dbPTM

CP131_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CP131_MOUSE
UniProt AC	Q62036
Protein Name	Centrosomal protein of 131 kDa
Gene Name	Cep131
Organism	Mus musculus (Mouse).
Sequence Length	1060
Subcellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasmic vesicle, secretory vesicle, acrosome .
Protein Description	Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation. In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner. Acts also as a negative regulator of BBSome ciliary trafficking (By similarity). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail. [PubMed: 24415959 Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability and centriole duplication in non-ciliogenic cells (By similarity Involved in centriole duplication]
Protein Sequence	MKGSRTITATPEGSPEAVDLSLIGLPPPMSQRPGSASATRSIFRSMSVATGSEPRKKALEATGPGGPRAINNLRRSNSTTQVNQSWTGSPRPAEPTDFLMLFEGSTSGRRRVASLSKASSEKEATWNVLDEQPRGLALPASAQSPSTLDSALGPRRKECPLAPSFTANNRSNKGAVGNCVTTMVHNHYASSKMVSPPKSSNQTAPSLNNIVKAAAREGGEGSDLGKPRKNLSSASQSARGTTGLLRRREVTEEEAERFIHQVNQAAVTIQRWYRCQVQRRRAGAAALEHLLASKREGQRQRLGGGNLLELHRQEEAARKKAREEKARQARQAAIQVLQQKRAQKASEAEHRRPKDRPETRAPEQPRPMQEPGCVTHPKANNAGASIYPTGPADPCPPASESSPEQWQSPEDKPQDIHSQGEARQDLAVSGSSRGKARARATLDDLLDTLKLLEEEPEPLPHPKAYHKDRYAWTDEEEDANSLTADNLEKFGKLSAAPGPPDDGTLLSEAKLQSIMTFLDEMEKSGQERPAPWRESLVLEAGSGSEGSTSVMRLKLELEEKKQAMALLQRALAQQRDLTVRRVKETEKELTRQLRQQKEQYEATIQRHLSFIDQLIEDKKVLSEKCEAVVAELKHGDQRCRERVAQMQEQHELEIKKLKELMSATEKIRREKWINEKTKKIKEITVRGLEPEIQKLIAKHKQEVRRLRGLHEAELQQREEQAAQRHLRQAEELRQHLDREREVLGQQERERAQQRFEQHLEQEQRALEQQRRRLYNEVAEEKERLGQQAARQRAELEELRQQLEESSAALTRALRAEFERSREEQERRHQMELKALKDQLEAERQAWVASCAKKEEAWLLTRERELKEEIRKGRDQEIELVIHRLEADMTLAKEESERAAESRVKRVRDKYETELSELEQSERKLQERCSELKGRLGEAEGEKERLQSLVRQKEKELEDLRAVNTQMCSERASLAQVVRQEFAEQLAASQEETQRVKVELAELQARQQVELDEVHRRVKTALARKEAAVNSLRKQHEAAVKRADHLEELLEQHKGSSLSSK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
6	Phosphorylation	--MKGSRTITATPEG --CCCCCEEEECCCC	25619855
8	Phosphorylation	MKGSRTITATPEGSP CCCCCEEEECCCCCH	25619855
10	Phosphorylation	GSRTITATPEGSPEA CCCEEEECCCCCHHH	25619855
14	Phosphorylation	ITATPEGSPEAVDLS EEECCCCCHHHEEHH	25619855
21	Phosphorylation	SPEAVDLSLIGLPPP CHHHEEHHHHCCCCC	25619855
30	Phosphorylation	IGLPPPMSQRPGSAS HCCCCCCCCCCCCHH	25619855
35	Phosphorylation	PMSQRPGSASATRSI CCCCCCCCHHHHHHH	25619855
37	Phosphorylation	SQRPGSASATRSIFR CCCCCCHHHHHHHHH	25619855
39	Phosphorylation	RPGSASATRSIFRSM CCCCHHHHHHHHHHH	25619855
45	Phosphorylation	ATRSIFRSMSVATGS HHHHHHHHHCCCCCC	24759943
47	Phosphorylation	RSIFRSMSVATGSEP HHHHHHHCCCCCCCH	25521595
76	Phosphorylation	AINNLRRSNSTTQVN HHHHHHHCCCCCCCC	23429704
78	Phosphorylation	NNLRRSNSTTQVNQS HHHHHCCCCCCCCCC	23684622
79	Phosphorylation	NLRRSNSTTQVNQSW HHHHCCCCCCCCCCC	23429704
80	Phosphorylation	LRRSNSTTQVNQSWT HHHCCCCCCCCCCCC	26643407
85	Phosphorylation	STTQVNQSWTGSPRP CCCCCCCCCCCCCCC	23984901
87	Phosphorylation	TQVNQSWTGSPRPAE CCCCCCCCCCCCCCC	23984901
89	Phosphorylation	VNQSWTGSPRPAEPT CCCCCCCCCCCCCCC	23984901
96	Phosphorylation	SPRPAEPTDFLMLFE CCCCCCCCCEEEEEE	26643407
105	Phosphorylation	FLMLFEGSTSGRRRV EEEEEECCCCCHHHH	-
114	Phosphorylation	SGRRRVASLSKASSE CCHHHHHHHHHCCCC	28066266
116	Phosphorylation	RRRVASLSKASSEKE HHHHHHHHHCCCCCC	28066266
119	Phosphorylation	VASLSKASSEKEATW HHHHHHCCCCCCCCC	28066266
120	Phosphorylation	ASLSKASSEKEATWN HHHHHCCCCCCCCCC	28066266
122	Ubiquitination	LSKASSEKEATWNVL HHHCCCCCCCCCCCC	-
141	Phosphorylation	RGLALPASAQSPSTL CCCCCCCCCCCCHHH	24068923
144	Phosphorylation	ALPASAQSPSTLDSA CCCCCCCCCHHHHHH	26824392
146	Phosphorylation	PASAQSPSTLDSALG CCCCCCCHHHHHHCC	24068923
147	Phosphorylation	ASAQSPSTLDSALGP CCCCCCHHHHHHCCC	24068923
