UniProt ID | MAML1_MOUSE | |
---|---|---|
UniProt AC | Q6T264 | |
Protein Name | Mastermind-like protein 1 | |
Gene Name | Maml1 {ECO:0000312|EMBL:AAS07633.1, ECO:0000312|MGI:MGI:1890504} | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 1020 | |
Subcellular Localization | Nucleus speckle . Nuclear, in a punctate manner. | |
Protein Description | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.. | |
Protein Sequence | MVLPTCPMAEFALPRHSAVMERLRRRIELCRRHHSTCEARYEAVSPERLELERQHTFALHQRCIQAKAKRAGKHRQPPAAATAPVAAPAPASAPAAARLDAADGPEHGRPVAHLHDTVKRSLDSAASPQNGDQPNGYGDLFPGHKKTRREAPLGVSVSANGLPPASPLGQPDKPSGGDTLQTAGKHSLGLDPINKKCLADSGIHLNGGSNSSEPFPLSLSKELKQEPVDDLPCMIAGAGGSVAQSNLMPDLNLNEQEWKELIEELNRSVPDEDMKDLFTEDFEEKKDPEPPGSATQTPLAQDINIKTEFSPAAFEQEQLGSPQVRAGSAGQTFLGASSAPVGTDSPSLGSSQTLFHTTSQPGVDNSSPNLMPASAQAQSAQRALTSVVLPSQGPGGASELSSAHQLQQIAAKQKREQMLQNPQQAAPAPGPGQLATWQQAGPSHSPLDVPYPMEKPASPSGYKQDFTNSKLLMMPGVNKSSPRPGGPYLQPSHSNLLSHQSPSNLNQNPVNNQGSVLDYGNTKPLSHYKADCGQGGPGSGQNKPALMAYLPQQLPHLSNEQNSLFLMKPKSGNMPFRSLVPPGQEQNPSSVPVAAPAASVGTQPTVSVASTHNSSPYLSSQQQAAVMKQHQLLLDQQKQREQQQQQLQQQQFLQRQHLLAEQEKQQFQRHLTRPPPQYQDPTQSTFPQQVGQFTGPSAAVPGMNNLGPSNSSCPRVFPQPGTLMSMGPGHAPVSSLPSSSGQQDRGVAQFTGSQSLPQNSLYGMASGLAQIVAQPPPQATSTHAHIPRQTNVGQNASTSAAYGQNSLGSASLSQQHSKGTLPPGLTKPQVPRVSAAMGSQNASWQHQGMPNLSSQTSGNSSVNPFTAAPSFHIQQAHLKLAGQQFSQAMPSRPMAPLSSAGAAGPMLPPVSAQQRNSAPASAPPQAAPQQGLPGLSPSGPELGAFGQSPTSQMSGRPGLHCAQAYPVRTMGQELPFAYSGQPGSSGLSSVAGHTDLIDSLLKNRTSEEWINELDDLLGSQ | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
41 | Phosphorylation | HSTCEARYEAVSPER CCHHHHHHHCCCHHH | 18.45 | 25777480 | |
45 | Phosphorylation | EARYEAVSPERLELE HHHHHCCCHHHHHHH | 28.26 | 26824392 | |
121 | Phosphorylation | LHDTVKRSLDSAASP HHHHHHHHHHHCCCC | 30.70 | 26160508 | |
124 | Phosphorylation | TVKRSLDSAASPQNG HHHHHHHHCCCCCCC | 30.90 | 26160508 | |
127 | Phosphorylation | RSLDSAASPQNGDQP HHHHHCCCCCCCCCC | 27.08 | 19144319 | |
145 | Acetylation | GDLFPGHKKTRREAP CCCCCCCCCCCCCCC | 62.85 | 22902405 | |
166 | Phosphorylation | ANGLPPASPLGQPDK CCCCCCCCCCCCCCC | 26.82 | 28285833 | |
195 | Acetylation | LGLDPINKKCLADSG CCCCCCCCHHHHCCC | 45.65 | 22902405 | |
293 | Phosphorylation | KDPEPPGSATQTPLA CCCCCCCCCCCCCCH | 33.64 | 25338131 | |
307 | Phosphorylation | AQDINIKTEFSPAAF HHCCCCCCCCCHHHH | 38.17 | 25777480 | |
310 | Phosphorylation | INIKTEFSPAAFEQE CCCCCCCCHHHHHHH | 13.85 | 27149854 | |
321 | Phosphorylation | FEQEQLGSPQVRAGS HHHHHHCCCCEECCC | 22.28 | 21082442 | |
367 | Phosphorylation | QPGVDNSSPNLMPAS CCCCCCCCCCCCCHH | 24.86 | - | |
458 | Phosphorylation | YPMEKPASPSGYKQD CCCCCCCCCCCCCCC | 28.29 | 27841257 | |
460 | Phosphorylation | MEKPASPSGYKQDFT CCCCCCCCCCCCCCC | 52.86 | 29550500 | |
827 | Acetylation | TLPPGLTKPQVPRVS CCCCCCCCCCCCCCH | 38.20 | 23806337 | |
1019 | Phosphorylation | ELDDLLGSQ------ HHHHHHCCC------ | 32.46 | 19144319 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MAML1_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MAML1_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MAML1_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
TLE6_MOUSE | Tle6 | physical | 20211142 | |
HDA10_MOUSE | Hdac10 | physical | 20211142 |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1019, AND MASSSPECTROMETRY. | |
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127, AND MASSSPECTROMETRY. |