| UniProt ID | KDM5D_MOUSE | |
|---|---|---|
| UniProt AC | Q62240 | |
| Protein Name | Lysine-specific demethylase 5D | |
| Gene Name | Kdm5d | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 1548 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks (By similarity).. | |
| Protein Sequence | MKPGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLNKIVMEEGGYEAICKDRRWARVAQRLNYPSGKNIGSLLRSHYERIIYPYEIFQSGANLVQCNTDPFDSEERDKEYKPHSIPLRQSVQPSKFSCYSRRGKRLQPEPEPTEEDIEKNPELKKLQIYGAGPKMIGLGLKAKEKTLRKKDSKQPDKEEVTCPATIVVKGEASEFGKVTSAFSDKNLNHSFEPCMKMTMQLRNNHSSTQFMNSYVCRICSRGDEVDKFLLCDGCSDNYHIFCLLPPLSEVPKGVWRCPKCILAECKSPPEAFGFEQATQEYTLQSFGEMADSFKADYFNMPVHMVPTEVVEKEFWRLVSSIEEDVTVEYGADIHSKEFGSGFPVNNSKWDLSPEEKEYAACGWNLNVMPVLDQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEDVMKRLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPVGRQCIEHYRRLRRYCVFSHEELICKMAAFPEKLDLNLAVAVHKEMFIMVQEERRLRKTLLEKGITEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDSLVCLSHINDLCKCSRNRQYLRYRYTLDELPAMLQKLKIRAESFDNWANKVQAALEVEDGRKRSFEELRALESEARDRRFPNSELLQRLKKCLTEAEACISQVLGLISNSEDRLQTPQITLTELQLLLKQMGTLPCTMHQIDEVKDVLQQVESYQIETREALTSLPYSLEILQSLMEKGQQLRVEVPEAHQLEELLEQAQWLDQVKQALAPSGQRHSLVIMKKLLVMGTKVASSPSVNKARAELQELLTIAECWEEKAHFCLKASQKHSPATLEVIIREAENIPVYLPNIQSLKEALTKAQAWIADVNEIQNGDHYPCLDDLEGLVAVGRDLPVELEELRQLENQVLTAHSWKEKASKTFLKKNSCYTLLEVLCPCADAGSVSTKRSRWIEKEMGLYKYDTELLGLSAQDLRDPGSVIMAFKEGEEKEKEGILHLRHINSAKPSPMSSSMNASATSICICGQVCAGVESLQCDLCHDWFHGQCVTVPHLLSSVRASHTSSQLLAWWEWDTKFLCPLCMRSRRPRLETILSLLVGLQRLSVRLPEGEALQCLTERAIGWQGRARQALASEDVTALLKQLEKSRQQLQDELRHKKPPTLPSGFAFDCLTENSGKDILKEEEELVLNEERIKSSEKIVPKESSCKGDKELLPSLLSQLTGPVLELPEATRAPLEELMMEGDLLEVTLDENYSIWQLLQAGQNPNLERIHTLLELEKPENPGNWSEEQTPERRRQRRQKVVLSRKGEDFTQKELESKRVKSSRIKPKEEKFQKPILGDNVLYTHHTEHTNILKEHINSVQGKDPSPSSSFPSLTPLLHLSYFHQQKL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 30 | Phosphorylation | EFRDPLGYIAKIRPI HHCCCCHHHCEECCC | 12.85 | 28059163 | |
| 82 | Ubiquitination | LEAQTRVKLNYLDQI HHHHHHHHHHHHHHH | 27.94 | 22790023 | |
| 143 | Phosphorylation | RVAQRLNYPSGKNIG HHHHHHCCCCCCCHH | 11.90 | 20139300 | |
| 147 | Ubiquitination | RLNYPSGKNIGSLLR HHCCCCCCCHHHHHH | 50.13 | 22790023 | |
| 151 | Phosphorylation | PSGKNIGSLLRSHYE CCCCCHHHHHHHHHH | 22.04 | 20139300 | |
| 239 | Phosphorylation | ELKKLQIYGAGPKMI HHHHEEEECCCCCCC | 6.48 | 19854140 | |
| 300 | Phosphorylation | SDKNLNHSFEPCMKM CCCCCCCCCHHHHHH | 30.17 | - | |
| 316 | Phosphorylation | MQLRNNHSSTQFMNS HHHHCCCCCHHHCHH | 36.88 | - | |
| 402 | Phosphorylation | SFGEMADSFKADYFN HHHHHHHHCCCCCCC | 21.07 | 29895711 | |
| 407 | Phosphorylation | ADSFKADYFNMPVHM HHHCCCCCCCCCCCC | 11.17 | - | |
| 889 | Phosphorylation | ETREALTSLPYSLEI CCHHHHHCCCHHHHH | 28.35 | - | |
| 893 | Phosphorylation | ALTSLPYSLEILQSL HHHCCCHHHHHHHHH | 20.00 | - | |
| 1082 | Phosphorylation | HSWKEKASKTFLKKN HHHHHHHHHHHHHHC | 43.21 | - | |
| 1355 | Phosphorylation | LNEERIKSSEKIVPK HCHHHHHCCCCCCCC | 41.16 | - | |
| 1471 | Phosphorylation | SRKGEDFTQKELESK HCCCCCCCHHHHHHH | 51.56 | 21659604 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KDM5D_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KDM5D_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KDM5D_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ZBTB9_MOUSE | Zbtb9 | physical | 20211142 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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