FHL2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FHL2_MOUSE
• UniProt AC: O70433
• Protein Name: Four and a half LIM domains protein 2
• Gene Name: Fhl2
• Organism: Mus musculus (Mouse).
• Sequence Length: 279
• Subcellular Localization: Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, Z line .
• Protein Description: May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation (By similarity). Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes. [PubMed: 22851699]
• Protein Sequence: MTERFDCHHCNESLYGKKYILKEENPHCVACFEELYANTCEECGTPIGCDCKDLSYKDRHWHEGCFHCSRCGSSLVDKPFAAKEEQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFTCQRCQQPIGTKSFIPKENQNFCVPCYEKQYALQCVQCKKPITTGGVTYREQPWHKECFVCTACKKQLSGQRFTARDEFPYCLTCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDCGKDI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
71	S-nitrosylation	GCFHCSRCGSSLVDK CCCCCCCCCCCCCCC	3.40	21278135
71	S-nitrosocysteine	GCFHCSRCGSSLVDK CCCCCCCCCCCCCCC	3.40	-
90	Phosphorylation	KEEQLLCTDCYSNEY CHHHEEECCCCCCCC	29.13	-
106	Ubiquitination	SKCQECKKTIMPGTR HHHHHHHCCCCCCCC	55.75	22790023
107	Phosphorylation	KCQECKKTIMPGTRK HHHHHHCCCCCCCCC	14.17	-
117	Phosphorylation	PGTRKMEYKGSSWHE CCCCCCEECCCCHHC	19.70	-
132	S-nitrosocysteine	TCFTCQRCQQPIGTK EECCCCCCCCCCCCC	1.49	-
132	S-nitrosylation	TCFTCQRCQQPIGTK EECCCCCCCCCCCCC	1.49	21278135
154	Phosphorylation	QNFCVPCYEKQYALQ CCCEEECCCCEEEEE	21.79	22499769
158	Phosphorylation	VPCYEKQYALQCVQC EECCCCEEEEEEEEC	21.98	22499769
167	Ubiquitination	LQCVQCKKPITTGGV EEEEECCCCCCCCCC	49.64	22790023
220	Ubiquitination	FCDLYAKKCAGCTNP HHHHHHHHHCCCCCC	22.58	22790023
235	Ubiquitination	ISGLGGTKYISFEER CCCCCCCEEEECCCE	43.81	22790023
236	Phosphorylation	SGLGGTKYISFEERQ CCCCCCEEEECCCEE	11.13	25195567
238	Phosphorylation	LGGTKYISFEERQWH CCCCEEEECCCEECC	24.42	23737553
252	Ubiquitination	HNDCFNCKKCSLSLV CCCCCCCCCCCEEEE	58.90	22790023
253	Ubiquitination	NDCFNCKKCSLSLVG CCCCCCCCCCEEEEC	31.12	22790023
254	S-nitrosylation	DCFNCKKCSLSLVGR CCCCCCCCCEEEECC	2.79	21278135
254	S-nitrosocysteine	DCFNCKKCSLSLVGR CCCCCCCCCEEEECC	2.79	-
255	Phosphorylation	CFNCKKCSLSLVGRG CCCCCCCCEEEECCC	29.85	22817900
277	Ubiquitination	ILCPDCGKDI----- CCCCCCCCCC-----	59.59	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FHL2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FHL2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FHL2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF6_MOUSE	Traf6	physical	16184196
HAND1_MOUSE	Hand1	physical	15509787

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.