dbPTM

MARK3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MARK3_MOUSE
UniProt AC	Q03141
Protein Name	MAP/microtubule affinity-regulating kinase 3
Gene Name	Mark3
Organism	Mus musculus (Mouse).
Sequence Length	753
Subcellular Localization	Cell membrane Peripheral membrane protein . Cell projection, dendrite . Cytoplasm .
Protein Description	Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAPT/TAU, MAP2 and MAP4. Phosphorylates CDC25C. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1..
Protein Sequence	MSTRTPLPTVNERDTENHISHGDGRQEVTSRTGRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPVKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSAELDASDSSSSSNLSLAKVRPNSDLSNSTGQSPHHKGQRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGIPSRKSSSSAVGGKGIAPASPMLGNAGNPNKADIPERKKSPAVPSSNTASGGMTRRNTYVCSERCAADRHSVIQNGKENSAIPDERTPVASTHSISSATTPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSSEQKDENREAKPRSLRFTWSMKTTSSMDPSDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSTRTPLPT ------CCCCCCCCC	26.96	22324799
3	Phosphorylation	-----MSTRTPLPTV -----CCCCCCCCCC	36.94	22324799
42	Phosphorylation	SGARCRNSIASCADE CCCCHHHCHHHHCCC	10.53	25521595
45	Phosphorylation	RCRNSIASCADEQPH CHHHCHHHHCCCCCC	14.25	21659605
61	Phosphorylation	GNYRLLKTIGKGNFA CCEEHHHHHCCCCCH	34.63	22817900
71	Succinylation	KGNFAKVKLARHILT CCCCHHHHHHHHHHC	35.40	24315375
78	Phosphorylation	KLARHILTGREVAIK HHHHHHHCCCHHHEE	33.32	28059163
164	Phosphorylation	AKFRQIVSAVQYCHQ HHHHHHHHHHHHHHH	25.09	-
168	Phosphorylation	QIVSAVQYCHQKRIV HHHHHHHHHHHHCCC	5.82	26487105
211	Phosphorylation	TVGSKLDTFCGSPPY ECCCCHHHCCCCCCC	31.12	25521595
215	Phosphorylation	KLDTFCGSPPYAAPE CHHHCCCCCCCCCHH	24.71	22942356
218	Phosphorylation	TFCGSPPYAAPELFQ HCCCCCCCCCHHHHC	20.84	25159016
368	Phosphorylation	YLLLGRKSAELDASD HHHHCCCCCCCCCCC	26.14	25521595
374	Phosphorylation	KSAELDASDSSSSSN CCCCCCCCCCCCCCC	37.38	27742792
376	Phosphorylation	AELDASDSSSSSNLS CCCCCCCCCCCCCCE	29.62	25521595
377	Phosphorylation	ELDASDSSSSSNLSL CCCCCCCCCCCCCEE	38.95	25521595
378	Phosphorylation	LDASDSSSSSNLSLA CCCCCCCCCCCCEEE	41.56	25521595
379	Phosphorylation	DASDSSSSSNLSLAK CCCCCCCCCCCEEEE	25.78	27742792
380	Phosphorylation	ASDSSSSSNLSLAKV CCCCCCCCCCEEEEE	43.68	25521595
383	Phosphorylation	SSSSSNLSLAKVRPN CCCCCCCEEEEECCC	30.45	25521595
391	Phosphorylation	LAKVRPNSDLSNSTG EEEECCCCCCCCCCC	42.48	26824392
394	Phosphorylation	VRPNSDLSNSTGQSP ECCCCCCCCCCCCCC	33.45	25619855
396	Phosphorylation	PNSDLSNSTGQSPHH CCCCCCCCCCCCCCC	30.45	25619855
397	Phosphorylation	NSDLSNSTGQSPHHK CCCCCCCCCCCCCCC	43.41	25619855
