ZDHC6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZDHC6_MOUSE
• UniProt AC: Q9CPV7
• Protein Name: Palmitoyltransferase ZDHHC6 {ECO:0000305}
• Gene Name: Zdhhc6 {ECO:0000312|MGI:MGI:1914230}
• Organism: Mus musculus (Mouse).
• Sequence Length: 413
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein . When not palmitoylated, accumulates to dot-like structures in the endoplasmic reticulum.
• Protein Description: Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC. [PubMed: 25368151 Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins (By similarity Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum (By similarity Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function]
• Protein Sequence: MGIFCSVIKFENLQDLRRLCHWGPIIALGVIAICSTMAMIDSVLWYWPLHTTGGSVNFIMLINWTVMILYNYFNAMFAGPGFVPRGWKPEKSQDSMYLQYCKVCQAYKAPRSHHCRKCNRCVMKMDHHCPWINNCCGHQNHASFTLFLLLAPLGCTHAAFIFVMTMYTQLYNRLSFGWNTVKIDMSAARRDPPPIVPFGLAAFAATLFALGLALGTTIAVGMLFFIQIKIILRNKTSIESWIEEKAKDRIQYYQLDEVFIFPYDMGSKWKNFKQVFTWSGVPEGDGLEWPIREGCDQYSLTIEQLKQKADKRVRSVRYKVIEDYNGACCPLNRGVRTFFTSPCTEEPRIRLQKGEFILATRGLRYWLYGDKILDDSFIEGTSRVRGWFPRNCVEKCPCDGDSDPAPEGEKKNR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
165	Phosphorylation	AAFIFVMTMYTQLYN HHHHHHHHHHHHHHH	11.17	-
235	Acetylation	IKIILRNKTSIESWI HHHHHCCCCCHHHHH	36.90	7714461
245	Acetylation	IESWIEEKAKDRIQY HHHHHHHHHHHHCEE	48.20	7714471
328	S-palmitoylation	IEDYNGACCPLNRGV EECCCCCEECCCCCC	2.32	28826475
329	S-palmitoylation	EDYNGACCPLNRGVR ECCCCCEECCCCCCC	4.21	28826475
343	S-palmitoylation	RTFFTSPCTEEPRIR CEEEECCCCCCCEEE	8.18	28826475
376	Phosphorylation	GDKILDDSFIEGTSR CCEECCCCCCCCCCC	27.99	28066266
381	Phosphorylation	DDSFIEGTSRVRGWF CCCCCCCCCCCCCCC	10.69	28066266
382	Phosphorylation	DSFIEGTSRVRGWFP CCCCCCCCCCCCCCC	39.37	28066266
402	Phosphorylation	KCPCDGDSDPAPEGE CCCCCCCCCCCCCCC	51.53	30635358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZDHC6_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
328	C	Palmitoylation	Palmitoylation at Cys-328 accelerates the turnover of ZDHHC6.	28826475

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZDHC6_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SSBP3_MOUSE	Ssbp3	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.