UBIP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBIP1_MOUSE
• UniProt AC: Q811S7
• Protein Name: Upstream-binding protein 1
• Gene Name: Ubp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 540
• Subcellular Localization: Nucleus.
• Protein Description: Functions as a transcriptional activator in a promoter context-dependent manner. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2. Functions as a trans-acting factor that regulates the domestic strain CYP2D9 gene through specific association with the regulatory element SDI-A1. Binding to SDI-A1 depends on the type of nucleotide at position 299; binding is abolished by a nucleotide substitution at this position. Modulates the placental expression of CYP11A1 (By similarity)..
• Protein Sequence: MAWVLSMDEVIESGLVHDFDSSLSGIGQELGAGAYSMSDVLALPIFKQEDSSLSLEDEAKHPPFQYVMCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKMGDMPELSGKLVKSIIRVVFHDRRLQYTEHQQLEGWKWNRPGDRLLDLDIPMSVGIIDTRTNPSQLNAVEFLWDPAKRTSAFIQVHCISTEFTPRKHGGEKGVPFRIQVDTFKQNENGEYTDHLHSASCQIKVFKPKGADRKQKNDREKMEKRTAHEKEKYQPSYDTTILTEMRLEPIIEDAVEHEQKKSSKRTLPADYGDSLAKRGSCSPWPDTPTAYVNNSPSPAPTFTSSQPSTCSVPDSNSSSPNHQGDGAAQASGEQIQPSATTQETQQWLLKNRFSSYTRLFSNFSGADLLKLTKEDLVQICGAADGIRLYNSLKSRSVRPRLTIYVCQEQPSSTALQGQPQAAGSGGESGGGTPSVYHAIYLEEMVASEVARKLASVFNIPFHQINQVYRQGPTGIHILVSDQMVQNFQDETCFLFSTVKAENNDGIHIILK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	LVHDFDSSLSGIGQE CCCCCCCCCCCCCHH	28.53	-
51	Phosphorylation	PIFKQEDSSLSLEDE EEECCCCCCCCCCHH	32.21	21149613
52	Phosphorylation	IFKQEDSSLSLEDEA EECCCCCCCCCCHHH	34.01	25521595
54	Phosphorylation	KQEDSSLSLEDEAKH CCCCCCCCCCHHHHC	31.49	21149613
194	Phosphorylation	HCISTEFTPRKHGGE EEEECCCCCCCCCCC	18.89	-
293	Acetylation	HEQKKSSKRTLPADY HHHHHCCCCCCCCCC	57.40	19859179
300	Phosphorylation	KRTLPADYGDSLAKR CCCCCCCCCCHHHHC	25.57	20139300
306	Acetylation	DYGDSLAKRGSCSPW CCCCHHHHCCCCCCC	63.69	19859187
383	Phosphorylation	WLLKNRFSSYTRLFS HHHHCCCHHHHHHHH	21.14	25338131
390	Phosphorylation	SSYTRLFSNFSGADL HHHHHHHHCCCHHHH	41.37	22817900
393	Phosphorylation	TRLFSNFSGADLLKL HHHHHCCCHHHHHHC	37.00	16141072
425	Phosphorylation	YNSLKSRSVRPRLTI HHHHHCCCCCCCEEE	29.57	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBIP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBIP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBIP1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GMEB1_MOUSE	Gmeb1	physical	20211142
ZBTB3_MOUSE	Zbtb3	physical	20211142
GMEB2_MOUSE	Gmeb2	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.