400	Phosphorylation	LSNSTGQSPHHKGQR CCCCCCCCCCCCCCC	27.78	21930439
410	Phosphorylation	HKGQRSVSSSQKQRR CCCCCCCCHHHHHHH	26.06	24719451
411	Phosphorylation	KGQRSVSSSQKQRRY CCCCCCCHHHHHHHH	34.33	23375375
412	Phosphorylation	GQRSVSSSQKQRRYS CCCCCCHHHHHHHHC	33.61	23375375
418	Phosphorylation	SSQKQRRYSDHAGPA HHHHHHHHCCCCCCC	22.19	27742792
419	Phosphorylation	SQKQRRYSDHAGPAI HHHHHHHCCCCCCCC	22.55	21930439
428	Phosphorylation	HAGPAIPSVVAYPKR CCCCCCCCEEECCCC	24.10	28833060
432	Phosphorylation	AIPSVVAYPKRSQTS CCCCEEECCCCCCCC	9.55	28833060
436	Phosphorylation	VVAYPKRSQTSTADS EEECCCCCCCCCCCH	43.89	25521595
438	Phosphorylation	AYPKRSQTSTADSDL ECCCCCCCCCCCHHH	29.32	27841257
439	Phosphorylation	YPKRSQTSTADSDLK CCCCCCCCCCCHHHC	17.60	29550500
440	Phosphorylation	PKRSQTSTADSDLKE CCCCCCCCCCHHHCC	37.56	29550500
443	Phosphorylation	SQTSTADSDLKEDGI CCCCCCCHHHCCCCC	42.24	29899451
452	Phosphorylation	LKEDGIPSRKSSSSA HCCCCCCCCCCCCCC	50.88	23375375
455	Phosphorylation	DGIPSRKSSSSAVGG CCCCCCCCCCCCCCC	34.05	23375375
456	Phosphorylation	GIPSRKSSSSAVGGK CCCCCCCCCCCCCCC	31.20	23375375
469	Phosphorylation	GKGIAPASPMLGNAG CCCCCCCCCCCCCCC	15.13	25521595
489	Phosphorylation	DIPERKKSPAVPSSN CCCHHCCCCCCCCCC	22.56	25619855
494	Phosphorylation	KKSPAVPSSNTASGG CCCCCCCCCCCCCCC	29.62	25266776
499	Phosphorylation	VPSSNTASGGMTRRN CCCCCCCCCCCCCCC	33.56	29899451
503	Phosphorylation	NTASGGMTRRNTYVC CCCCCCCCCCCEEEC	29.74	-
507	Phosphorylation	GGMTRRNTYVCSERC CCCCCCCEEECCCCC	18.60	22322096
508	Phosphorylation	GMTRRNTYVCSERCA CCCCCCEEECCCCCC	11.74	22322096
520	Phosphorylation	RCAADRHSVIQNGKE CCCCCCCHHHHCCCC	23.08	-
529	Phosphorylation	IQNGKENSAIPDERT HHCCCCCCCCCCCCC	28.77	26060331
536	Phosphorylation	SAIPDERTPVASTHS CCCCCCCCCCCCCCC	21.77	25619855
540	Phosphorylation	DERTPVASTHSISSA CCCCCCCCCCCCCCC	27.21	25521595
541	Phosphorylation	ERTPVASTHSISSAT CCCCCCCCCCCCCCC	15.20	26824392
543	Phosphorylation	TPVASTHSISSATTP CCCCCCCCCCCCCCC	25.01	25521595
545	Phosphorylation	VASTHSISSATTPDR CCCCCCCCCCCCCCC	19.55	21082442
546	Phosphorylation	ASTHSISSATTPDRI CCCCCCCCCCCCCCE	28.15	20469934
548	Phosphorylation	THSISSATTPDRIRF CCCCCCCCCCCCEEC	40.59	25619855
549	Phosphorylation	HSISSATTPDRIRFP CCCCCCCCCCCEECC	23.94	22942356
561	Phosphorylation	RFPRGTASRSTFHGQ ECCCCCCCCCCCCCC	26.97	25338131
563	Phosphorylation	PRGTASRSTFHGQPR CCCCCCCCCCCCCCC	32.69	25266776
564	Phosphorylation	RGTASRSTFHGQPRE CCCCCCCCCCCCCCC	20.67	24899341
574	Phosphorylation	GQPRERRTATYNGPP CCCCCCCCCEECCCC	29.58	25619855
576	Phosphorylation	PRERRTATYNGPPAS CCCCCCCEECCCCCC	19.53	25619855
577	Phosphorylation	RERRTATYNGPPASP CCCCCCEECCCCCCC	18.69	25619855
