K1328_HUMAN - dbPTM
K1328_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID K1328_HUMAN
UniProt AC Q86T90
Protein Name Protein hinderin {ECO:0000303|PubMed:15656913}
Gene Name KIAA1328
Organism Homo sapiens (Human).
Sequence Length 577
Subcellular Localization
Protein Description Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes..
Protein Sequence MADVAGPSRPSAAAFWSRDFSDEEQSVVYVPGISAEGNVRSRHKLMSPKADVKLKTSRVTDASISMESLKGTGDSVDEQNSCRGEIKSASLKDLCLEDKRRIANLIKELARVSEEKEVTEERLKAEQESFEKKIRQLEEQNELIIKEREALQLQYRECQELLSLYQKYLSEQQEKLTMSLSELGAARMQEQQVSSRKSTLQCSSVELDGSYLSIARPQTYYQTKQRPKSAVQDSASESLIAFRNNSLKPVTLHHPKDDLDKIPSETTTCNCESPGRKPAVPTEKMPQEELHMKECPHLKPTPSQCCGHRLAADRVHDSHPTNMTPQHPKTHPESCSYCRLSWASLVHGGGALQPIETLKKQISEDRKQQLMLQKMELEIEKERLQHLLAQQETKLLLKQQQLHQSRLDYNCLLKSNCDGWLLGTSSSIKKHQDPPNSGENRKERKTVGFHSHMKDDAQWSCQKKDTCRPQRGTVTGVRKDASTSPMPTGSLKDFVTTASPSLQHTTSRYETSLLDLVQSLSPNSAPKPQRYPSREAGAWNHGTFRLSPLKSTRKKMGMHRTPEELEENQILEDIFFI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
21PhosphorylationAFWSRDFSDEEQSVV
HHHCCCCCCCCCEEE		48.6930175587
26PhosphorylationDFSDEEQSVVYVPGI
CCCCCCCEEEECCCC		19.4830576142
29PhosphorylationDEEQSVVYVPGISAE
CCCCEEEECCCCCCC		9.9628450419
34PhosphorylationVVYVPGISAEGNVRS
EEECCCCCCCCCCCC		26.6127251275
47PhosphorylationRSRHKLMSPKADVKL
CCCCCCCCCCCCCEE		33.4117001009
56PhosphorylationKADVKLKTSRVTDAS
CCCCEEECCCCCCCE		32.0023911959
60PhosphorylationKLKTSRVTDASISME
EEECCCCCCCEEEHH		25.4123911959
63PhosphorylationTSRVTDASISMESLK
CCCCCCCEEEHHHHC		20.2923911959
65PhosphorylationRVTDASISMESLKGT
CCCCCEEEHHHHCCC		17.6326471730
68PhosphorylationDASISMESLKGTGDS
CCEEEHHHHCCCCCC		27.0922777824
70UbiquitinationSISMESLKGTGDSVD
EEEHHHHCCCCCCCC		64.8032015554
75PhosphorylationSLKGTGDSVDEQNSC
HHCCCCCCCCCCCCC		32.5828348404
75UbiquitinationSLKGTGDSVDEQNSC
HHCCCCCCCCCCCCC		32.5832015554
81PhosphorylationDSVDEQNSCRGEIKS
CCCCCCCCCCCCCCC		12.6025159151
88PhosphorylationSCRGEIKSASLKDLC
CCCCCCCCCCHHHHH		28.8427251275
90PhosphorylationRGEIKSASLKDLCLE
CCCCCCCCHHHHHHH		42.9424719451
92UbiquitinationEIKSASLKDLCLEDK
CCCCCCHHHHHHHHH		46.2729967540
130UbiquitinationLKAEQESFEKKIRQL
HHHHHHHHHHHHHHH		18.3632015554
133AcetylationEQESFEKKIRQLEEQ
HHHHHHHHHHHHHHH		35.607299041
146AcetylationEQNELIIKEREALQL
HHHHHHHHHHHHHHH		43.667299049
167UbiquitinationELLSLYQKYLSEQQE
HHHHHHHHHHHHHHH		34.3029967540
177PhosphorylationSEQQEKLTMSLSELG
HHHHHHHHHCHHHHH		18.7823186163
179PhosphorylationQQEKLTMSLSELGAA
HHHHHHHCHHHHHHH		24.4123403867
195PhosphorylationMQEQQVSSRKSTLQC
HHHHHHHCCCCEEEE		44.8924114839
203PhosphorylationRKSTLQCSSVELDGS
CCCEEEEEEEEECCC		25.1828348404
204PhosphorylationKSTLQCSSVELDGSY
CCEEEEEEEEECCCE		27.5128348404
210PhosphorylationSSVELDGSYLSIARP
EEEEECCCEEEEECC		23.6727251275
220PhosphorylationSIARPQTYYQTKQRP
EEECCCCEECCCCCC		6.58-
229PhosphorylationQTKQRPKSAVQDSAS
CCCCCCCHHHCCCCC		36.0328857561
234PhosphorylationPKSAVQDSASESLIA
CCHHHCCCCCCHHHH		19.3225072903
236PhosphorylationSAVQDSASESLIAFR
HHHCCCCCCHHHHHH		31.5025072903
238PhosphorylationVQDSASESLIAFRNN
HCCCCCCHHHHHHCC		23.6825072903
246PhosphorylationLIAFRNNSLKPVTLH
HHHHHCCCCCCEEEC		41.1220873877
248UbiquitinationAFRNNSLKPVTLHHP
HHHCCCCCCEEECCC		36.9429967540
251PhosphorylationNNSLKPVTLHHPKDD
CCCCCCEEECCCCCC		28.9720873877
251UbiquitinationNNSLKPVTLHHPKDD
