TECT2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TECT2_MOUSE
• UniProt AC: Q2MV57
• Protein Name: Tectonic-2
• Gene Name: Tctn2
• Organism: Mus musculus (Mouse).
• Sequence Length: 700
• Subcellular Localization: Membrane ; Single-pass type I membrane protein . Cytoplasm, cytoskeleton, cilium basal body . Localizes at the transition zone, a region between the basal body and the ciliary axoneme.
• Protein Description: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction..
• Protein Sequence: MGSLSPLSLLWGLLLLQGVLRPLRGDPVFIPPFIRMSSPEVRATLVGGSEDVAVSLSLLQVEEGVLPVPTCGGRRNETVDWNVTVSPRESTLEVTIRWKRGLDWCSADETASFSEPPCVLQMLLVSASHNASCLAHLLIQVEIYPNTSVTHNASENMTVIPNQVYQPLGPCPCDLTAKACDIQCCCDQDCQPEVRELFAQSCFSGVFGGHVSPPSHHHCAVSTTHQTPDWFPLLCVQSPPSTSPFLGHFYHGATSPRHSPGFEAHLHFDLRDFADASYKQGDPIMTTEGYFTIPQVSLAGQCLQDAPVAFLRNFDSVCTMDLEVHQGRDEIVLENMKIRTTGGPVTPTVTYEEAIDLDKFITSPDTVLSVGSAPRNVNVEEHYVFRWQNNSISGLDITVIRAEISAQQRGMMTQRFTVKFLSHHSGGEKEFSGNPGYQLGKPVRALHTAGMNVSTLHLWQPAGRGLCTAAALRPILFGENAFSGCLLEVGIKENCTQLRENVLQRLDLLTQATHVARRGNSDYSDLSDGWLEIIRAEAPDTGADLPLSSVNGVCPEVPARLSIRILTAEAGSVEGVAQREILAVETRFSTVTWQYQCGLTCEDKADLLPLSASVEFINVPAQMPHPPTRFQINFTEYDCTRNELCWPQLLYPLTQYYQGEPQSQCVAKGLMLLSLLMLAILLRHPWVRMCKARDSAAIYH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	N-linked_Glycosylation	PTCGGRRNETVDWNV CCCCCCCCCEECEEE	48.18	-
82	N-linked_Glycosylation	RNETVDWNVTVSPRE CCCEECEEEEECCCC	18.34	-
146	N-linked_Glycosylation	IQVEIYPNTSVTHNA HEEEECCCCCCCCCC	28.19	-
156	N-linked_Glycosylation	VTHNASENMTVIPNQ CCCCCCCCEEECCCC	29.00	-
340	Phosphorylation	LENMKIRTTGGPVTP EECCEEEECCCCCCC	33.01	25777480
341	Phosphorylation	ENMKIRTTGGPVTPT ECCEEEECCCCCCCC	30.23	25777480
346	Phosphorylation	RTTGGPVTPTVTYEE EECCCCCCCCEEHHH	19.17	25777480
348	Phosphorylation	TGGPVTPTVTYEEAI CCCCCCCCEEHHHCC	19.00	25777480
350	Phosphorylation	GPVTPTVTYEEAIDL CCCCCCEEHHHCCCH	27.91	25777480
351	Phosphorylation	PVTPTVTYEEAIDLD CCCCCEEHHHCCCHH	13.87	25777480
389	N-linked_Glycosylation	HYVFRWQNNSISGLD EEEEEECCCCCCCCE	36.94	19349973
521	Phosphorylation	HVARRGNSDYSDLSD HHHHCCCCCCHHCCC	40.52	25367039
523	Phosphorylation	ARRGNSDYSDLSDGW HHCCCCCCHHCCCCE	12.14	25367039
524	Phosphorylation	RRGNSDYSDLSDGWL HCCCCCCHHCCCCEE	36.75	25367039
527	Phosphorylation	NSDYSDLSDGWLEII CCCCHHCCCCEEEEE	38.78	25367039
541	Phosphorylation	IRAEAPDTGADLPLS EEEECCCCCCCCCHH	32.96	25367039
548	Phosphorylation	TGADLPLSSVNGVCP CCCCCCHHHCCCCCC	30.24	25367039
549	Phosphorylation	GADLPLSSVNGVCPE CCCCCHHHCCCCCCC	27.56	25367039

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TECT2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TECT2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TECT2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MKS1_MOUSE	Mks1	physical	21565611

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-389, AND MASSSPECTROMETRY.
PubMed: 19349973