583	Phosphorylation	TYNGPPASPSLSHEA EECCCCCCCCCCCCC	22.31	27087446
585	Phosphorylation	NGPPASPSLSHEATP CCCCCCCCCCCCCCC	39.75	25619855
587	Phosphorylation	PPASPSLSHEATPLS CCCCCCCCCCCCCHH	24.50	25619855
591	Phosphorylation	PSLSHEATPLSQTRS CCCCCCCCCHHHCCC	23.06	25619855
594	Phosphorylation	SHEATPLSQTRSRGS CCCCCCHHHCCCCCC	30.61	25619855
596	Phosphorylation	EATPLSQTRSRGSTN CCCCHHHCCCCCCCC	27.51	25619855
598	Phosphorylation	TPLSQTRSRGSTNLF CCHHHCCCCCCCCHH	44.36	24899341
599	Methylation	PLSQTRSRGSTNLFS CHHHCCCCCCCCHHH	39.53	58858439
601 (in isoform 2)	Phosphorylation	-	17.01	27566939
601	Phosphorylation	SQTRSRGSTNLFSKL HHCCCCCCCCHHHHH	17.01	26824392
602 (in isoform 2)	Phosphorylation	-	38.47	25266776
602	Phosphorylation	QTRSRGSTNLFSKLT HCCCCCCCCHHHHHH	38.47	25266776
615 (in isoform 2)	Phosphorylation	-	37.66	25266776
618	Phosphorylation	KLTRRNMSFRFIKRL HHHHHCCCHHHHHCC	19.47	29550500
619 (in isoform 2)	Phosphorylation	-	5.27	25266776
620 (in isoform 2)	Phosphorylation	-	25.69	25266776
629	Phosphorylation	IKRLPTEYERNGRYE HHCCCCHHHHCCCCC	23.75	29514104
638	Phosphorylation	RNGRYEGSSRNVSSE HCCCCCCCCCCCCHH	17.74	29550500
639	Phosphorylation	NGRYEGSSRNVSSEQ CCCCCCCCCCCCHHH	38.44	29550500
643	Phosphorylation	EGSSRNVSSEQKDEN CCCCCCCCHHHCCCC	31.54	29550500
644	Phosphorylation	GSSRNVSSEQKDENR CCCCCCCHHHCCCCC	39.50	29550500
657	Phosphorylation	NREAKPRSLRFTWSM CCCCCCCCEEEEEEC	32.21	-
663	Phosphorylation	RSLRFTWSMKTTSSM CCEEEEEECCCCCCC	13.82	22006019
667	Phosphorylation	FTWSMKTTSSMDPSD EEEECCCCCCCCHHH	17.18	28576409
681	Ubiquitination	DMMREIRKVLDANNC HHHHHHHHHHHHCCC	53.46	22790023
724	Phosphorylation	VCKLPRLSLNGVRFK HHCCCCEEECCEEEE	22.52	21183079
741	Ubiquitination	SGTSIAFKNIASKIA CCCHHHHHHHHHHHH	38.12	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
211	T	Phosphorylation	Kinase	LKB1	Q9WTK7	Uniprot
564	T	Phosphorylation	Kinase	PRKCZ	Q02956	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
211	T	Phosphorylation	-
Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.
564	T	Phosphorylation	-
Phosphorylation at Thr-564 by PRKCZ/aPKC inhibits the kinase activity (By similarity).

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MARK3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
1433Z_MOUSE	Ywhaz	physical	16959763
1433B_MOUSE	Ywhab	physical	16959763
1433G_MOUSE	Ywhag	physical	16959763
1433F_MOUSE	Ywhah	physical	16959763

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MARK3_MOUSE

Related Literatures of Post-Translational Modification

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