ASH1L_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASH1L_MOUSE
• UniProt AC: Q99MY8
• Protein Name: Histone-lysine N-methyltransferase ASH1L
• Gene Name: Ash1l
• Organism: Mus musculus (Mouse).
• Sequence Length: 2958
• Subcellular Localization: Nucleus. Cell junction, tight junction. Chromosome. The relevance of tight junction localization is however unclear..
• Protein Description: Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me)..
• Protein Sequence: MDPRNTAMLGLGSDSEGFSRKSPSTINPGTLASKREAEIEGATEEEDPRKRNRERGTEAGKEDGSTDAQQQFSVKETNFSEGNLKLKIGLQAKRTKKPPKNLENYVCRPAIKTTIKHSRKALKSGKMTDEKNEHCPSKWDSSKLFKKAGDATAIDCQAEESIHLHSQGESNPLSKKLSPVHSQMADYISAAPSLVGSRDPDIKDRALLNGGTSVTEKLAQLIATCPPSKSSKAKPKKLGTGTTVGLVSKDLIRKPGVGSIAGIIHKDLIKKPALSTAVGLVTKDPGKKPMFNAAVGLINKDSVKKLGTGTTAVFINKDLGKKPGAITTVGLLSKESGKKLGIGIVPGLVNKESGKKLGLGTVVGLVNKELGKKLSSTVGLVAKDVTKKIVASSAMGLVNKDIGKKLLNCPMAGQLGSKDALNLKSEALLPTQEQLKASCSANISNHDSQELPESLKDSATGKAFEKSVMRHSKESMLEKFSVRKEITNLEKEMFNEGTCIQQDNFSSSERGAFETSKHEKQPPVYCTSPDFQIGGASDASTAKSPFSAVGESNLPSSSPTVSVNPVTRSPPEASSQLVPNPLLLNSTAEQMEEISESIGKSQFTAESTHLNVGHRSLGHSLSIECKGIDKELNESKNTHLDIPRISSSLGKKPSLTSDSGIHAITPSVVNFTSLFSNKPFLKLGAVTAPDKHCQVAESLSSSFQSKPLKKRKGRKPRWTKVVARSTCRSPKGLDLERSELFKNVSCSSLSNSSEPAKFMKTIGASSFVDHDFLKRRLPKLSKSSAPSLALLTDSEKPSHKSFITHKLSSSMCVTSDLLSDIYKPKRGRPKSKEMPQLEGPPKRTLKIPASKVFSLQSKEEQEPPILQPEIEIPSFKQSLSVSPFPKKRGRPKRQMRSPVKMKPPVLSVAPFVATESPSKLESESENHRSSSDFFESEDQLQDTDDLDDSHRQSVCSMSDLEMEPDKKISKRNNGQLMKTIIRKINKMKTLKRKKLLNQILSSSVESSNKGKVQSKLHNTVSSLAATFGSKLGQQINVSKKGTIYIGKRRGRKPKTVLNGLLSGSPASLAVLEQTAQQAAGSALGQILPPLLPSPASSSEILPSPICSQSSGTSGGQSPVSSDAGFVEPSSVPYLHVHSRQGSMIQTLAMKKASKGRRRLSPPTLLPNSPSHLSELTSLKEATPSPVSESHSDETIPSDSGIGTDNNSTSDRAEKFCGQKKRRHSFEHISLIPPETSTVLNSLKEKHKHKCKRRSHDYLSYDKMKRQKRKRKKKYPQLRNRQDPDFIAELEELISRLSEIRITHRSHHFIPRDLLPTIFRINFNSFYTHPSFPLDPLHYIRKPDLKKKRGRPPKMREAMAEMPFMHSLSFPLSSTGFYPSYGMPYSPSPLTAAPIGLGYYGRYPPTLYPPPPSPSFTTPLPPPSYMHAGHLLLNPTKYHKKKHKLLRQEAFLTTSRTPLLSMSTYPSVPPEMAYGWMVEHKHRHRHKHREHRSEQPQVSMDSGSSRSVLESLKRYRFGKDTVGDRYKHKEKHRCHMSCPHLSPSKNLINREEQWVSREPSESSSLALGLQTPLQIDCSESSPSLSLGGFTPNSEPASSDEHMNLFTSAIGSCRVSNPNSSCRKKLTDSPGLFPVQDTALNRPHRKEPLPSSERAIQSLAGSQSASDKPSQRSSESTNCSPTRKRSSSESTSSTVNGVPSRSPRLVASMDDSVDSLLQRIVHHDEQESMEKNGDASITTVSAPPSSSPGHSYSKERALGKSDSLLVPAVPNDSCSNIPLLSEKSASRCSPHHIKRSVVEAMQRQARKMCNYDKILATKKNLDHVNKILKAKKLQRQARTGNNFVKRRPGRPRKCPLQAVVSMQAFQAAQFVSPELNEGEDMSLHLSPDTVTDVIEAVVQSVNLTSEHKKGVKRKNWLLEEQTRKKQKTVPEEEEQENNKSFIETPVEIPSPLETPAEPSEPENTLQPVLALIPREKKAPRPPKKKYQRAGLYSDVYKTIDPKSRLIQLKKEKLEYTPGEHEYGLFPAPIHVGKYLRQKRIDFQLPYDILWQWKHNQLYKKPDVPLYKKIRSNVYVDVKPLSGYEATTCNCKKPDDDTRKGCGDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQRMNGLPSHKGSQSSSTHRKSARAKEKRKSKHKLKKRKGHPSEEPSENINTPTRLTPQLQMKPMSNRERNFVLKHHVFLVRNWEKIHQKQEEVKHTRDIHSASLYTRWNGLCRDDGNIKSDVFMTQFSALQTARSVRTRRLAAAEENLEVARAARLAQIFKEICDGIISYRDSSQQTLAAPLLNLPPKKKNADYYEKISDPLDLSTIEKQILIGYYKTVEAFDADMLKVFRNAEKYYGRKSPIGRDVCRLRKAYYSARHEASAQIDEIVGETASEADSSETSVSEKESGHEKDDDVIRCICGLYKDEGLMIQCDKCMVWQHCDCMGVNTDVEHYLCEQCDPRPVDREVPMIPRPHYAQPGCVYFICLLRDDLLLRQGDCVYLMRDSRRTPDGHPVRQSYRLLSHINRDKLDIFRIEKLWKNEKEERFAFGHHYFRPHETHHSPSRRFYHNELFRVPLYEIIPLEAVVGTCCVLDLYTYCKGRPKGIKEQDVYICDYRLDKSAHLFYKIHRNRYPVCTKPYAFDHFPKKLTPKRDFSPHYVPDNYKRNGGRSSWKSERSKPPLKDLGQEDDALPLIEEVLASQEQAAREVPSPEEPDQERATGDIGDAEKKPEESSQEAQLASTPEERRHSQRERLNQILLNLLEKIPGKNAIDVTYLLEEGSGRKLRRRTLFIPENSFRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MDPRNTAMLGLGS --CCCCCCCCCCCCC	18.09	26643407
13	Phosphorylation	TAMLGLGSDSEGFSR CCCCCCCCCCCCCCC	42.90	24759943
15	Phosphorylation	MLGLGSDSEGFSRKS CCCCCCCCCCCCCCC	41.12	26643407
19	Phosphorylation	GSDSEGFSRKSPSTI CCCCCCCCCCCCCCC	50.05	26643407
22	Phosphorylation	SEGFSRKSPSTINPG CCCCCCCCCCCCCCC	23.99	28507225
24	Phosphorylation	GFSRKSPSTINPGTL CCCCCCCCCCCCCCC	49.35	28066266
25	Phosphorylation	FSRKSPSTINPGTLA CCCCCCCCCCCCCCC	28.32	28066266
166	Phosphorylation	EESIHLHSQGESNPL CEEEECCCCCCCCCC	46.36	22871156
170	Phosphorylation	HLHSQGESNPLSKKL ECCCCCCCCCCHHCC	51.04	22871156
174	Phosphorylation	QGESNPLSKKLSPVH CCCCCCCHHCCCHHH	29.06	22871156
178	Phosphorylation	NPLSKKLSPVHSQMA CCCHHCCCHHHHHHH	33.48	25159016
182	Phosphorylation	KKLSPVHSQMADYIS HCCCHHHHHHHHHHH	23.14	25159016
187	Phosphorylation	VHSQMADYISAAPSL HHHHHHHHHHHCHHH	6.29	29550500
189	Phosphorylation	SQMADYISAAPSLVG HHHHHHHHHCHHHCC	16.49	22817900
193	Phosphorylation	DYISAAPSLVGSRDP HHHHHCHHHCCCCCC	30.84	22817900
283	Acetylation	TAVGLVTKDPGKKPM CEEEEEECCCCCCCC	55.22	22826441
373	Acetylation	VNKELGKKLSSTVGL HCHHHHHHHHHHHHH	52.37	-
475	Phosphorylation	VMRHSKESMLEKFSV HHHHCHHHHHHHHHH	32.19	20495213
558	Phosphorylation	ESNLPSSSPTVSVNP CCCCCCCCCCEEECC	29.00	29514104
