AT2L2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AT2L2_HUMAN
• UniProt AC: Q8IUZ5
• Protein Name: 5-phosphohydroxy-L-lysine phospho-lyase
• Gene Name: PHYKPL
• Organism: Homo sapiens (Human).
• Sequence Length: 450
• Subcellular Localization: Mitochondrion .
• Protein Description: Catalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde..
• Protein Sequence: MAADQRPKADTLALRQRLISSSCRLFFPEDPVKIVRAQGQYMYDEQGAEYIDCISNVAHVGHCHPLVVQAAHEQNQVLNTNSRYLHDNIVDYAQRLSETLPEQLCVFYFLNSGSEANDLALRLARHYTGHQDVVVLDHAYHGHLSSLIDISPYKFRNLDGQKEWVHVAPLPDTYRGPYREDHPNPAMAYANEVKRVVSSAQEKGRKIAAFFAESLPSVGGQIIPPAGYFSQVAEHIRKAGGVFVADEIQVGFGRVGKHFWAFQLQGKDFVPDIVTMGKSIGNGHPVACVAATQPVARAFEATGVEYFNTFGGSPVSCAVGLAVLNVLEKEQLQDHATSVGSFLMQLLGQQKIKHPIVGDVRGVGLFIGVDLIKDEATRTPATEEAAYLVSRLKENYVLLSTDGPGRNILKFKPPMCFSLDNARQVVAKLDAILTDMEEKVRSCETLRLQP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Ubiquitination	MAADQRPKADTLALR CCCCCCCCHHHHHHH	62.17	-
11	Phosphorylation	DQRPKADTLALRQRL CCCCCHHHHHHHHHH	20.84	28857561
20	Phosphorylation	ALRQRLISSSCRLFF HHHHHHHHHCCCEEC	22.31	28857561
21	Phosphorylation	LRQRLISSSCRLFFP HHHHHHHHCCCEECC	26.85	28857561
22	Phosphorylation	RQRLISSSCRLFFPE HHHHHHHCCCEECCC	9.10	28857561
33	Acetylation	FFPEDPVKIVRAQGQ ECCCCCHHEEEECCC	40.65	19608861
33	Ubiquitination	FFPEDPVKIVRAQGQ ECCCCCHHEEEECCC	40.65	-
121	Ubiquitination	SEANDLALRLARHYT CHHHHHHHHHHHHHC	6.32	29967540
151	Phosphorylation	LSSLIDISPYKFRNL HHHCCCCCCCEEECC	20.59	26091039
153	Phosphorylation	SLIDISPYKFRNLDG HCCCCCCCEEECCCC	18.90	46160631
162	Ubiquitination	FRNLDGQKEWVHVAP EECCCCCCCEEEEEC	60.10	29967540
278	Other	PDIVTMGKSIGNGHP CCEEEECCCCCCCCC	28.25	-
278	Ubiquitination	PDIVTMGKSIGNGHP CCEEEECCCCCCCCC	28.25	-
278	N6-(pyridoxal phosphate)lysine	PDIVTMGKSIGNGHP CCEEEECCCCCCCCC	28.25	-
279	Phosphorylation	DIVTMGKSIGNGHPV CEEEECCCCCCCCCC	29.96	28857561
352	Ubiquitination	QLLGQQKIKHPIVGD HHHCCCCCCCCCCCC	4.27	29967540
353	Ubiquitination	LLGQQKIKHPIVGDV HHCCCCCCCCCCCCC	50.82	-
393	Ubiquitination	AYLVSRLKENYVLLS HHHHHHHHHCEEEEE	42.68	29967540
398	Ubiquitination	RLKENYVLLSTDGPG HHHHCEEEEECCCCC	1.89	29967540
439	Ubiquitination	ILTDMEEKVRSCETL HHHCHHHHHHCCHHC	29.64	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AT2L2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AT2L2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AT2L2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AT2L2_HUMAN	PHYKPL	physical	16189514
AT2L2_HUMAN	PHYKPL	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.