R3HD2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: R3HD2_MOUSE
• UniProt AC: Q80TM6
• Protein Name: R3H domain-containing protein 2
• Gene Name: R3hdm2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1044
• Subcellular Localization: Nucleus .
• Protein Sequence: MSNSNTTQETLEIMKESEKKLVEESVNKNKFISKTPSKEDVEKEGEENGLRQETQRRTSSHGHARKRAKSNSKLKLVRSLAVCEESSTPFVDGPLDTQDIIQLHISCPSDKEEEKSTKDVSEKEDKDKSKEKVPRKMLSRDSSQEYTDSTGIDLHEFLVNTLKKNPRDRMMLLKLEQEILDFINDNNNQFKKFPQMTSYHRMLLHRVAAYFGMDHNVDQTGKAVIINKTSSTRIPEQRFSEHIKDEKNTEFQQRFILKRDDASMDRDDNQMRVPLQDGRRSKSIEEREEEYQRVRERIFARETGQNGYLNDIRLSKEAFSSSSHKRRQIFRGNREGLSRTSSSRQSSTDSELKSLEPRPWSSTDSDGSVRSMRPPVTKASSFSGISILTRGDSIGSSKGGSAGRLSRPGMALGAPEVCNQVTSPQSVRGLLPCTAQQQQQQQQQQQQLPALPPTPQHQPPLNNHMISQPVPALQPSPQPVQFSPSSCPQVLLPVSPPQQYNMAEDLSNPFGQMSLSRQGSTEAADPSSALFQPPLISQHPQQASFIMASAGQPLPTSNYSTSSHAPPTQQVLPPQGYMQPPQQIQVSYYPPGQYPNSNQQYRPLSHPVAYSPQRGQQLPQASQQPGLQPMMSNQQQTAYQGMLGVQQPQNQGLLSNQRSSMGGQMQGLVVQYTPLPSYQVPVGSDSQNVVQPSFQQPMLVPASQSVQGGLPTGGVPVYYSMIPPAQQNGTSPSVGFLQPPGSEQYQMPQSPSPCSPPQMSQQYSGVSPSGPGVVVMQLNVPNGPQAPQNPSMVQWSHCKYYSVEQRGQKPGDLYSPDGSPQANAQMGSSPVTSPTQSPAPSPVTSLSNVCTGLSPLPVLTPFPRPGGPAQGDGRYSLLGQPLQYNLSICPPLLHGQSTYTVHQGQSGLKHGNRGKRQALKSASTDLGTADVVLGRVLEVTDLPEGITRTEADKLFTQLAMSGAKIQWLKDAQGLPGAGGGDNSGTAENGRHPDLAALYTIVAVFPSPLAAQNASLRLNNSVSRFKLRVAKKNYDLRILERASSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MSNSNTTQETLEI --CCCCCCHHHHHHH	29.67	28576409
7	Phosphorylation	-MSNSNTTQETLEIM -CCCCCCHHHHHHHH	28.76	28576409
10	Phosphorylation	NSNTTQETLEIMKES CCCCHHHHHHHHHHH	21.63	28059163
35	Phosphorylation	KNKFISKTPSKEDVE CCCCCCCCCCHHHHH	26.46	27742792
37	Phosphorylation	KFISKTPSKEDVEKE CCCCCCCCHHHHHHH	54.64	20139300
70	Phosphorylation	HARKRAKSNSKLKLV HHHHHHHCCHHHHHH	45.40	-
139	Phosphorylation	KVPRKMLSRDSSQEY HCCHHHHCCCCCCCC	30.46	22324799
142	Phosphorylation	RKMLSRDSSQEYTDS HHHHCCCCCCCCCCC	32.58	21082442
143	Phosphorylation	KMLSRDSSQEYTDST HHHCCCCCCCCCCCC	31.18	18388127
146	Phosphorylation	SRDSSQEYTDSTGID CCCCCCCCCCCCCCC	14.28	25619855
147	Phosphorylation	RDSSQEYTDSTGIDL CCCCCCCCCCCCCCH	23.79	25619855
149	Phosphorylation	SSQEYTDSTGIDLHE CCCCCCCCCCCCHHH	22.27	26643407
150	Phosphorylation	SQEYTDSTGIDLHEF CCCCCCCCCCCHHHH	40.75	26643407
263 (in isoform 4)	Phosphorylation	-	28.36	29899451
263	Phosphorylation	ILKRDDASMDRDDNQ EEECCCCCCCCCCCC	28.36	25521595
281	Phosphorylation	PLQDGRRSKSIEERE CCCCCCCCCCHHHHH	29.42	25159016
283	Phosphorylation	QDGRRSKSIEEREEE CCCCCCCCHHHHHHH	36.16	25521595
320 (in isoform 3)	Phosphorylation	-	36.04	29514104
320 (in isoform 2)	Phosphorylation	-	36.04	29514104
324 (in isoform 3)	Phosphorylation	-	29.59	29514104
324 (in isoform 2)	Phosphorylation	-	29.59	29514104
338	Phosphorylation	RGNREGLSRTSSSRQ CCCCCCCCCCCCCCC	44.35	-
340	Phosphorylation	NREGLSRTSSSRQSS CCCCCCCCCCCCCCC	29.59	21183079
