ANR49_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANR49_MOUSE
• UniProt AC: Q8VE42
• Protein Name: Ankyrin repeat domain-containing protein 49
• Gene Name: Ankrd49
• Organism: Mus musculus (Mouse).
• Sequence Length: 238
• Subcellular Localization: Nucleus .
• Protein Description: May have a role in spermatogenesis where it promotes autophagy in response to serum starvation, via the NF-kappaB pathway..
• Protein Sequence: MEKEKKDDEKPDLENSVDFSEQFNQLELLKTHGHLIPTGTQSLWVGNSDEDEEQEEKNEEWYQLQEKKMEKDPSKLLLWAAEKNRLATVQRLLSEKAAEVNTRDEDEYTPLHRAAYSGHIDVVRELVAKGADVHAVTVDGWTPLHSACKWNNTKVASFLLQHDADINAQTKGLLTPLHLAAGNRDSRDTLELLLMNRYIKPELKNNSQETASDIARRTSIYHYLFEIAEGCTNSSPPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	EKPDLENSVDFSEQF CCCCHHHCCCHHHHH	17.43	25619855
48	Phosphorylation	QSLWVGNSDEDEEQE CEEECCCCCCCHHHH	36.13	27180971
62	Phosphorylation	EEKNEEWYQLQEKKM HHHHHHHHHHHHHHC	11.56	25293948
198	Phosphorylation	ELLLMNRYIKPELKN HHHHHHHHCCHHHCC	14.32	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANR49_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANR49_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANR49_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ANR49_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48, AND MASSSPECTROMETRY.
PubMed: 19367708