150	Phosphorylation	QSPSTLDSALGPRRK CCCHHHHHHCCCCCC	24068923
164	Phosphorylation	KECPLAPSFTANNRS CCCCCCCCCCCCCCC	29514104
188	Phosphorylation	TTMVHNHYASSKMVS HHHHHHCCCCCCCCC	25367039
190	Phosphorylation	MVHNHYASSKMVSPP HHHHCCCCCCCCCCC	25367039
191	Phosphorylation	VHNHYASSKMVSPPK HHHCCCCCCCCCCCC	25367039
195	Phosphorylation	YASSKMVSPPKSSNQ CCCCCCCCCCCCCCC	24453211
199	Phosphorylation	KMVSPPKSSNQTAPS CCCCCCCCCCCCCCC	25293948
200	Phosphorylation	MVSPPKSSNQTAPSL CCCCCCCCCCCCCCH	25293948
203	Phosphorylation	PPKSSNQTAPSLNNI CCCCCCCCCCCHHHH	25293948
206	Phosphorylation	SSNQTAPSLNNIVKA CCCCCCCCHHHHHHH	27841257
222	Phosphorylation	AREGGEGSDLGKPRK HHHCCCCCCCCCCCC	28066266
229	Ubiquitination	SDLGKPRKNLSSASQ CCCCCCCCCHHHHHH	-
232	Phosphorylation	GKPRKNLSSASQSAR CCCCCCHHHHHHHHH	29514104
235	Phosphorylation	RKNLSSASQSARGTT CCCHHHHHHHHHCCC	29514104
251	Phosphorylation	LLRRREVTEEEAERF HHHHCCCCHHHHHHH	24719451
294	Ubiquitination	LEHLLASKREGQRQR HHHHHHCCCCCCCCC	-
385	Phosphorylation	KANNAGASIYPTGPA CCCCCCCCCCCCCCC	25293948
387	Phosphorylation	NNAGASIYPTGPADP CCCCCCCCCCCCCCC	25293948
389	Phosphorylation	AGASIYPTGPADPCP CCCCCCCCCCCCCCC	25293948
399	Phosphorylation	ADPCPPASESSPEQW CCCCCCCCCCCHHHH	25293948
401	Phosphorylation	PCPPASESSPEQWQS CCCCCCCCCHHHHCC	25293948
402	Phosphorylation	CPPASESSPEQWQSP CCCCCCCCHHHHCCC	25293948
408	Phosphorylation	SSPEQWQSPEDKPQD CCHHHHCCCCCCCCC	25293948
418	Phosphorylation	DKPQDIHSQGEARQD CCCCCCCCCCCHHHH	25293948
431	Phosphorylation	QDLAVSGSSRGKARA HHHCCCCCHHHHHHH	22006019
441	Phosphorylation	GKARARATLDDLLDT HHHHHHHHHHHHHHH	26643407
448	Phosphorylation	TLDDLLDTLKLLEEE HHHHHHHHHHHHHCC	27149854
450	Ubiquitination	DDLLDTLKLLEEEPE HHHHHHHHHHHCCCC	-
470	Phosphorylation	KAYHKDRYAWTDEEE CCCCCCCCCCCCCHH	25619855
473	Phosphorylation	HKDRYAWTDEEEDAN CCCCCCCCCCHHHHH	27087446
481	Phosphorylation	DEEEDANSLTADNLE CCHHHHHCCCHHHHH	27087446
483	Phosphorylation	EEDANSLTADNLEKF HHHHHCCCHHHHHHH	25619855
492	Ubiquitination	DNLEKFGKLSAAPGP HHHHHHCCCCCCCCC	-
494	Phosphorylation	LEKFGKLSAAPGPPD HHHHCCCCCCCCCCC	29514104
542	Phosphorylation	SLVLEAGSGSEGSTS EEEEECCCCCCCCHH	30635358
544	Phosphorylation	VLEAGSGSEGSTSVM EEECCCCCCCCHHHH	30635358
547	Phosphorylation	AGSGSEGSTSVMRLK CCCCCCCCHHHHHHE	30635358
548	Phosphorylation	GSGSEGSTSVMRLKL CCCCCCCHHHHHHEE	30635358
549	Phosphorylation	SGSEGSTSVMRLKLE CCCCCCHHHHHHEEH	30635358
600	Phosphorylation	LRQQKEQYEATIQRH HHHHHHHHHHHHHHH	22817900
1033	Methylation	AAVNSLRKQHEAAVK HHHHHHHHHHHHHHH	-
1056	Phosphorylation	LEQHKGSSLSSK--- HHHCCCCCCCCC---	29514104
1058	Phosphorylation	QHKGSSLSSK----- HCCCCCCCCC-----	29514104
1059	Phosphorylation	HKGSSLSSK------ CCCCCCCCC------	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CP131_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
47	S	Phosphorylation	21183079
MAPKAPK2-dependent phosphorylation at Ser-47 and Ser-78 occurs in response to cellular stress such as exposure to ultraviolet irradiation and promotes binding to 14-3-3 proteins which leads to cytoplasmic sequestration of CEP131 and blocks formation of new centriolar satellites (By similarity).
78	S	Phosphorylation	-
MAPKAPK2-dependent phosphorylation at Ser-47 and Ser-78 occurs in response to cellular stress such as exposure to ultraviolet irradiation and promotes binding to 14-3-3 proteins which leads to cytoplasmic sequestration of CEP131 and blocks formation of new centriolar satellites (By similarity).
78	S	Phosphorylation	-
Phosphorylation at Ser-78 mediated by PLK4 is essential for proper organization and integrity of centriolar satellites but is dispensable for its localization to centrioles and its function in ciliogenesis (By similarity).