341	Phosphorylation	REGLSRTSSSRQSST CCCCCCCCCCCCCCC	25.80	29899451
342	Phosphorylation	EGLSRTSSSRQSSTD CCCCCCCCCCCCCCH	29.00	25266776
343	Phosphorylation	GLSRTSSSRQSSTDS CCCCCCCCCCCCCHH	33.82	30635358
346	Phosphorylation	RTSSSRQSSTDSELK CCCCCCCCCCHHHHH	33.81	25521595
347	Phosphorylation	TSSSRQSSTDSELKS CCCCCCCCCHHHHHH	28.09	25521595
348	Phosphorylation	SSSRQSSTDSELKSL CCCCCCCCHHHHHHC	49.11	30635358
361	Phosphorylation	SLEPRPWSSTDSDGS HCCCCCCCCCCCCCC	26.49	25521595
362	Phosphorylation	LEPRPWSSTDSDGSV CCCCCCCCCCCCCCC	32.15	25521595
363	Phosphorylation	EPRPWSSTDSDGSVR CCCCCCCCCCCCCCC	33.72	26239621
365	Phosphorylation	RPWSSTDSDGSVRSM CCCCCCCCCCCCCCC	43.91	25521595
368	Phosphorylation	SSTDSDGSVRSMRPP CCCCCCCCCCCCCCC	21.24	26643407
371	Phosphorylation	DSDGSVRSMRPPVTK CCCCCCCCCCCCCCC	19.58	23737553
377	Phosphorylation	RSMRPPVTKASSFSG CCCCCCCCCCCCCCC	27.02	23737553
380	Phosphorylation	RPPVTKASSFSGISI CCCCCCCCCCCCEEE	33.21	24925903
381	Phosphorylation	PPVTKASSFSGISIL CCCCCCCCCCCEEEE	28.43	25521595
383	Phosphorylation	VTKASSFSGISILTR CCCCCCCCCEEEEEC	36.85	25521595
386	Phosphorylation	ASSFSGISILTRGDS CCCCCCEEEEECCCC	18.31	24925903
389	Phosphorylation	FSGISILTRGDSIGS CCCEEEEECCCCCCC	30.82	28833060
393	Phosphorylation	SILTRGDSIGSSKGG EEEECCCCCCCCCCC	31.50	25521595
396	Phosphorylation	TRGDSIGSSKGGSAG ECCCCCCCCCCCCCC	27.49	26643407
397	Phosphorylation	RGDSIGSSKGGSAGR CCCCCCCCCCCCCCC	30.06	22324799
422	Phosphorylation	PEVCNQVTSPQSVRG HHHHCCCCCCHHHHH	25.56	23984901
423	Phosphorylation	EVCNQVTSPQSVRGL HHHCCCCCCHHHHHH	23.29	26643407
426	Phosphorylation	NQVTSPQSVRGLLPC CCCCCCHHHHHHHHH	19.71	23984901
520	Phosphorylation	MSLSRQGSTEAADPS CCCCCCCCCCCCCCC	18.09	22817900
521	Phosphorylation	SLSRQGSTEAADPSS CCCCCCCCCCCCCCH	36.15	-
605	Phosphorylation	NQQYRPLSHPVAYSP CCCCCCCCCCCCCCC	28.55	28066266
610	Phosphorylation	PLSHPVAYSPQRGQQ CCCCCCCCCCCCCCC	22.55	28066266
611	Phosphorylation	LSHPVAYSPQRGQQL CCCCCCCCCCCCCCC	12.57	28066266
659	Phosphorylation	GLLSNQRSSMGGQMQ CCCCCCCHHCCCCCC	18.21	-
802	Phosphorylation	WSHCKYYSVEQRGQK CCCCEEEEHHHCCCC	18.98	26643407
921	Phosphorylation	GKRQALKSASTDLGT HHHHHHHHCCCCCCH	28.44	25521595
923	Phosphorylation	RQALKSASTDLGTAD HHHHHHCCCCCCHHH	29.55	25521595
924	Phosphorylation	QALKSASTDLGTADV HHHHHCCCCCCHHHH	34.65	25521595
928	Phosphorylation	SASTDLGTADVVLGR HCCCCCCHHHHHHCE	27.29	24925903
1033	Phosphorylation	LRVAKKNYDLRILER HEHHHCCCCHHHHHH	25.82	22324799
1042	Phosphorylation	LRILERASSQ----- HHHHHHHHCC-----	35.18	23984901
1043	Phosphorylation	RILERASSQ------ HHHHHHHCC------	38.64	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of R3HD2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of R3HD2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of R3HD2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of R3HD2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.