KI21B_MOUSE - dbPTM
KI21B_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KI21B_MOUSE
UniProt AC Q9QXL1
Protein Name Kinesin-like protein KIF21B
Gene Name Kif21b
Organism Mus musculus (Mouse).
Sequence Length 1668
Subcellular Localization Cytoplasm, cytoskeleton . Cell projection, dendrite . Cell projection, growth cone . Cell projection, axon . Cytoplasmic vesicle .
Protein Description Plus-end directed microtubule-dependent motor protein which displays processive activity. [PubMed: 27117409]
Protein Sequence MAGQGDCCVKVAVRIRPQLSKEKIEGCHICTSVTPGEPQVLLGKDKAFTYDFVFDLDTWQEQIYSTCVSKLIEGCFEGYNATVLAYGQTGAGKTYTMGTGFDTVTSEEEQGIIPRAIAHLFRGIDERKRRAQEKGVTGPEFKVSAQFLELYNEEILDLFDSTRDPDARHRRSNIKIHEDANGGIYTTGVTSRLINSQEELIQCLKQGALSRTTASTQMNVQSSRSHAIFTIHLCQMRVCAQPDLVNETVTGLPDGAAPTGTEYETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDQSKKVVHVPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVVVNQDKTSQQISALRAEIARLQMELMEYKAGKRVIGEDGTEGYSDLFRENAMLQKENGALRLRVKAMQEAIDAINNRVTQLMSQEANLLLAKAGDGNEAIGALIQNYIREIEELRTKLLESEAMNESLRRSLSRASARNPYSLGASPAGPAFGGSPATSMEDASEVIRKAKQDLERLKKKEVRQRRKSPEKEAFKKRAKLQAENSEETDENEAEEEEEERDESGCEEEEGREDEDEDSGSEESLVDSDSDPEEKEVNFQADLADLTCEIEIKQKLIDELENSQRRLQTLKHQYEEKLILLQNKIRDTQLERDRVLQNLSTMECYTEEKANKIKADYEKRLREMNRDLQKLQAAQKEHARLLKNQSRYERELKKLQAEVAEMKKAKVALMKQMREEQQRRRLVETKRNREIAQLKKEQRRQEFQIRALESQKRQQEIVLRRKTQEVSALRRLAKPMSERVAGRVGLKPPNMDSGAEVSASTTSSEAESGARSVSSIVRQWNRKIDHFLGDRPTATVNGGRPARKKFQKKGASQSFSKAARLKWQSLERRIIDIVMQRMTIVNLEADMERLIKKREELFLLQEALRRKREHLQAESPEEEKGLQELAEEIEVLAANIDYINDSITDCQATIVQLEETKEELDSTDTSVVISSCSLAEARLLLDNFLKASIDKGLQVAQKEAQIRLLEGRLRQTDMTGSSQNHLLLDALREKAEAHPELQALIYNVQHENGYASTDEEVSEFSEGSFSQSFTMKGSTSHDDFKFKGEPKLSAQMKAVSAECLGPPLDSSTKNITKSLASLVEIKEDGVGFSIRDPYYRDKVSRTVSLPTRGSTFPRQSRGATDTSPLTRRKSYDRGQPIRSTDMGFTPPSSPPTRPRNDRNVFSRLTSNQSQGSALDKSDDSDSSLSEVLRGIITPIGGAKGARTAPLQCISMAEGHTKPILCLDATDELLFTGSKDRSCKMWNLVTGQEIAALKGHPNNVVSIKYCSHSGLVFSVSSSYIKVWDIRDSAKCIRTLTSSGQVISGDACIATSTRAITSAQGEHQINQMALSPSGSMLYVASGNAVRIWELNRFQPIGKLTGHIGPVMCLTVTQTSNQHDLVVTGSKDHYVKMFQLGDCVTGTIGPTHNFEPPHYDGIECLAIQGDILFSGSRDNGIKKWDLDQQELIQQIPNAHKDWVCALAFVPGRPMLLSACRAGFIKVWNVDNFTPIGEIKGHDSPINAICTNSKHIFTASSDCRVKLWNYVPGLTPCLPRRVLAIKGRAPPCPDLPPPPLTLPILPFPVFPPPRSELLLHVT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
212PhosphorylationKQGALSRTTASTQMN
