RHG33_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RHG33_MOUSE
• UniProt AC: Q80YF9
• Protein Name: Rho GTPase-activating protein 33
• Gene Name: Arhgap33
• Organism: Mus musculus (Mouse).
• Sequence Length: 1305
• Subcellular Localization: Cell membrane . Translocates to the plasma membrane in response to insulin in adipocytes.
• Protein Description: May be involved in several stages of intracellular trafficking (By similarity). Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport..
• Protein Sequence: MLQAQKQSDPILPWGASWAGRGQTLRARSTDSLDGPGEGSVQPVPTTGGPGTKGKPGKRLSAPRGPFPRLADCAHFHYENVDFGHIQLLLSPEREGPSLSGENELVFGVQVTCQGRSWPVLRSYDDFRSLDAHLHRCIFDRRFSCLPELPPPPEGTRAAQMLVPLLLQYLETLSGLVDSNLNCGPVLTWMELDNHGRRLLLSEEASLNIPAVAAAHVVKRYTAQAPDELSFEVGDIVSVIDMPPTEDRSWWRGKRGFQVGFFPSECVELFTERPGPGLKADADSPLCGIPAPQGISSLTSAVPRPRGKLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVDGIYRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELESVGLGGAAAFREVRVQSVVVEFLLTHVEVLFSDTFTSAGLDPAGRCLLPRPKSLAGSSPSTRLLTLEEAQARTQGRLGTPTEPTTPKTPASPVERRKRERAEKQRKPGGSSWKTFFALGRGPSIPRKKPLPWLGGSRAPPQPSGSRPDTVTLRSAKSEESLSSQASGAGLQRLHRLRRPHSSSDAFPVGPAPAGSCESLSSSSSSSSSSSSSSSSESSAGGLGPLSGSPSHRTSAWLDDGDDLDFSPPRCLEGLRGLDFDPLTFRCSSPTPGDPAPPASPAPPASASAFPPRATPQALSPHGPTKPASPTALDISEPLAVSVPPAVLELLGAGGTPASATPTPALSPHLIPLLLRGAEAQLSDTCQQEISSKLAPTRGAPGQQSPGGMDSPLLPPPLPLLRPGGAPPPPPKNPARLMALALAERAQQVAEQQSQQEQGGTPPAPHSPFRRSLSLEVGGEPVGTSGSGIHPPSLAHPGAWAPGPPPYLPRQQSDGSLVRSQRPLGTSRRSPRGPSQVSAHLRASGAYRDAPEMAAQSPCSVPSQGSNPSFFSTPRECLPPFLGVPKQGLYSLGPPSFPPSSPAPVWRNSLGAPSALDRGENLYYEIGVGEGTSYSGPSRSWSPFRSMPPDRHNASYGMLGQSPPLHRSPDFLLSYPPPPSCFPPEHLTHSVSQRLARRPTRPEPLYVNLALGPRGPSPASSSSSSPPAHPRSRSDPGPPVPRLPQKQRAPWGPHTPHRVPGPWGSPEPFLLYRPAPPSYGRGGEVRGSLYRNGGHRGEGAGPPPPYPTPSWSLHSEGQTRSYC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	GQTLRARSTDSLDGP CCEEEEECCCCCCCC	35.27	19060867
30	Phosphorylation	QTLRARSTDSLDGPG CEEEEECCCCCCCCC	24.85	19060867
32	Phosphorylation	LRARSTDSLDGPGEG EEEECCCCCCCCCCC	28.57	25521595
40	Phosphorylation	LDGPGEGSVQPVPTT CCCCCCCCCCCCCCC	17.18	25293948
284	Phosphorylation	GLKADADSPLCGIPA CCCCCCCCCCCCCCC	22.84	-
556	Phosphorylation	CLLPRPKSLAGSSPS CCCCCCHHHCCCCCC	26.57	29899451
582	Phosphorylation	RTQGRLGTPTEPTTP HHCCCCCCCCCCCCC	31.46	22817900
584	Phosphorylation	QGRLGTPTEPTTPKT CCCCCCCCCCCCCCC	55.20	20415495
587	Phosphorylation	LGTPTEPTTPKTPAS CCCCCCCCCCCCCCC	49.88	28285833
588	Phosphorylation	GTPTEPTTPKTPASP CCCCCCCCCCCCCCH	33.24	28285833
594	Phosphorylation	TTPKTPASPVERRKR CCCCCCCCHHHHHHH	30.59	25521595
626	Phosphorylation	FALGRGPSIPRKKPL HCCCCCCCCCCCCCC	48.31	-
657	Phosphorylation	PDTVTLRSAKSEESL CCCEEEECCCCHHHH	43.06	25521595
660	Phosphorylation	VTLRSAKSEESLSSQ EEEECCCCHHHHHHH	46.44	25521595
