TECT1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TECT1_MOUSE
• UniProt AC: Q8BZ64
• Protein Name: Tectonic-1
• Gene Name: Tctn1
• Organism: Mus musculus (Mouse).
• Sequence Length: 593
• Subcellular Localization: Cytoplasm, cytoskeleton, cilium basal body. Secreted. Localizes at the transition zone, a region between the basal body and the ciliary axoneme. Despite the presence of a signal sequence, the full-length protein might not be secreted (PubMed:16357211
• Protein Description: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23..
• Protein Sequence: MGSRGLPPLLLVLLNCYTSSSTQVIAIPAAATPAVTKEDLNSTKATPTTLQPSLSPRTPGTPRAPERSGPRPTPVTDVAALCVCDLLPAQCDVNCCCDPDCSPADFSIFSACSVPVVTGDRQFCSQKAAFYSMNLTADPPHRDFKLIDQINPSVFCIHISNYKPALSFANPEVPDENNFDRLMQTSGGFTLSAESAVPSTAASDGPQPTKYEYGAPLQTAGASSGSFLKLPSPLTSSLCADQNPAAFLVSQAFECSRRVDIEQCEGMEALSMAHYSSPAILRVPNSMTQVSIKIQSVMYRSLNHTLTQLEGHGVLRPSLVSTGQDRLCSNVVLQVKYSLLYTATGQIHEAGLSLVLGTLSSAVSLLQQKFEIHFIQHGTKPVPLSGNPGYRVGLPLAAGFQPQKGSGIIQTTNRQGQFTILRSTSQQDCLASEGLRTPVLFGYNVQSGCQLRLTGTIPCGLLAQKVQDLLRGQAFPDYVAAFGNSRAQDVQDWVPVHFVTYSSNMKGSCQLPVALAIEVKWTKYGSLLNPQARIVNVTAQLVSVPEPLPGPERTVVISTAVTFVDVSAPAEAGFRAPPTINARLPFSFFFPFV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	N-linked_Glycosylation	AVTKEDLNSTKATPT CCCHHHHCCCCCCCC	61.01	-
49	Phosphorylation	STKATPTTLQPSLSP CCCCCCCCCCCCCCC	25.30	22871156
53	Phosphorylation	TPTTLQPSLSPRTPG CCCCCCCCCCCCCCC	28.63	26026062
55	Phosphorylation	TTLQPSLSPRTPGTP CCCCCCCCCCCCCCC	19.37	26026062
61	Phosphorylation	LSPRTPGTPRAPERS CCCCCCCCCCCCCCC	15.71	22871156
303	N-linked_Glycosylation	SVMYRSLNHTLTQLE HHHHHHHCCCCCEEE	27.61	-
454	Phosphorylation	SGCQLRLTGTIPCGL CCCEEEECCCCCCHH	26.33	26239621
456	Phosphorylation	CQLRLTGTIPCGLLA CEEEECCCCCCHHHH	19.26	26239621
486	Methylation	VAAFGNSRAQDVQDW HHHHCCCCCCHHHHC	40.02	24129315
536	N-linked_Glycosylation	NPQARIVNVTAQLVS CCCCEEEEEEEEEEE	24.05	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TECT1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TECT1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TECT1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TECT1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.