PACS1_MOUSE - dbPTM
PACS1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PACS1_MOUSE
UniProt AC Q8K212
Protein Name Phosphofurin acidic cluster sorting protein 1
Gene Name Pacs1
Organism Mus musculus (Mouse).
Sequence Length 961
Subcellular Localization Golgi apparatus, trans-Golgi network . Localizes in the perinuclear region, probably the TGN.
Protein Description Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits (By similarity)..
Protein Sequence MAERGGAGGGPGGSGGGSSQRGSGVAQSPQQQPQQQPPQPQQPTPPKLAQATSSSSSTSAAAASSSSSSTSTSMAVAVASGSAPPGGPGPGRTPAPVQMNLYATWEVDRSSSSCVPRLFSLTLKKLVMLKEMDKDLNSVVIAVKLQGSKRILRSNEIILPASGLVETELQLTFSLQYPHFLKRDANKLQIMLQRRKRYKNRTILGYKTLAVGLINMAEVMQHPNEGALVLGLHSNVKDVSVPVAEIKIYSLSSQPIDHEGIKSKLSDRSPDIDNYSEEEEESFSSEQEGSDDPLHGQDLFYEDEDLRKVKKTRRKLTSTSAITRQPNIKQKFVALLKRFKVSDEVGFGLEHVSREQIREVEEDLDELYDSLEMYNPSDSGPEMEETESILSTPKPKLKPFFEGMSQSSSQTEIGSLNSKGSLGKDTTSPMELAALEKVKSTWIKNQDDSLTETDTLEITDQDMFGDVSTSLVVPEKVKTPMKSSKADLQGSASPSKVEGTHTPRQKRSTPLKERQLSKPLSERTNSSDSERSPDLGHSTQIPRKVVYDQLNQILVSDAALPENVILVNTTDWQGQYVAELLQDQRKPVVCTCSTVEVQAVLSALLTRIQRYCNCNSSMPRPVKVAAVGSQSYLSSILRFFVKSLASKTPDWLGYMRFLIIPLGSHPVAKYLGSVDSRYSSTFLDSAWRDLFSRSEPPVSEPLDVVGRVMQYVNGATTTHQLPVAEAMLTCRHKFPDEDSYQKFIPFIGVVKVGLVEDSPSTAGDGDDSPVVSLTVPSTSPPSSSGLSRDATATPPSSPSMSSALAIVGSPNSPYGDVIGLQVDYWLGHPGERRREGDKRDASSKNTLKSVFRSVQVSRLPHAGEAQLSGTMAMTVVTKEKNKKVPTIFLSKKPREKEVDSKSQVIEGISRLICSAKQQQTMLRVSIDGVEWSDIKFFQLAAQWPTHVKHFPVGLFSGSKTT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAERGGAGG
------CCCCCCCCC		18.39-
14PhosphorylationAGGGPGGSGGGSSQR
CCCCCCCCCCCCCCC		39.9322802335
18PhosphorylationPGGSGGGSSQRGSGV
CCCCCCCCCCCCCCC		26.9429899451
19PhosphorylationGGSGGGSSQRGSGVA
CCCCCCCCCCCCCCC		27.4629899451
23PhosphorylationGGSSQRGSGVAQSPQ
CCCCCCCCCCCCCCC		32.0825619855
28PhosphorylationRGSGVAQSPQQQPQQ
CCCCCCCCCCCCCCC		18.2225521595
44PhosphorylationPPQPQQPTPPKLAQA
CCCCCCCCCCHHHHH		48.1325521595
134UbiquitinationVMLKEMDKDLNSVVI
HHHHHHCCCCCCEEE		63.91-
138PhosphorylationEMDKDLNSVVIAVKL
HHCCCCCCEEEEEEE		25.6725521595
187UbiquitinationFLKRDANKLQIMLQR
HHHCCHHHHHHHHHH		43.4122790023
249PhosphorylationPVAEIKIYSLSSQPI
EEEEEEEEECCCCCC		9.8821082442
250PhosphorylationVAEIKIYSLSSQPID
EEEEEEEECCCCCCC		25.8326026062
276PhosphorylationSPDIDNYSEEEEESF
CCCCCCCCHHHHHHH		44.8029899451
282PhosphorylationYSEEEEESFSSEQEG
CCHHHHHHHCCCCCC		33.4429899451
284PhosphorylationEEEEESFSSEQEGSD
HHHHHHHCCCCCCCC		42.0929899451
285PhosphorylationEEEESFSSEQEGSDD
HHHHHHCCCCCCCCC		41.0929899451
290PhosphorylationFSSEQEGSDDPLHGQ
HCCCCCCCCCCCCCC		37.7829899451
317PhosphorylationKKTRRKLTSTSAITR
HHHHHHHHCCCHHHC		32.7525266776
