MYO15_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYO15_MOUSE
• UniProt AC: Q9QZZ4
• Protein Name: Unconventional myosin-XV
• Gene Name: Myo15a
• Organism: Mus musculus (Mouse).
• Sequence Length: 3511
• Subcellular Localization: Cell projection, stereocilium . Cytoplasm, cytoskeleton . Localizes to stereocilium tips in cochlear and vestibular hair cells.
• Protein Description: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). Required for the arrangement of stereocilia in mature hair bundles..
• Protein Sequence: MADEEKKAKKGKKGKKAPEPEKPKRSLKGTSRLFMGFRDRTPKISKKGQFRSASAFFWGLHTGPQKTKRKKKARTVLKSTSKLMTQMRVGKKKRAMKGKKPSFMVIRFPGRRGYGRLRPRAQSLSKASTAINWLTKKFLLKKAEESGSEQATVDAWLQRSSSRVGSRKLPFPSGAEILRHGGRLRRFPRSHSIYSSGEPVGFLPFEDEAPFRHAGSRKSLYGLEGFQDLGEYYDYHREGDDYYDQQSLYHYEEQEPYLAEFGGYSPAWPPYDDYGYPPGDPYNYYHPDYYGDTLYPGYAYGYGYGYDDFEPPYAPPSGYSSPYSYHDSFESEAYPYSYYLDPYATHHMPYPPYDFPYDTPYDIPYFDPYGVPYAEGVYGGGAEAIYPPGMPYVYPEEPAFMYPWVPPPIMSPHNPYAHPMDDIAELEEPEETGEERQSTSFRLPSAAFFEQQGMDKPARSKLSLIRKFRLFPRPQVKLFGKEKLEVPLPPSLDIPLPLGDAEGEEEEEEMPPVPTMPYTHPYWSFLTPRQRNLQRALSAFGARQGLGFGPEFGHPTPRPATSLARFLKKTLSEKKPIPRLRGSQKARGGRPPVREAAYKRFGYKLAGMDPDRPNTPIVLRRSQPQARNNNNSHGPPSPRPAPRALTHWSALISPPMPAPSPSPASPLTPPFSPTFSRPPRLASPYGSLRQHPPPWAAPAHVPFPPQANWWGFAEPPGTSPEVAPDLLAFPVPRPSFRASRSRSRRAAYGFPSPSLIGSRRRPHLPSPQPSLRSLPGQGYHSPLGPLSPQLSLRRGPFQPPFPPPPRRPQSLREAFSLRRASGRLGPPRSPVLGSPRPPSPPPLLKHGPRHRSLNLPSRLPRTWRRLSEPPTRAVKPWVHRAYPPPPSAGPWGASTGALEQQENQREAEDSETPWTVPPLAPSWDVDMPPTQRPPSPWPEGIGSLRGFSRPPPVPENPLLEHTSPSCEPQSEDRVSNLTGIFLGQHHDPGPGQLTKSADPSLEKPEEVVTLGDPQPPAEPEALNPTPPNKNVVSERKVLRLSASYPLVTCKQARATWPQWHRWKTVSRTPAPLAPTRAPGPLLKAGEQPRAEPGRFAVVMPQVRGVSSFRPKGPAPVQPPEHPDQDPEQGPAPQACSLRWPRLWPPTDAHCLWSRIRTYSSQSHLRGHGGDCHKSLWKKTRPQSWQNKMHSIRNLPSMRSREQHREDGVEDMTQLEDLQETTVLANLKTRFERNLIYTYIGSILVSVNPYRMFAIYGPEQVQQYSGRALGENPPHLFAIANLAFAKMLDAKQNQCVIISGESGSGKTEATKLILRCLAAMNQRRDVMQQIKILEATPLLEAFGNAKTVRNDNSSRFGKFVEIFLEGGVICGAITSQYLLEKSRIVFQAKNERNYHIFYELLAGLPAQLRQAFSLQEAETYYYLNQGGNCEIAGKSDADDFRRLLAAMEVLGFTSEDQDSIFRILASILHLGNVYFEKHETDAQEVASVVSAREIQAVAELLQVSPEGLQKAITFKVTETIREKIFTPLTVESAVDARDAIAKVLYALLFGWLITRVNALVSPKQDTLSIAILDIYGFEDLSFNSFEQLCINYANENLQYLFNKIVFQEEQEEYIREQMDWREIAFADNQPCINLISLKPYGILRILDDQCCFPQATDHTFLQKCHYHHGANPLYSKPKMPLPEFTIKHYAGKVTYQVHKFLDKNHDQVRQDVLDLFVHSRTRVVAHLFSSHAAQTAPPRLGKSSSITRLYKAHTVAAKFQQSLLDLVEKMERCNPLFVRCLKPNHKKEPGLFEPDVMMAQLRYSGVLETVRIRKEGFPVRLPFQVFIDRYRCLVALKLNVPADGDMCVSLLSRLCTVTPDMYRVGISKLFLKEHLHQLLESMRERVQNRAALTLQRYLRGFFIQRHFRSLRRKIILLQSRARGFLARQRYQQMRQSLLKFRSLVHTYVNRRRYLKLRAEQRRRAQEAWLREQEELSKREVVPVRHLEVPAEVAGLLQAAAGLKLSSGPRVAVVRAPRLQAEPCVTLPLDINNYPMAKFIRCHFKEPSFGMLTVPLKMPLTRLPVEHHAEAISVFKLILRFMGDPHLHGTQEMILGNYIVHQGLVEPALRDEILAQLANQVWRNPNAYNSKRGWLLLAACLSGFAPSPHLDKFLLKFVSDYGQNGFQAVCQHRLLQAMGSGAARTFPPTQLEWTAIQEKASMALDVSCFNGDQFSCPVHTWSTGEAVAGDILKHRGLADGWRGWTVAMKNGVQWAELAGHDYVLDLVSDLELLRDFPRQKSYFIVGAEGPLAGRGDTRGVFGNCWDSDEDTPTRPQPQDHVAKMPDLDGYCSHKEDGTNGETEAQRWTSNRQAVDSIGESTVPPRELDGYLDSLFDPVLACGDADLEKPTAIAYRMKGGGQPGGGGGSTSEDTSRRPPEPKLKPIPGLDASTLALQQAFIHRQAVLLAREMTLQALALQQQPLSATSRPQLPERPLAPEARPKTVVGTGPPAKPVLVRPTPQSWAPGSVAKAPKIPSKPVAVPILAQDWTAPESISASPELVRYSTLNSEHFPQPTQQIRSIIKQYKQPPWAGHPEARRTDGGKVFRRPPDPHEEALMILKGQKTQLAVVPGTQVSREAVAMVKPVTSAPRPCMGPTPVQPSRSLEPPEDPVQTQLHRLVNPNFYGYQDIPWRIFLRKEVFYPKDNYSHPVQLDLLFRQILHDTFSEACLRISEDERLQMKALFAQNQLDTQRPLVTESVKRAAISMARDSWEIYFSRLFPAMGSVGTGVQILAVSHTGIKLLQMVKGSKEASRRLRVLCAYSFADILFVTMPSQNMLEFNLSNEKLILFSARAQQVKTLVDTFILELKKDSDYVVAVRNFLSEDPELLSFHKGDIIHLQSLEPTRVGYSAGCVVRKKLVYLEELRRRGPDFGWRFGAVHGRVGRFPSELVQPAAAPDFLQLPAEPGRGRAAAVAAAVASAAAAQEVGRRREGPPVRARSADSGEDSIALPPSTMLEFAQKYFRDPRRRPRDGLKLKSKEDRESKTLEDVLCFTKVPIQESLIELSDSNLNKMAVDMFVAVMRFMGDAPLKGQSELDVLCTLLKLCGDHEVMRDECYCQIVKQITDNSSPKQDSCQRGWRLLYIMAAYYSCSEVFYPYLIRFLQHVSWTPGLPFQGIAKACEQNLQKTLRFGGRLEFPSNMELRAMLAGRSSKRQLFLLPGGLERHLKIKTCTVALDVIEGLCTEMALTRPEAFDEYVIFVVTNRGQHVCPLSCRAYILDVASEMEQVDGGYTLWFRRVLWDQPLKFENELYVTMHYNQVLPDYLKGLFSSVPARQPTEQQLQQVSKLASLQHRAKDHFYLPSVREVQEYIPAQLYHTTAGDTWLNLVSQHRQQTQALSPHQARAQFLGLLSAFPLFGSSFFFIQSCSNVLVPAPCILAVNHNGLNFLSTKTHELIVKIPLKEIQSTWTQQPTANSSYPYVEISLGDVAAQRTMQLQLEQGLELCRVVAVHVESMLSAREERLTLPPSEITLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Acetylation	EKKAKKGKKGKKAPE HHHHHCCCCCCCCCC	68.20	69597
13	Acetylation	KKAKKGKKGKKAPEP HHHHCCCCCCCCCCC	82.00	69601
125	Phosphorylation	RPRAQSLSKASTAIN CHHHHHHHHHHHHHH	31.27	22942356
135	Phosphorylation	STAINWLTKKFLLKK HHHHHHHHHHHHHHH	24.65	22942356
173	Phosphorylation	SRKLPFPSGAEILRH CCCCCCCCHHHHHHC	51.52	20495213
646	Phosphorylation	RPAPRALTHWSALIS CCCCCHHCCHHHHCC	21.95	26026062
