dbPTM

CERS5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CERS5_MOUSE
UniProt AC	Q9D6K9
Protein Name	Ceramide synthase 5
Gene Name	Cers5
Organism	Mus musculus (Mouse).
Sequence Length	414
Subcellular Localization	Nucleus membrane Multi-pass membrane protein . Endoplasmic reticulum membrane Multi-pass membrane protein .
Protein Description	Dihydroceramide synthase. Catalyzes the acylation of sphingosine to form dihydroceramide, with high selectivity toward palmitoyl-CoA as acyl donor compared to stearoyl-CoA. Inhibited by fumonisin B1..
Protein Sequence	MATAAAETLGLLWGWLWSESFWLPQNVSWADLEGPGDGYGYPRAQHVLSVFPLAVCIFSVRMLFERFIAKPCALRVGIKDSPVNKVEPNDTLEKVFVSVTKYPDEKRLKGLSKQLDWSVRKIQCWFRHRRNQDKPPTLTKFCESMWRFTYYLCIFCYGIRFLWSMPWFWDTRQCWYNYPYQPLSRELYYYYITQLAFYWSLMFSQFIDVKRKDFLMMFIHHMIGIMLTTFSYVNNMVRVGALIFCLHDFADPLLEAAKMANYARRERLCTTLFVIFGAAFIVSRLAIFPLWILNTTLFESWEIIGPYPSWWLFNALLLILQVLHAIWSYLIVQTASKALSRGKVSKDDRSDVESSSEEEDETTHKNNLSGSSSSNGANCMNGYMGGSHLAEEQGTCKATGNLHFRASPHLHSCD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	N-linked_Glycosylation	ESFWLPQNVSWADLE CCCCCCCCCCHHHCC	28.05	15823095
81	Phosphorylation	LRVGIKDSPVNKVEP EECCCCCCCCCCCCC	26.25	28066266
345	Phosphorylation	ALSRGKVSKDDRSDV HHHCCCCCCCCCHHC	33.58	25159016
350	Phosphorylation	KVSKDDRSDVESSSE CCCCCCCHHCCCCCH	53.67	25159016
354	Phosphorylation	DDRSDVESSSEEEDE CCCHHCCCCCHHCCC	38.73	25159016
355	Phosphorylation	DRSDVESSSEEEDET CCHHCCCCCHHCCCC	28.41	25159016
356	Phosphorylation	RSDVESSSEEEDETT CHHCCCCCHHCCCCC	59.30	25159016
362	Phosphorylation	SSEEEDETTHKNNLS CCHHCCCCCCCCCCC	46.66	25159016
363	Phosphorylation	SEEEDETTHKNNLSG CHHCCCCCCCCCCCC	28.89	25159016
407	Phosphorylation	GNLHFRASPHLHSCD CCEEECCCCCCCCCC	14.48	25266776
412	Phosphorylation	RASPHLHSCD----- CCCCCCCCCC-----	26.75	25266776

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CERS5_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CERS5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CERS5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
WWTR1_MOUSE	Wwtr1	physical	20211142

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CERS5_MOUSE

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Mammalian Lass6 and its related family members regulate synthesis ofspecific ceramides."; Mizutani Y., Kihara A., Igarashi Y.; Biochem. J. 390:263-271(2005). Cited for: GLYCOSYLATION AT ASN-26, AND TISSUE SPECIFICITY.	15823095 [Abstract]