595
354	Phosphorylation	ESSEGEETAAGAGAK CCCHHCCCCCCCCHH	19.94	22802335

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CERS2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CERS2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CERS2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WWTR1_MOUSE	Wwtr1	physical	20211142
MAML1_MOUSE	Maml1	physical	20211142
TOX3_MOUSE	Tox3	physical	20211142
ZBTB9_MOUSE	Zbtb9	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Mammalian Lass6 and its related family members regulate synthesis ofspecific ceramides.";
Mizutani Y., Kihara A., Igarashi Y.;
Biochem. J. 390:263-271(2005).
Cited for: GLYCOSYLATION AT ASN-19, TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
PubMed: 15823095

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-341, AND MASSSPECTROMETRY.
PubMed: 19367708

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-346; SER-348 ANDSER-349, AND MASS SPECTROMETRY.
PubMed: 17242355

"A differential phosphoproteomic analysis of retinoic acid-treated P19cells.";
Smith J.C., Duchesne M.A., Tozzi P., Ethier M., Figeys D.;
J. Proteome Res. 6:3174-3186(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-341; THR-346; SER-348AND SER-349, AND MASS SPECTROMETRY.
PubMed: 17622165