318PhosphorylationKTRRKLTSTSAITRQ
HHHHHHHCCCHHHCC		30.7025266776
319PhosphorylationTRRKLTSTSAITRQP
HHHHHHCCCHHHCCC		19.5528066266
320PhosphorylationRRKLTSTSAITRQPN
HHHHHCCCHHHCCCC		19.9028066266
323PhosphorylationLTSTSAITRQPNIKQ
HHCCCHHHCCCCHHH		23.9829176673
337UbiquitinationQKFVALLKRFKVSDE
HHHHHHHHHCCCCCC		57.5522790023
353PhosphorylationGFGLEHVSREQIREV
CCCCCCCCHHHHHHH		31.8226824392
368PhosphorylationEEDLDELYDSLEMYN
HHHHHHHHHHHHHHC		11.0523737553
370PhosphorylationDLDELYDSLEMYNPS
HHHHHHHHHHHHCCC		16.8123737553
374PhosphorylationLYDSLEMYNPSDSGP
HHHHHHHHCCCCCCC		17.9723737553
377PhosphorylationSLEMYNPSDSGPEME
HHHHHCCCCCCCCHH		40.5523737553
379PhosphorylationEMYNPSDSGPEMEET
HHHCCCCCCCCHHHH		61.6623737553
386PhosphorylationSGPEMEETESILSTP
CCCCHHHHHHHHCCC		23.0223737553
388PhosphorylationPEMEETESILSTPKP
CCHHHHHHHHCCCCC		35.9323737553
391PhosphorylationEETESILSTPKPKLK
HHHHHHHCCCCCCCC		40.7823737553
392PhosphorylationETESILSTPKPKLKP
HHHHHHCCCCCCCCH		31.7023737553
405PhosphorylationKPFFEGMSQSSSQTE
CHHHCCCCCCCCCCC		37.4528833060
407PhosphorylationFFEGMSQSSSQTEIG
HHCCCCCCCCCCCCC		25.3428833060
408PhosphorylationFEGMSQSSSQTEIGS
HCCCCCCCCCCCCCC		20.8728833060
409PhosphorylationEGMSQSSSQTEIGSL
CCCCCCCCCCCCCCC		46.5028833060
411PhosphorylationMSQSSSQTEIGSLNS
CCCCCCCCCCCCCCC		31.3628833060
415PhosphorylationSSQTEIGSLNSKGSL
CCCCCCCCCCCCCCC		30.0028833060
418PhosphorylationTEIGSLNSKGSLGKD
CCCCCCCCCCCCCCC		43.6228833060
421PhosphorylationGSLNSKGSLGKDTTS
CCCCCCCCCCCCCCC		37.3722817900
426PhosphorylationKGSLGKDTTSPMELA
CCCCCCCCCCHHHHH		32.4325521595
427PhosphorylationGSLGKDTTSPMELAA
CCCCCCCCCHHHHHH		40.7525521595
428PhosphorylationSLGKDTTSPMELAAL
CCCCCCCCHHHHHHH		25.0925521595
449PhosphorylationWIKNQDDSLTETDTL
HCCCCCCCCCCCCEE		45.5429899451
479PhosphorylationVVPEKVKTPMKSSKA
ECCCCCCCCCCCCCH		31.44-
491PhosphorylationSKADLQGSASPSKVE
CCHHHCCCCCCCCCC		16.7722942356
493PhosphorylationADLQGSASPSKVEGT
HHHCCCCCCCCCCCC		31.2527087446
495PhosphorylationLQGSASPSKVEGTHT
HCCCCCCCCCCCCCC		47.0022942356
500PhosphorylationSPSKVEGTHTPRQKR
CCCCCCCCCCCCCCC		14.7426824392
502PhosphorylationSKVEGTHTPRQKRST
CCCCCCCCCCCCCCC		21.7226824392
508PhosphorylationHTPRQKRSTPLKERQ
CCCCCCCCCCCCHHH		41.2225266776
509PhosphorylationTPRQKRSTPLKERQL
CCCCCCCCCCCHHHC		36.35-
517PhosphorylationPLKERQLSKPLSERT
CCCHHHCCCCHHHCC		24.7226824392
521PhosphorylationRQLSKPLSERTNSSD
HHCCCCHHHCCCCCC		33.2926643407
524PhosphorylationSKPLSERTNSSDSER
CCCHHHCCCCCCCCC		35.0927087446
526PhosphorylationPLSERTNSSDSERSP
CHHHCCCCCCCCCCC		34.6026824392
527PhosphorylationLSERTNSSDSERSPD
HHHCCCCCCCCCCCC		47.4227087446