HHCCCCCCCCCCCCC		24.2830482847
222PhosphorylationSTQMNVQSSRSHAIF
CCCCCCCCCCCCEEE		24.3625521595
223PhosphorylationTQMNVQSSRSHAIFT
CCCCCCCCCCCEEEE		22.2529514104
278PhosphorylationHFVDLAGSERLKRTG
EEEECCCCHHHHHCC		17.59-
287O-linked_GlycosylationRLKRTGATGERAKEG
HHHHCCCCCCHHHCC		40.7030059200
383PhosphorylationVVNQDKTSQQISALR
EECCCCHHHHHHHHH		26.3128059163
496PhosphorylationLRTKLLESEAMNESL
HHHHHHHHHHHHHHH		30.5325338131
563PhosphorylationEVRQRRKSPEKEAFK
HHHHHHCCHHHHHHH		36.16-
580PhosphorylationAKLQAENSEETDENE
HHHHHHCCCCCCCCH		28.4515345747
583PhosphorylationQAENSEETDENEAEE
HHHCCCCCCCCHHHH		44.5615345747
847PhosphorylationLKPPNMDSGAEVSAS
CCCCCCCCCCEECEE		29.1821183079
852PhosphorylationMDSGAEVSASTTSSE
CCCCCEECEECCCHH		14.1725293948
854PhosphorylationSGAEVSASTTSSEAE
CCCEECEECCCHHHH		25.3925293948
855PhosphorylationGAEVSASTTSSEAES
CCEECEECCCHHHHH		30.3425293948
856PhosphorylationAEVSASTTSSEAESG
CEECEECCCHHHHHC		27.9725293948
857PhosphorylationEVSASTTSSEAESGA
EECEECCCHHHHHCC		26.6925293948
858PhosphorylationVSASTTSSEAESGAR
ECEECCCHHHHHCCC		38.4425293948
862PhosphorylationTTSSEAESGARSVSS
CCCHHHHHCCCCHHH		44.8125293948
906PhosphorylationKFQKKGASQSFSKAA
HHHHCCCCCCHHHHH		34.7230635358
908PhosphorylationQKKGASQSFSKAARL
HHCCCCCCHHHHHHH		29.0624453211
910PhosphorylationKGASQSFSKAARLKW
CCCCCCHHHHHHHHH		26.9930635358
969PhosphorylationREHLQAESPEEEKGL
HHHHHCCCHHHHHHH		40.4030372032
1128PhosphorylationQSFTMKGSTSHDDFK
CCEEECCCCCCCCCC		22.6329899451
1129PhosphorylationSFTMKGSTSHDDFKF
CEEECCCCCCCCCCC		38.4630635358
1130PhosphorylationFTMKGSTSHDDFKFK
EEECCCCCCCCCCCC		26.9830635358
1150PhosphorylationSAQMKAVSAECLGPP
HHHHEEHHHHHHCCC		24.1825521595
1168PhosphorylationSTKNITKSLASLVEI
CCCHHHHHHHHHHEE		22.1025521595
1171PhosphorylationNITKSLASLVEIKED
HHHHHHHHHHEEECC		37.9428833060
1196PhosphorylationYRDKVSRTVSLPTRG
HCCCCCCEEECCCCC		13.6226745281
1198PhosphorylationDKVSRTVSLPTRGST
CCCCCEEECCCCCCC		28.1927180971
1201PhosphorylationSRTVSLPTRGSTFPR
CCEEECCCCCCCCCC		53.6127600695
1204PhosphorylationVSLPTRGSTFPRQSR
EECCCCCCCCCCCCC		24.4726745281
1205PhosphorylationSLPTRGSTFPRQSRG
ECCCCCCCCCCCCCC		40.2526745281
1214PhosphorylationPRQSRGATDTSPLTR
CCCCCCCCCCCCCCC		42.5124899341
1216PhosphorylationQSRGATDTSPLTRRK
CCCCCCCCCCCCCCC		28.0824453211