CCCCCCEEECCCCCC		28.9732015554
261UbiquitinationHPKDDLDKIPSETTT
CCCCCHHHCCCCCCC		64.9129967540
264PhosphorylationDDLDKIPSETTTCNC
CCHHHCCCCCCCCCC		51.5628348404
266PhosphorylationLDKIPSETTTCNCES
HHHCCCCCCCCCCCC		31.5728348404
267PhosphorylationDKIPSETTTCNCESP
HHCCCCCCCCCCCCC		25.8727251275
268PhosphorylationKIPSETTTCNCESPG
HCCCCCCCCCCCCCC		14.7829449344
273PhosphorylationTTTCNCESPGRKPAV
CCCCCCCCCCCCCCC		34.5523663014
306UbiquitinationKPTPSQCCGHRLAAD
CCCHHHCCCCHHHHC		3.8932015554
324PhosphorylationDSHPTNMTPQHPKTH
CCCCCCCCCCCCCCC		23.1328348404
341PhosphorylationSCSYCRLSWASLVHG
CCCHHCCCHHHHHCC		10.9728348404
344PhosphorylationYCRLSWASLVHGGGA
HHCCCHHHHHCCCCC		25.3527251275
355UbiquitinationGGGALQPIETLKKQI
CCCCCHHHHHHHHHC		3.9932015554
359UbiquitinationLQPIETLKKQISEDR
CHHHHHHHHHCCHHH		50.4832015554
360UbiquitinationQPIETLKKQISEDRK
HHHHHHHHHCCHHHH		56.85-
367UbiquitinationKQISEDRKQQLMLQK
HHCCHHHHHHHHHHH		55.5129967540
381UbiquitinationKMELEIEKERLQHLL
HHHHHHHHHHHHHHH		54.5229967540
394UbiquitinationLLAQQETKLLLKQQQ
HHHHHHHHHHHHHHH		36.0629967540
398UbiquitinationQETKLLLKQQQLHQS
HHHHHHHHHHHHHHH		46.1329967540
410UbiquitinationHQSRLDYNCLLKSNC
HHHCCCHHHHHHCCC		15.0432015554
414UbiquitinationLDYNCLLKSNCDGWL
CCHHHHHHCCCCCEE		27.0332015554
427PhosphorylationWLLGTSSSIKKHQDP
EEECCHHHHHHCCCC		37.8923186163
437PhosphorylationKHQDPPNSGENRKER
HCCCCCCCCCCHHHC		53.9427251275
482PhosphorylationTGVRKDASTSPMPTG
EEEECCCCCCCCCCC		39.2828450419
483PhosphorylationGVRKDASTSPMPTGS
EEECCCCCCCCCCCC		38.2728450419
484PhosphorylationVRKDASTSPMPTGSL
EECCCCCCCCCCCCH		19.3925159151
488PhosphorylationASTSPMPTGSLKDFV
CCCCCCCCCCHHHHH		32.9022199227
490PhosphorylationTSPMPTGSLKDFVTT
CCCCCCCCHHHHHHC		34.4222617229
496PhosphorylationGSLKDFVTTASPSLQ
CCHHHHHHCCCHHHC		19.3526657352
497PhosphorylationSLKDFVTTASPSLQH
CHHHHHHCCCHHHCC		21.6028450419
499PhosphorylationKDFVTTASPSLQHTT
HHHHHCCCHHHCCCC		16.9628450419
501PhosphorylationFVTTASPSLQHTTSR
HHHCCCHHHCCCCCH		37.8628450419
505PhosphorylationASPSLQHTTSRYETS
CCHHHCCCCCHHHHH		17.3228450419
506PhosphorylationSPSLQHTTSRYETSL
CHHHCCCCCHHHHHH		14.7428450419
507PhosphorylationPSLQHTTSRYETSLL
HHHCCCCCHHHHHHH		33.7428450419
509PhosphorylationLQHTTSRYETSLLDL
HCCCCCHHHHHHHHH		24.2727251275
511PhosphorylationHTTSRYETSLLDLVQ
CCCCHHHHHHHHHHH		18.7526074081
512PhosphorylationTTSRYETSLLDLVQS
CCCHHHHHHHHHHHH		18.2626074081
519PhosphorylationSLLDLVQSLSPNSAP
HHHHHHHHCCCCCCC		24.2830108239
521PhosphorylationLDLVQSLSPNSAPKP
HHHHHHCCCCCCCCC		27.5526657352
524PhosphorylationVQSLSPNSAPKPQRY
HHHCCCCCCCCCCCC		49.7030108239
531PhosphorylationSAPKPQRYPSREAGA
CCCCCCCCCCCCCCC		10.5826074081
533PhosphorylationPKPQRYPSREAGAWN
CCCCCCCCCCCCCCC		33.5427251275
543PhosphorylationAGAWNHGTFRLSPLK
CCCCCCCCEECCCCH		9.6823898821
547PhosphorylationNHGTFRLSPLKSTRK
CCCCEECCCCHHHHH		24.7527251275
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of K1328_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of K1328_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of K1328_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of K1328_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of K1328_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-484, AND MASSSPECTROMETRY.

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