TOX3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TOX3_MOUSE
• UniProt AC: Q80W03
• Protein Name: TOX high mobility group box family member 3
• Gene Name: Tox3
• Organism: Mus musculus (Mouse).
• Sequence Length: 575
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region (By similarity)..
• Protein Sequence: MDVRFYPAAAGDPAGLDFAQCLGYYGYSKLGNNNYMNMAEANNAFFAASEQTFHTPSLGDEEFEIPPITPPPESDPTLGMPDALLPFQTLSDPLPSQGTEFTPQFPPQSLDLPSITISRNLVEQDGVLHSNGLHMDQSHTQVSQYRQDPSLVMRSIVHMTDGARSGIMPPAQLTTINQSQLSAQLGLNLGGANVSHTSPSPPASKSATPSPSSSINEEDADDANRAIGEKRTAPDSGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYRASLVSKAAAESAEAQTIRSVQQTLASTNLTSSLLLNTSLSQHGTVPASPQTLPQSLPRSIAPKPLTMRLPMSQIVTSVTIAANMPSNIGAPLISSMGTTMVGSATSTQVSPSVQTQQHQMQLQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQQHLQQQLSQQQLQQQLQQHLQLQQLQHMQHQSQPSPRQHSPVTSQITSPIPAIGSPQPASQQHQPQIQSQTQTQVLPQVSIF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
206	Phosphorylation	PSPPASKSATPSPSS CCCCCCCCCCCCCCC	34.57	24759943
210	Phosphorylation	ASKSATPSPSSSINE CCCCCCCCCCCCCCH	32.81	24759943
212	Phosphorylation	KSATPSPSSSINEED CCCCCCCCCCCCHHH	40.84	24759943
249	Acetylation	TPKKKKKKDPNEPQK CCCCCCCCCCCCCCC	83.64	8277279
280	Phosphorylation	KGQNPNATFGEVSKI CCCCCCCCHHHHHHH	38.52	-
285	Phosphorylation	NATFGEVSKIVASMW CCCHHHHHHHHHHHH	16.62	-
338	Phosphorylation	AESAEAQTIRSVQQT HHHHHHHHHHHHHHH	25.96	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TOX3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TOX3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TOX3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TOX3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.