AHI1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AHI1_MOUSE
• UniProt AC: Q8K3E5
• Protein Name: Jouberin
• Gene Name: Ahi1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1047
• Subcellular Localization: Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cell junction, adherens junction .
• Protein Description: Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. [PubMed: 19625297 Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes]
• Protein Sequence: MEPETPEKVDSAQEKVRGKTPTADDSDDSREKTGIEEKGELTDAYQLQVAEEMAKEIKKKIRKKLKEQLTYFPPDTLLHDDKLASEKRKKKKKKVPVPTKPESSPSDVCDSAVEGEQKKEGTPEDSQHMEGICSREQDVDATVPENAKPKPKKTKKKTKAVSNDNEDTNGDGVHEITSRDSPVHPKCLLDDDLVMGVYIHRTDRLKSDFMISHPMVKIHVVDEHTGQYVKKDDSERPVSSYYEKDNVDYILPIMTQPYDFKKLKSRLPEWEEQVIFNENFPYLLREFEECPKVILFFEILDFLSMDEIKNNSEVQNQECGFRKIAWAFLKLLGANGNANINSKLRLQLYYPPTKPRSQLNVVEVFEWWSKCPRNRYPSTLYVTVRGLKVPDCIKPSYRSMMALQEERGTPVYCERHRETSSVDTEPGLEDSKEEVKWKRLPGQACRIPNKHLFSLNAGERGCFCLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDLDWSKDDRYLVTSSSDGTARVWKNEINSTSTFRVLPHPSFVYTAKFHPATRELVVTGCYDSMIRIWKIDAREDAAILVRQLDVHKSFVNSICFDDEGHHMYSGDCIGVIVVWDTYVKVNDVQTSVRHWTINKEIKETEFRGVPISYLEVHPNGKRLLIHTKDSTLRIMDLRILAARKFVGAANYREKIHSTLTPCGTLLFSGSEDGIVYVWNPETGEQVAMYSDLPFKSTIRDISYHPLENMVAFCAFGQSEPILLYIYDFQVAQQEAEMLKRYSGTLPLPGIHQSEDALCTCPKLPQQGSFQIDEFVNTENSSSRKIQLVKQRLETVTEVIRSCAAKVNKNLSMTSPPPGPAKKPRVKQSFVLTTDEIIHQFGLPQTAFISIERGPFVRHVDPPPMVVALYDYTASRSDELTIHRGDIIRVYFKDNEDWWYGSVRKGQEGFFPANHVASETLYRDSPPKVKERSPPLTPKEKTKPEKPLASQKQSLSKGRPLDPRLGPQPVGHSEKGKDQNVEDRGHKVDMETKKSEPVVRKVTLIE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MEPETPEKVDSA ---CCCCCHHHHHHH	47.68	4099491
11	Phosphorylation	ETPEKVDSAQEKVRG CCHHHHHHHHHHHCC	34.53	31437733
20	Phosphorylation	QEKVRGKTPTADDSD HHHHCCCCCCCCCCC	28.79	25521595
22	Phosphorylation	KVRGKTPTADDSDDS HHCCCCCCCCCCCCH	48.20	29899451
26	Phosphorylation	KTPTADDSDDSREKT CCCCCCCCCCHHHHH	43.81	25521595
29	Phosphorylation	TADDSDDSREKTGIE CCCCCCCHHHHHCCC	47.53	25521595
76	Phosphorylation	LTYFPPDTLLHDDKL HHCCCCCCCCCCHHH	36.67	29899451
85	Phosphorylation	LHDDKLASEKRKKKK CCCHHHHHHHHHHCC	54.83	27149854
104	Phosphorylation	VPTKPESSPSDVCDS CCCCCCCCCCCCCHH	27.11	25521595
106	Phosphorylation	TKPESSPSDVCDSAV CCCCCCCCCCCHHHH	44.62	29899451
111	Phosphorylation	SPSDVCDSAVEGEQK CCCCCCHHHHCCCCC	29.14	29899451
122	Phosphorylation	GEQKKEGTPEDSQHM CCCCCCCCCCCHHHH	25.29	7655653
162	Phosphorylation	KKKTKAVSNDNEDTN CCCCCCCCCCCCCCC	43.24	25367039
168	Phosphorylation	VSNDNEDTNGDGVHE CCCCCCCCCCCCCEE	34.62	25367039
177	Phosphorylation	GDGVHEITSRDSPVH CCCCEECCCCCCCCC	18.09	20415495