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CP131_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CP131_HUMAN	CEP131	physical	20360068
IPO5_HUMAN	IPO5	physical	20360068
MIB1_HUMAN	MIB1	physical	20360068
PCM1_HUMAN	PCM1	physical	20360068
ATP5J_HUMAN	ATP5J	physical	26496610
BBS4_HUMAN	BBS4	physical	26496610
PCM1_HUMAN	PCM1	physical	26496610
MP2K1_HUMAN	MAP2K1	physical	26496610
OFD1_HUMAN	OFD1	physical	26496610
ARK72_HUMAN	AKR7A2	physical	26496610
DPM1_HUMAN	DPM1	physical	26496610
MOONR_HUMAN	KIAA0753	physical	26496610
CE350_HUMAN	CEP350	physical	26496610
HMGX4_HUMAN	HMGXB4	physical	26496610
PIBF1_HUMAN	PIBF1	physical	26496610
FR1OP_HUMAN	FGFR1OP	physical	26496610
RFIP2_HUMAN	RAB11FIP2	physical	26496610
TTLL5_HUMAN	TTLL5	physical	26496610
RT27_HUMAN	MRPS27	physical	26496610
WBP2_HUMAN	WBP2	physical	26496610
C2CD3_HUMAN	C2CD3	physical	26496610
RM18_HUMAN	MRPL18	physical	26496610
S18L2_HUMAN	SS18L2	physical	26496610
NIN_HUMAN	NIN	physical	26496610
HEAT3_HUMAN	HEATR3	physical	26496610
CEP72_HUMAN	CEP72	physical	26496610
MIB1_HUMAN	MIB1	physical	26496610
K1328_HUMAN	KIAA1328	physical	26496610
E41L5_HUMAN	EPB41L5	physical	26496610
RBM25_HUMAN	RBM25	physical	26496610
TFB2M_HUMAN	TFB2M	physical	26496610
RM11_HUMAN	MRPL11	physical	26496610
CSPP1_HUMAN	CSPP1	physical	26496610
FXRD2_HUMAN	FOXRED2	physical	26496610
YIPF5_HUMAN	YIPF5	physical	26496610
CCD77_HUMAN	CCDC77	physical	26496610
AT2L2_HUMAN	PHYKPL	physical	26496610
CE295_HUMAN	CEP295	physical	26496610
TBC31_HUMAN	TBC1D31	physical	26496610
ADIP_HUMAN	SSX2IP	physical	26496610
FOPNL_HUMAN	FOPNL	physical	26496610
CC138_HUMAN	CCDC138	physical	26496610
WDR90_HUMAN	WDR90	physical	26496610
CCD18_HUMAN	CCDC18	physical	26496610
CCD61_HUMAN	CCDC61	physical	26496610

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CP131_MOUSE

Related Literatures of Post-Translational Modification

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