GMEB2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GMEB2_MOUSE
• UniProt AC: P58929
• Protein Name: Glucocorticoid modulatory element-binding protein 2
• Gene Name: Gmeb2
• Organism: Mus musculus (Mouse).
• Sequence Length: 530
• Subcellular Localization: Nucleus . Cytoplasm. May be also cytoplasmic..
• Protein Description: Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter (By similarity)..
• Protein Sequence: MATPDVSVHMEEVVVVTTPDTAVDGSGVEEVKTVLVTTNLAPHGGDLTEDNMETENAAAAAAAAFTASSQLKEAVLVKMAEEGENLEAEIVYPITCGDSRANLIWRKFVCPGINVKCVQYDEHVISPKEFVHLAGKSTLKDWKRAIRMNGIMLRKIMDSGELDFYQHDKVCSNTCRSTKIDLSGARVSLSSPTSTEYIPLTPAAADVNGSPATITIETCEDPGDWTTTIGDDTFAFWRGLKDAGLLDEVIQEFQQELEETMKGLQQRVQDPPLQLRDAVLLNNIVQNFGMLDLVKKVLASHKCQMDRSREQYARDLAALEQQCDEHRRRAKELKHKSQHLSNVLMTLTPVPLPSPMKRPRLARATSGPAAMASQVLTQSAQIALSPGMPVSQLTSVPLGKVVSTLPSTVLGKGSPQAAPASSPASPLLGGYTVLASSGSTFPNAVEIHPDTSSLTVLSTAAMQDGSTVLKVVSPLQLLTLPGLGPTLQNVAQASPAGSTIVTMPTATATGPEEHTATIEVAAVAEDHEQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
107	Acetylation	RANLIWRKFVCPGIN HHHEEHHHHCCCCCC	27.44	22826441
337	Phosphorylation	AKELKHKSQHLSNVL HHHHHHHHHHHHHHH	23.66	18846507
341	Phosphorylation	KHKSQHLSNVLMTLT HHHHHHHHHHHHHCC	23.83	18846507
348	Phosphorylation	SNVLMTLTPVPLPSP HHHHHHCCCCCCCCC	17.05	18846507
354	Phosphorylation	LTPVPLPSPMKRPRL CCCCCCCCCCCCCCC	45.36	25266776
365	Phosphorylation	RPRLARATSGPAAMA CCCCCCCCCCHHHHH	28.76	26643407
366	Phosphorylation	PRLARATSGPAAMAS CCCCCCCCCHHHHHH	41.62	26643407
373	Phosphorylation	SGPAAMASQVLTQSA CCHHHHHHHHHHHHC	14.03	26643407
377	Phosphorylation	AMASQVLTQSAQIAL HHHHHHHHHHCHHHC	22.94	26643407
379	Phosphorylation	ASQVLTQSAQIALSP HHHHHHHHCHHHCCC	19.53	26643407
385	Phosphorylation	QSAQIALSPGMPVSQ HHCHHHCCCCCCHHH	15.47	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GMEB2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GMEB2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GMEB2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.