C2D2A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: C2D2A_MOUSE
• UniProt AC: Q8CFW7
• Protein Name: Coiled-coil and C2 domain-containing protein 2A
• Gene Name: Cc2d2a
• Organism: Mus musculus (Mouse).
• Sequence Length: 1633
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton, cilium basal body . Localizes at the transition zone, a region between the basal body and the ciliary axoneme.
• Protein Description: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling..
• Protein Sequence: MNTNDEKMKIISEDFTGDGVDTEAGRRKKNSKVRRQQRKKKPPASPPEEMVSDKFQDGGQQEVVEEEPETNLLSLTARRGPRSLPPIPSASRTGFAEFSMRERMREKLQAARSKAESALLRDVPTPRPRRLRSPSREKETETEFGTEPSTEVQDTQKEDDTKSYSRIKFRDSVRKIKSKPQLPPGFPSAEEAYNFFTFNFDPEPEESEEKSPVKGGERAHHEDQEGEEGTQAQERAKKTEEEELLNGKDAEDFLLGLDPTAHDFVAVRAAEYKSARIQLQKEKEILFTPSRLTVPTYKKLPENIQPRFLEDEGLYIGARPEVARTNENIMENRLLIQEPGSKWFGDDGRILALPSPIKPFPSRPSLTTREQSPKAGLETLYKKAEKYVHSRQHMIGSGDPPGNFQLDIDISGLIFTHHPCFSREHVLASKLAQLYDQYLARQQRNKTKFLTDKLQALRKAVQTSLNPEKPHQSLDTTQKTINEYKSEIRQTRKLRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKVDPKLDEDAYEAEIQAEIHELLEEHMEEYATKMEEYRTSHQQWKAWRKAQRAKKKKKKQTTEEHLEEEEAEESFPEEEVTKPIPPEPTDPAVIEQQVRERAAHSRRRPGEPTLIPELSLAGNVTPNDQCPRVEVSRREDVRRRSVYLKVVFNSKEVSRTVSRPLGADFRVHFGQIFNLQIFNWPESLMLQVYETIGHSGTTLLAEVFLPIPETTLVTGRAPIEEVEFSSNQHVTLDHEGVGSGVPFSFEADGSNQLTLMTSGKVSHSVAWAVGENGIPLIPPLSQQNIGFRSALRRADAISSIGTSGLTDMKKLAKWAAESKLDPNDPNHAPLMQLISVATSGESYVPDFFRLEQLQQEFNFVSEEELNRSKRFRLLHLRSQEVPEFRNYKQIPAYDREIMEKVFQDYEKRLRDRNVIETKDHLDMHRATVAKYLQQVREAVVNRFLTAKHHFLLTDLVVEEEVPNISSEGSGILGLSLFKLAEQKRPLRPRRKGRKKVTAQNLSDGDIKLLVNIIRAYDIPVRKPVVSKFQQPSRSSRTFSEKQTASPSTHSPLHNADYPLGQVLVRPFVEVSFQRTICHTTTAEGPNPSWNEELELPFRAPNGDYSTASLQSVKDDVYINIFDEVLYDILEDDRERGSGIHTRIERHWLGCVKIPFSTIYFQARIDGTFKIDIPPVLLGYSKERNIIMERAFDSARSLSEGSYITLFITIEPQLVPGEPMREKMSDMLKKFDTQEDEKLLQATEKFQAECALKFPQRQCLTTVTDMTGKTVFITRYLKPLNPPQELLHVYPNNPQATAELVARYVSLIPFLPDSVSFAGVCDLWSTSDQFLDLLAGDEEEHAVLLCNYFLFLGKKAWLVMGSAIPEGPTAYVLTWEKNYYLIWNPCSGHCYGQFDAFCPLKSVGCLIGPDNIWFNIQHHDSPLRINFDVTKPKLWKSFFSRSLPYPGLSSVQPEELIYQHTDKAVAAELQDRIEKILKEKIMDWRPRHLTRWNRYCTSTLRHFLPLLERSQGEDIEDDHRAELLKQLGDYRFSGFPLHMPYSEVKPLVEAVYSTGVHNIDLPNVEFALAVYIHPYPKNVLSVWIYVASLVRNR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
99	Phosphorylation	RTGFAEFSMRERMRE CCCCCCCHHHHHHHH	14.40	29514104
107	Malonylation	MRERMREKLQAARSK HHHHHHHHHHHHHHH	35.22	26320211
133	Phosphorylation	PRPRRLRSPSREKET CCCCCCCCCCCCCCC	31.64	23737553
135	Phosphorylation	PRRLRSPSREKETET CCCCCCCCCCCCCCC	55.08	23737553
238	Acetylation	QAQERAKKTEEEELL HHHHHHHHHHHHHHH	61.25	22902405
843	Phosphorylation	DAISSIGTSGLTDMK HHHHHCCCCCCHHHH	20.25	29899451
844	Phosphorylation	AISSIGTSGLTDMKK HHHHCCCCCCHHHHH	26.96	-
847	Phosphorylation	SIGTSGLTDMKKLAK HCCCCCCHHHHHHHH	37.26	-
1073	Phosphorylation	VSKFQQPSRSSRTFS CCCCCCCCCCCCCCC	40.22	25338131
1075	Phosphorylation	KFQQPSRSSRTFSEK CCCCCCCCCCCCCCC	28.63	25338131
1273	Phosphorylation	DMLKKFDTQEDEKLL HHHHHCCCHHHHHHH	36.67	22982522
1470	Phosphorylation	LRINFDVTKPKLWKS EEEEEEECCHHHHHH	43.40	-
1515	Malonylation	ELQDRIEKILKEKIM HHHHHHHHHHHHHHH	51.47	26073543

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of C2D2A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of C2D2A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of C2D2A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of C2D2A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.