1217PhosphorylationSRGATDTSPLTRRKS
CCCCCCCCCCCCCCC		22.2625521595
1220PhosphorylationATDTSPLTRRKSYDR
CCCCCCCCCCCCCCC		31.6322817900
1224PhosphorylationSPLTRRKSYDRGQPI
CCCCCCCCCCCCCCC		30.3827600695
1225PhosphorylationPLTRRKSYDRGQPIR
CCCCCCCCCCCCCCC		16.8229899451
1233PhosphorylationDRGQPIRSTDMGFTP
CCCCCCCCCCCCCCC		29.4928833060
1234PhosphorylationRGQPIRSTDMGFTPP
CCCCCCCCCCCCCCC		21.8428833060
1239PhosphorylationRSTDMGFTPPSSPPT
CCCCCCCCCCCCCCC		28.6727087446
1242PhosphorylationDMGFTPPSSPPTRPR
CCCCCCCCCCCCCCC		57.5923527152
1243PhosphorylationMGFTPPSSPPTRPRN
CCCCCCCCCCCCCCC		40.4427087446
1246PhosphorylationTPPSSPPTRPRNDRN
CCCCCCCCCCCCCCC		57.6028833060
1259PhosphorylationRNVFSRLTSNQSQGS
CCHHHHHCCCCCCCC		25.2325293948
1260PhosphorylationNVFSRLTSNQSQGSA
CHHHHHCCCCCCCCC		37.1525293948
1263PhosphorylationSRLTSNQSQGSALDK
HHHCCCCCCCCCCCC		40.5325293948
1266PhosphorylationTSNQSQGSALDKSDD
CCCCCCCCCCCCCCC		20.3030372032
1271PhosphorylationQGSALDKSDDSDSSL
CCCCCCCCCCCCCCH		46.4425521595
1274PhosphorylationALDKSDDSDSSLSEV
CCCCCCCCCCCHHHH		44.3728418008
1276PhosphorylationDKSDDSDSSLSEVLR
CCCCCCCCCHHHHHH		36.8125293948
1277PhosphorylationKSDDSDSSLSEVLRG
CCCCCCCCHHHHHHH		40.6925293948
1279PhosphorylationDDSDSSLSEVLRGII
CCCCCCHHHHHHHHH		27.8325293948
1355PhosphorylationGHPNNVVSIKYCSHS
CCCCCEEEEEECCCC		14.7428576409
1362PhosphorylationSIKYCSHSGLVFSVS
EEEECCCCCEEEEEE		19.9622871156
1367PhosphorylationSHSGLVFSVSSSYIK
CCCCEEEEEECCEEE		17.3822871156
1621PhosphorylationWNYVPGLTPCLPRRV
HHCCCCCCCCCCCCH		20.1920415495
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KI21B_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KI21B_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KI21B_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TCPZ_HUMANCCT6Aphysical
26496610
TCPA_HUMANTCP1physical
26496610
TCPG_HUMANCCT3physical
26496610
TP4A1_HUMANPTP4A1physical
26496610
TP4A2_HUMANPTP4A2physical
26496610
TCPH_HUMANCCT7physical
26496610
TCPD_HUMANCCT4physical
26496610
TCPB_HUMANCCT2physical
26496610
TCPE_HUMANCCT5physical
26496610
KI21A_HUMANKIF21Aphysical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KI21B_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-580 AND THR-583, ANDMASS SPECTROMETRY.

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