178	Phosphorylation	DGVHEITSRDSPVHP CCCEECCCCCCCCCC	39.49	25367039
181	Phosphorylation	HEITSRDSPVHPKCL EECCCCCCCCCCCCC	27.93	21930439
241	Phosphorylation	SERPVSSYYEKDNVD CCCCCCCCEECCCCC	14.24	29514104
323	Ubiquitination	NQECGFRKIAWAFLK CCCCHHHHHHHHHHH	34.22	-
343	Ubiquitination	GNANINSKLRLQLYY CCCCCCCCEEEEEEC	32.89	-
354	Ubiquitination	QLYYPPTKPRSQLNV EEECCCCCCHHHCCE	44.18	-
420	Phosphorylation	CERHRETSSVDTEPG CHHCCCCCCCCCCCC	24.50	29899451
421	Phosphorylation	ERHRETSSVDTEPGL HHCCCCCCCCCCCCC	31.28	25521595
783	Phosphorylation	EAEMLKRYSGTLPLP HHHHHHHHCCCCCCC	15.18	29899451
810	Phosphorylation	PKLPQQGSFQIDEFV CCCCCCCCEECEEEE	15.05	25521595
836	Phosphorylation	LVKQRLETVTEVIRS HHHHHHHHHHHHHHH	37.00	26745281
838	Phosphorylation	KQRLETVTEVIRSCA HHHHHHHHHHHHHHH	31.77	26745281
843	Phosphorylation	TVTEVIRSCAAKVNK HHHHHHHHHHHHCCC	9.29	26745281
853	Phosphorylation	AKVNKNLSMTSPPPG HHCCCCCCCCCCCCC	29.43	25777480
855	Phosphorylation	VNKNLSMTSPPPGPA CCCCCCCCCCCCCCC	34.40	25521595
856	Phosphorylation	NKNLSMTSPPPGPAK CCCCCCCCCCCCCCC	27.11	25521595
946	Ubiquitination	WWYGSVRKGQEGFFP EEEEECCCCCCCEEC	63.89	-
966	Phosphorylation	SETLYRDSPPKVKER CHHHCCCCCCCCCCC	33.82	25338131
974	Phosphorylation	PPKVKERSPPLTPKE CCCCCCCCCCCCCHH	31.77	25521595
978	Phosphorylation	KERSPPLTPKEKTKP CCCCCCCCCHHCCCC	37.78	25521595
995	Phosphorylation	PLASQKQSLSKGRPL CCHHHHHCHHCCCCC	41.46	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AHI1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AHI1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AHI1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TCPQ_MOUSE	Cct8	physical	21565611
TECT1_MOUSE	Tctn1	physical	21565611
K1C16_MOUSE	Krt16	physical	21565611
TBA1B_MOUSE	Tuba1b	physical	21565611
GRP75_MOUSE	Hspa9	physical	21565611
TBB5_MOUSE	Tubb5	physical	21565611
K2C73_MOUSE	Krt73	physical	21565611
K1C42_MOUSE	Krt42	physical	21565611
MKS1_MOUSE	Mks1	physical	21565611
K2C1_MOUSE	Krt1	physical	21565611
K2C1B_MOUSE	Krt77	physical	21565611
K1C14_MOUSE	Krt14	physical	21565611
K1C10_MOUSE	Krt10	physical	21565611
K22O_MOUSE	Krt76	physical	21565611
GRP78_MOUSE	Hspa5	physical	21565611
K1C15_MOUSE	Krt15	physical	21565611
K22E_MOUSE	Krt2	physical	21565611
ACTB_MOUSE	Actb	physical	21565611
C2D2A_MOUSE	Cc2d2a	physical	21565611
HSP7C_MOUSE	Hspa8	physical	21565611
RS27A_MOUSE	Rps27a	physical	21565611
PLAK_MOUSE	Jup	physical	21565611
K2C5_MOUSE	Krt5	physical	21565611
HS90B_MOUSE	Hsp90ab1	physical	21565611
MYO15_MOUSE	Myo15	physical	21565611
HS90A_MOUSE	Hsp90aa1	physical	21565611
FHL2_MOUSE	Fhl2	physical	21565611

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.