649	Phosphorylation	PRALTHWSALISPPM CCHHCCHHHHCCCCC	12.95	26026062
653	Phosphorylation	THWSALISPPMPAPS CCHHHHCCCCCCCCC	24.65	26026062
672	Phosphorylation	SPLTPPFSPTFSRPP CCCCCCCCCCCCCCC	28.89	26026062
739	Phosphorylation	PRPSFRASRSRSRRA CCCCCCCCCCCCHHH	26.91	20531401
741	Phosphorylation	PSFRASRSRSRRAAY CCCCCCCCCCHHHHH	31.92	20531401
765 (in isoform 3)	Phosphorylation	-	40.71	-
791	Phosphorylation	GPLSPQLSLRRGPFQ CCCCCCCCCCCCCCC	18.00	22942356
810	Phosphorylation	PPPRRPQSLREAFSL CCCCCCHHHHHHHHH	31.88	28059163
816	Phosphorylation	QSLREAFSLRRASGR HHHHHHHHHHHHCCC	28.19	28059163
834	Phosphorylation	PRSPVLGSPRPPSPP CCCCCCCCCCCCCCC	17.36	27149854
852	Phosphorylation	KHGPRHRSLNLPSRL HCCCCCCCCCCCCCC	18.58	24759943
1000	Phosphorylation	LTKSADPSLEKPEEV CCCCCCCCCCCCCCE	50.11	26239621
1009	Phosphorylation	EKPEEVVTLGDPQPP CCCCCEEECCCCCCC	30.14	26239621
1025	Phosphorylation	EPEALNPTPPNKNVV CCHHCCCCCCCCCCC	50.75	26239621
1196	Phosphorylation	HSIRNLPSMRSREQH HHHHCCCHHHHHHHH	29.96	25266776
1346	Phosphorylation	EAFGNAKTVRNDNSS HHHCCCEEECCCCCC	23.45	-
1353	Phosphorylation	TVRNDNSSRFGKFVE EECCCCCCCCHHHHH	37.57	26824392
1684	Phosphorylation	KMPLPEFTIKHYAGK CCCCCCCEECEECCC	27.70	-
1952 (in isoform 2)	Phosphorylation	-	13.33	-
2578	Phosphorylation	GHPEARRTDGGKVFR CCCCHHCCCCCCEEC	33.18	-
2680	Phosphorylation	FLRKEVFYPKDNYSH EEECEEECCCCCCCC	17.97	26643407
2841	Phosphorylation	QVKTLVDTFILELKK HHHHHHHHHHHHCCC	12.70	-
2978	Phosphorylation	GPPVRARSADSGEDS CCCCCCCCCCCCCCC	35.13	21149613
2981	Phosphorylation	VRARSADSGEDSIAL CCCCCCCCCCCCCCC	43.74	21149613
2985	Phosphorylation	SADSGEDSIALPPST CCCCCCCCCCCCHHH	12.88	21149613
2991	Phosphorylation	DSIALPPSTMLEFAQ CCCCCCHHHHHHHHH	25.22	21149613
2992	Phosphorylation	SIALPPSTMLEFAQK CCCCCHHHHHHHHHH	31.39	21149613
3000	Phosphorylation	MLEFAQKYFRDPRRR HHHHHHHHHCCCCCC	7.55	21149613
3328	Phosphorylation	QQVSKLASLQHRAKD HHHHHHHHHHHHHHC	38.71	28059163
3427	Phosphorylation	HNGLNFLSTKTHELI CCCCCCCCCCCEEEE	24.58	23140645

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYO15_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYO15_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYO15_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MYO15_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.