663	Phosphorylation	RSAKSEESLSSQASG ECCCCHHHHHHHCCC	29.51	29899451
665	Phosphorylation	AKSEESLSSQASGAG CCCHHHHHHHCCCHH	29.68	22817900
666	Phosphorylation	KSEESLSSQASGAGL CCHHHHHHHCCCHHH	34.75	22817900
669	Phosphorylation	ESLSSQASGAGLQRL HHHHHHCCCHHHHHH	22.87	28059163
705	Phosphorylation	SCESLSSSSSSSSSS CCCCCCCCCCCCCCC	30.75	-
708	Phosphorylation	SLSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
710	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
711	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
712	Phosphorylation	SSSSSSSSSSSSSSE CCCCCCCCCCCCCCC	35.87	-
716	Phosphorylation	SSSSSSSSSSESSAG CCCCCCCCCCCCCCC	39.57	-
749	Phosphorylation	DGDDLDFSPPRCLEG CCCCCCCCCCHHHHC	33.39	25159016
887	Phosphorylation	RGAPGQQSPGGMDSP CCCCCCCCCCCCCCC	20.02	20415495
893	Phosphorylation	QSPGGMDSPLLPPPL CCCCCCCCCCCCCCC	14.46	22817900
936	Phosphorylation	QQVAEQQSQQEQGGT HHHHHHHHHHHHCCC	33.26	28066266
943	Phosphorylation	SQQEQGGTPPAPHSP HHHHHCCCCCCCCCH	32.68	25521595
949	Phosphorylation	GTPPAPHSPFRRSLS CCCCCCCCHHCCCEE	25.36	25521595
954	Phosphorylation	PHSPFRRSLSLEVGG CCCHHCCCEEEEECC	20.32	19060867
956	Phosphorylation	SPFRRSLSLEVGGEP CHHCCCEEEEECCEE	24.59	21082442
995	Phosphorylation	PYLPRQQSDGSLVRS CCCCCCCCCCCEEEC	35.28	22324799
998	Phosphorylation	PRQQSDGSLVRSQRP CCCCCCCCEEECCCC	28.78	22324799
1089	Methylation	SSPAPVWRNSLGAPS CCCCCCHHHCCCCCC	24.08	54541517
1089	Dimethylation	SSPAPVWRNSLGAPS CCCCCCHHHCCCCCC	24.08	-
1091	Phosphorylation	PAPVWRNSLGAPSAL CCCCHHHCCCCCCHH	21.43	22817900
1144	Phosphorylation	SYGMLGQSPPLHRSP CCCCCCCCCCCCCCC	27.04	22817900
1162	Phosphorylation	LSYPPPPSCFPPEHL HCCCCCCCCCCHHHH	33.88	29514104
1188	Phosphorylation	PTRPEPLYVNLALGP CCCCCCEEEEEEECC	9.67	22817900
1207	Phosphorylation	PASSSSSSPPAHPRS CCCCCCCCCCCCCCC	36.53	29899451
1263	Methylation	PAPPSYGRGGEVRGS CCCCCCCCCCCCCCE	41.53	24129315
1268	Methylation	YGRGGEVRGSLYRNG CCCCCCCCCEEECCC	25.36	54541521
1268	Dimethylation	YGRGGEVRGSLYRNG CCCCCCCCCEEECCC	25.36	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RHG33_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RHG33_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RHG33_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDC42_MOUSE	Cdc42	physical	12773384
CRK_MOUSE	Crk	physical	12773384
RHOJ_MOUSE	Rhoj	physical	12773384

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations.";
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.;
Mol. Cell. Proteomics 5:914-922(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-594, AND MASSSPECTROMETRY.
PubMed: 16452087

"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1188, AND MASSSPECTROMETRY.
PubMed: 18034455