620	Phosphorylation	GHRSLGHSLSIECKG CCCHHCCCEEEEEEC	23.24	29514104
622	Phosphorylation	RSLGHSLSIECKGID CHHCCCEEEEEECCC	21.25	25266776
842	Ubiquitination	PQLEGPPKRTLKIPA CCCCCCCCCCCCCCH	62.24	-
880	Phosphorylation	PSFKQSLSVSPFPKK CCCCCCCCCCCCCCC	26.29	27742792
882	Phosphorylation	FKQSLSVSPFPKKRG CCCCCCCCCCCCCCC	19.90	27742792
897	Phosphorylation	RPKRQMRSPVKMKPP CCCCCCCCCCCCCCC	28.80	25338131
914	Phosphorylation	SVAPFVATESPSKLE EECCEEECCCHHHCC	31.52	29550500
916	Phosphorylation	APFVATESPSKLESE CCEEECCCHHHCCCC	30.07	29550500
918	Phosphorylation	FVATESPSKLESESE EEECCCHHHCCCCCC	60.18	29550500
922	Phosphorylation	ESPSKLESESENHRS CCHHHCCCCCCCCCC	57.78	29514104
958	Phosphorylation	RQSVCSMSDLEMEPD HHHHHCHHHCCCCCC	23.81	-
1038	Phosphorylation	LGQQINVSKKGTIYI HHCEEECCCCCEEEE	24.94	28059163
1047	Methylation	KGTIYIGKRRGRKPK CCEEEECCCCCCCCC	29.39	-
1160	Phosphorylation	SKGRRRLSPPTLLPN HCCCCCCCCCCCCCC	27.33	26824392
1163	Phosphorylation	RRRLSPPTLLPNSPS CCCCCCCCCCCCCHH	44.29	26745281
1168	Phosphorylation	PPTLLPNSPSHLSEL CCCCCCCCHHHHHHH	26.32	26824392
1170	Phosphorylation	TLLPNSPSHLSELTS CCCCCCHHHHHHHHC	36.56	26745281
1173	Phosphorylation	PNSPSHLSELTSLKE CCCHHHHHHHHCCCC	25.74	29550500
1176	Phosphorylation	PSHLSELTSLKEATP HHHHHHHHCCCCCCC	28.14	26643407
1177	Phosphorylation	SHLSELTSLKEATPS HHHHHHHCCCCCCCC	50.50	26643407
1184	Phosphorylation	SLKEATPSPVSESHS CCCCCCCCCCCCCCC	33.31	25338131
1218	Methylation	RAEKFCGQKKRRHSF HHHHHCCCCCCCCCC	49.64	-
1224	Phosphorylation	GQKKRRHSFEHISLI CCCCCCCCCCCCCCC	30.44	26643407
1229	Phosphorylation	RHSFEHISLIPPETS CCCCCCCCCCCCCHH	23.35	26643407
1254	Phosphorylation	KHKCKRRSHDYLSYD CCCCCCCCCCCCCHH	25.41	25293948
1257	Phosphorylation	CKRRSHDYLSYDKMK CCCCCCCCCCHHHHH	7.66	25293948
1259	Phosphorylation	RRSHDYLSYDKMKRQ CCCCCCCCHHHHHHH	25.67	25293948
1260	Phosphorylation	RSHDYLSYDKMKRQK CCCCCCCHHHHHHHH	19.58	25293948
1316	Phosphorylation	IPRDLLPTIFRINFN CCHHHHCCEEEEECC	32.49	-
1345	Acetylation	YIRKPDLKKKRGRPP HCCCCCHHHHCCCCH	64.72	7631135
1452	Phosphorylation	LRQEAFLTTSRTPLL HHHHHHCCCCCCCCC	19.10	22807455
1536	Phosphorylation	EKHRCHMSCPHLSPS HHCCCCCCCCCCCCC	10.79	28066266
1541	Phosphorylation	HMSCPHLSPSKNLIN CCCCCCCCCCCCCCC	24.88	25159016
1543	Phosphorylation	SCPHLSPSKNLINRE CCCCCCCCCCCCCHH	30.69	28066266
1678	Phosphorylation	SSESTNCSPTRKRSS CCCCCCCCCCCCCCC	31.23	23684622
