DEDD_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DEDD_MOUSE
• UniProt AC: Q9Z1L3
• Protein Name: Death effector domain-containing protein
• Gene Name: Dedd
• Organism: Mus musculus (Mouse).
• Sequence Length: 318
• Subcellular Localization: Cytoplasm. Nucleus, nucleolus. Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli. Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colo
• Protein Description: A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3 (By similarity). Inhibits DNA transcription in vitro..
• Protein Sequence: MAGLKRRASQVWPEERGEQEHGLYSLHRMFDIVGTHLTHRDVRVLSFLFVDVIDDHERGLIRNGRDFLLALERQGRCDESNFRQVLQLLRIITRHDLLPYVTLKKRRAVCPDLVDKYLEETSIRYVTPRALSDPEPRPPQPSKTVPPHYPVVCCPTSGSQMCSKRPARGRTTLGSQRKRRKSVTPDPKEKQTCDIRLRVRAEYCQHETALQGNVFSNKQDPLERQFERFNQANTILKSRDLGSIICDIKFSELTYLDAFWRDYINGSLLEALKGVFITDSLKQAVGHEAIKLLVNVDEEDYELGRQKLLRNLMLQALP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	EQEHGLYSLHRMFDI CCCCCCHHHHHHHHH	23.81	24719451
121	Phosphorylation	VDKYLEETSIRYVTP HHHHHHHCCCCEECH	21.78	-
122	Phosphorylation	DKYLEETSIRYVTPR HHHHHHCCCCEECHH	14.35	-
125	Phosphorylation	LEETSIRYVTPRALS HHHCCCCEECHHHHC	13.65	-
127	Phosphorylation	ETSIRYVTPRALSDP HCCCCEECHHHHCCC	9.72	-
171	Phosphorylation	KRPARGRTTLGSQRK CCCCCCCCCCCCHHH	29.24	23608596
182	Phosphorylation	SQRKRRKSVTPDPKE CHHHCCCCCCCCHHH	29.43	24719451
184	Phosphorylation	RKRRKSVTPDPKEKQ HHCCCCCCCCHHHCC	29.12	28059163
267	Phosphorylation	WRDYINGSLLEALKG HHHHCCHHHHHHHHC	25.87	24759943

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DEDD_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DEDD_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DEDD_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DEDD_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.