529PhosphorylationERTNSSDSERSPDLG
HCCCCCCCCCCCCCC		36.5427087446
532PhosphorylationNSSDSERSPDLGHST
CCCCCCCCCCCCCCC		20.7927087446
538PhosphorylationRSPDLGHSTQIPRKV
CCCCCCCCCCCCHHH		21.8725619855
539PhosphorylationSPDLGHSTQIPRKVV
CCCCCCCCCCCHHHH		25.5025619855
664PhosphorylationFLIIPLGSHPVAKYL
EEEEECCCCHHHHHH		32.0929899451
699PhosphorylationSRSEPPVSEPLDVVG
HCCCCCCCCCHHHHH		38.99-
740PhosphorylationKFPDEDSYQKFIPFI
CCCCHHHHHHHHCEE		28.2229514104
758PhosphorylationKVGLVEDSPSTAGDG
EEEEECCCCCCCCCC		13.7725619855
760PhosphorylationGLVEDSPSTAGDGDD
EEECCCCCCCCCCCC		34.5425619855
761PhosphorylationLVEDSPSTAGDGDDS
EECCCCCCCCCCCCC		37.7425619855
768PhosphorylationTAGDGDDSPVVSLTV
CCCCCCCCCEEEEEE		25.0825619855
772PhosphorylationGDDSPVVSLTVPSTS
CCCCCEEEEEECCCC		20.6825619855
774PhosphorylationDSPVVSLTVPSTSPP
CCCEEEEEECCCCCC		23.9025619855
777PhosphorylationVVSLTVPSTSPPSSS
EEEEEECCCCCCCCC		36.8625619855
778PhosphorylationVSLTVPSTSPPSSSG
EEEEECCCCCCCCCC		38.9025619855
779PhosphorylationSLTVPSTSPPSSSGL
EEEECCCCCCCCCCC		38.8725521595
782PhosphorylationVPSTSPPSSSGLSRD
ECCCCCCCCCCCCCC		40.2925619855
783PhosphorylationPSTSPPSSSGLSRDA
CCCCCCCCCCCCCCC		33.9125619855
784PhosphorylationSTSPPSSSGLSRDAT
CCCCCCCCCCCCCCC		48.3625619855
787PhosphorylationPPSSSGLSRDATATP
CCCCCCCCCCCCCCC		31.4725619855
791PhosphorylationSGLSRDATATPPSSP
CCCCCCCCCCCCCCC		35.0426643407
793PhosphorylationLSRDATATPPSSPSM
CCCCCCCCCCCCCCH		31.2326643407
796PhosphorylationDATATPPSSPSMSSA
CCCCCCCCCCCHHHH		56.9626643407
797PhosphorylationATATPPSSPSMSSAL
CCCCCCCCCCHHHHE		27.1126643407
799PhosphorylationATPPSSPSMSSALAI
CCCCCCCCHHHHEEC		32.9926643407
801PhosphorylationPPSSPSMSSALAIVG
CCCCCCHHHHEECCC		19.4526643407
802PhosphorylationPSSPSMSSALAIVGS
CCCCCHHHHEECCCC		20.7526643407
809PhosphorylationSALAIVGSPNSPYGD
HHEECCCCCCCCCCC		15.2626643407
812PhosphorylationAIVGSPNSPYGDVIG
ECCCCCCCCCCCCEE		23.9226643407
932PhosphorylationSIDGVEWSDIKFFQL
EECCCCHHHHHHHHH		18.8925338131
958PhosphorylationPVGLFSGSKTT----
CCCCCCCCCCC----		26.1529899451
961PhosphorylationLFSGSKTT-------
CCCCCCCC-------		40.1129899451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PACS1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PACS1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PACS1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PACS1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PACS1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28 AND THR-427, AND MASSSPECTROMETRY.
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-249, AND MASSSPECTROMETRY.

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