RPC6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RPC6_MOUSE
• UniProt AC: Q921X6
• Protein Name: DNA-directed RNA polymerase III subunit RPC6
• Gene Name: Polr3f
• Organism: Mus musculus (Mouse).
• Sequence Length: 316
• Subcellular Localization: Nucleus.
• Protein Description: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). Preferentially binds double-stranded DNA (dsDNA) (By similarity)..
• Protein Sequence: MAEVKVKVQPPDADPVEIENRIIELCHQFPHGITDQVIQNEMPHIEAQQRAVAINRLLSMGQLDLLRSNTGLLYRIKDSQNAGKMKGSDNQEKLVYQIIEDAGNKGIWSRDIRYKSNLPLTEINKILKNLESKKLIKAVKSVAASKKKVYMLYNLQPDRSVTGGAWYSDQDFESEFVEVLNQQCFKFLQSKAETARESKQNPVIQRNSSFASSHEVWKYICELGISKVELSMEDIETILNTLIYDGKVEMTIIAAKEGTVGSVDGHMKLYRAVNPILPPTGVVRAPCGLCPVFEDCHEGGEISPSNCIYMTEWLEF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEVKVKVQ ------CCEEEEEEC	30.23	-
59	Phosphorylation	VAINRLLSMGQLDLL HHHHHHHHHCHHHHH	26.01	27600695
121	Phosphorylation	YKSNLPLTEINKILK CCCCCCHHHHHHHHH	32.64	-
194	Phosphorylation	FLQSKAETARESKQN HHHHHHHHHHHHCCC	35.56	22871156

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RPC6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RPC6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RPC6_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RPC6_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.