1684	Phosphorylation	CSPTRKRSSSESTSS CCCCCCCCCCCCCCC	41.05	25338131
1685	Phosphorylation	SPTRKRSSSESTSST CCCCCCCCCCCCCCC	42.00	25338131
1686	Phosphorylation	PTRKRSSSESTSSTV CCCCCCCCCCCCCCC	36.49	28973931
1698	Phosphorylation	STVNGVPSRSPRLVA CCCCCCCCCCCCCEE	42.88	26643407
1700	Phosphorylation	VNGVPSRSPRLVASM CCCCCCCCCCCEECC	20.79	26643407
1743	Phosphorylation	TTVSAPPSSSPGHSY EEEECCCCCCCCCCC	42.25	23984901
1744	Phosphorylation	TVSAPPSSSPGHSYS EEECCCCCCCCCCCC	46.45	23984901
1745	Phosphorylation	VSAPPSSSPGHSYSK EECCCCCCCCCCCCH	38.96	23984901
1749	Phosphorylation	PSSSPGHSYSKERAL CCCCCCCCCCHHHHC	36.70	23984901
1750	Phosphorylation	SSSPGHSYSKERALG CCCCCCCCCHHHHCC	20.35	23984901
1751	Phosphorylation	SSPGHSYSKERALGK CCCCCCCCHHHHCCC	30.93	22942356
1787	Phosphorylation	EKSASRCSPHHIKRS HHHHCCCCHHHHHHH	26.59	29899451
1809	Phosphorylation	QARKMCNYDKILATK HHHHHCCHHHHHHCC	17.43	28576409
1990	Phosphorylation	KYQRAGLYSDVYKTI HHCCCCCCCCHHHHC	11.25	28978645
1991	Phosphorylation	YQRAGLYSDVYKTID HCCCCCCCCHHHHCC	26.16	28978645
1994	Phosphorylation	AGLYSDVYKTIDPKS CCCCCCHHHHCCCHH	13.86	28978645
2001	Phosphorylation	YKTIDPKSRLIQLKK HHHCCCHHHHHHHHH	37.39	28978645
2307	Acetylation	ARAKEKRKSKHKLKK HHHHHHHHHHHHHHH	74.95	23576753
2309	Acetylation	AKEKRKSKHKLKKRK HHHHHHHHHHHHHCC	48.03	23576753
2313	Acetylation	RKSKHKLKKRKGHPS HHHHHHHHHCCCCCC	56.17	23576753
2329	Phosphorylation	EPSENINTPTRLTPQ CCCCCCCCCCCCCHH	23.41	25619855
2331	Phosphorylation	SENINTPTRLTPQLQ CCCCCCCCCCCHHHC	35.95	25619855
2483	Phosphorylation	ISDPLDLSTIEKQIL CCCCCCHHHHHHHHH	27.31	30352176
2695	Ubiquitination	LDIFRIEKLWKNEKE CCEEEHHHHHCCCHH	58.22	-
2814	Phosphorylation	LTPKRDFSPHYVPDN CCCCCCCCCCCCCCC	18.30	29514104
2859	Phosphorylation	LIEEVLASQEQAARE HHHHHHHCHHHHHHH	30.04	25338131
2869	Phosphorylation	QAAREVPSPEEPDQE HHHHHCCCCCCCCHH	50.55	30635358
2934	Phosphorylation	KNAIDVTYLLEEGSG CCCEEEEEEECCCCC	14.78	22807455
2940	Phosphorylation	TYLLEEGSGRKLRRR EEEECCCCCCCEECC	38.41	22807455

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASH1L_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1218	Q	Methylation	Methylated at Gln-1218 by N6AMT1.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASH1L_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ASH1L_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.