| UniProt ID | MKS1_MOUSE | |
|---|---|---|
| UniProt AC | Q5SW45 | |
| Protein Name | Meckel syndrome type 1 protein homolog | |
| Gene Name | Mks1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 561 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localizes at the transition zone, a region between the basal body and the ciliary axoneme. | |
| Protein Description | Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology.. | |
| Protein Sequence | MAEAVWSTDTGEAVYRSRDPVRNLRLRVHLQRITSSNFLHYQPAAQMGKDLIDLATFRPPQAASGHRPDEEEEEEVVIGWQEKLFSQFEVDLYQNESACQSPLDHQYRQEILKLENSGGRKNRRIFTYTDSDRYTDLEEYCQKITTSASEVPSFLAERMANVRRRRQDRRGVEGSKLKSRIVTWEPSEDFIKNNHAINTPLQTMYIMADLGPYGKLGYKVHEHVLCILKVDSNGVITVKPDFTGIKGPYRIETEGEKQEHTSAWKYTIDNVSSLAQPEEEEREQRVFKDLYGRHKEYLSSLVGTDFEMIAPGALRLFVNGEVVSAQGYEYDNLYVHFFVELPAANWSSPPFQQLSGVTQACATKSLGMDKVAYFSFPFTFEAFFLHEDESAESLPEWPVLYCKVLSLDFWQRYRVEGYGAVVLPATPGSHTLTVSTWRPMELGLVAELRRFFIGGSLELEDPSYVRIPGTFKGERLSRFGFRTETTGTVTFRLHCLQQSRAFMESNSLQKQMRSVLDRLEGFSQQSSTHNVLEAFRRARRRMQEARESLPQDLVSPTGTLT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 145 | Phosphorylation | EEYCQKITTSASEVP HHHHHHHCCCHHHCH | 23.02 | 21454597 | |
| 149 | Phosphorylation | QKITTSASEVPSFLA HHHCCCHHHCHHHHH | 38.60 | 21454597 | |
| 464 | Phosphorylation | LELEDPSYVRIPGTF EEECCCCCEECCCCC | 10.11 | - | |
| 483 | Phosphorylation | LSRFGFRTETTGTVT EECEEEEECCCCEEE | 35.11 | 29895711 | |
| 485 | Phosphorylation | RFGFRTETTGTVTFR CEEEEECCCCEEEEE | 29.88 | 29895711 | |
| 486 | Phosphorylation | FGFRTETTGTVTFRL EEEEECCCCEEEEEE | 25.32 | 29895711 | |
| 490 | Phosphorylation | TETTGTVTFRLHCLQ ECCCCEEEEEEHHHH | 11.68 | 29895711 | |
| 559 | Phosphorylation | DLVSPTGTLT----- CCCCCCCCCC----- | 29.69 | 25338131 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MKS1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MKS1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MKS1_MOUSE !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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