DCLK2_MOUSE - dbPTM
DCLK2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DCLK2_MOUSE
UniProt AC Q6PGN3
Protein Name Serine/threonine-protein kinase DCLK2
Gene Name Dclk2
Organism Mus musculus (Mouse).
Sequence Length 756
Subcellular Localization Cytoplasm, cytoskeleton . Colocalizes with microtubules.
Protein Description Protein kinase with a significantly reduced Ca(2+)+/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm..
Protein Sequence MASTRSIELEHFEERDKRPRPGSRRGAPSSSGGSSISGPKGNGLIPSPAHSAHCSFYRTRTLQALSSEKKAKKARFYRNGDRYFKGLVFAISNDRFRSFDALLIELTRSLSDNVNLPQGVRTIYTIDGSRKVTSLDELLEGESYVCASNEPFRKVDYTKNVNPNWSVNIKGGTTRTLAVASAKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTLDGKQVTCLQDFFGDDDVFIACGPEKYRYAQDDFVLDHSECRVLKSSYSRASAAKYSGSRSPGFSRRSKSPASVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKQISAQGRSSSNVNGGPELDRCLSPEGVNGNRCSESFPLLEKYRIGKVIGDGNFAVVKECVDRYTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATDLFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDVWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGEILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEGQIFCSKLCQDSSRPSREQTSPVPPSAQEAPPPLESPRPPGPPATSGCDLAGTWRRHRD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MASTRSIELEHFE
--CCCCCCEEHHHHH		22.0925521595
34PhosphorylationAPSSSGGSSISGPKG
CCCCCCCCCCCCCCC		28.2029899451
35PhosphorylationPSSSGGSSISGPKGN
CCCCCCCCCCCCCCC		24.8529899451
37PhosphorylationSSGGSSISGPKGNGL
CCCCCCCCCCCCCCC		51.4923140645
47PhosphorylationKGNGLIPSPAHSAHC
CCCCCCCCCCHHCCC		27.9424759943
51PhosphorylationLIPSPAHSAHCSFYR
CCCCCCHHCCCCHHH		23.0924759943
55PhosphorylationPAHSAHCSFYRTRTL
CCHHCCCCHHHHHHH		18.5523140645
61PhosphorylationCSFYRTRTLQALSSE
CCHHHHHHHHHHCCH		23.7022942356
67PhosphorylationRTLQALSSEKKAKKA
HHHHHHCCHHHHHHH		55.0422942356
107PhosphorylationDALLIELTRSLSDNV
HHHHHHHHHHHCCCC		12.8618056256
133PhosphorylationIDGSRKVTSLDELLE
ECCCCEECCHHHHHC		26.9729899451
134PhosphorylationDGSRKVTSLDELLEG
CCCCEECCHHHHHCC		36.4929899451
184PhosphorylationLAVASAKSEVKESKD
EEHHHCCHHHHHCCC		47.5429514104
203PhosphorylationKLVTVIRSGVKPRKA
HHHHHHCCCCCHHHH		36.4927149854
219PhosphorylationRILLNKKTAHSFEQV
HHHCCCCCCCCHHHH		31.0825177544
222PhosphorylationLNKKTAHSFEQVLTD
CCCCCCCCHHHHHHH		28.1925177544
292PhosphorylationSECRVLKSSYSRASA
HHHHHHHCCCCHHHH		30.2828066266
293PhosphorylationECRVLKSSYSRASAA
HHHHHHCCCCHHHHH		26.0728066266
295PhosphorylationRVLKSSYSRASAAKY
HHHHCCCCHHHHHHH		24.2620139300
298PhosphorylationKSSYSRASAAKYSGS
HCCCCHHHHHHHCCC		27.8720139300
302PhosphorylationSRASAAKYSGSRSPG
CHHHHHHHCCCCCCC		17.3423527152
305PhosphorylationSAAKYSGSRSPGFSR
HHHHHCCCCCCCCCC		24.5224759943
307PhosphorylationAKYSGSRSPGFSRRS
HHHCCCCCCCCCCCC		30.9522324799
307 (in isoform 3)Phosphorylation-30.9529514104
307 (in isoform 5)Phosphorylation-30.9529514104
307 (in isoform 4)Phosphorylation-30.9529514104
311PhosphorylationGSRSPGFSRRSKSPA
CCCCCCCCCCCCCCC		32.4729899451
314PhosphorylationSPGFSRRSKSPASVN
CCCCCCCCCCCCCCC		36.0525619855
316 (in isoform 3)Phosphorylation-27.2621454597
316 (in isoform 4)Phosphorylation-27.2621454597
316 (in isoform 5)Phosphorylation-27.2621454597
316PhosphorylationGFSRRSKSPASVNGT
CCCCCCCCCCCCCCC		27.2625619855
319PhosphorylationRRSKSPASVNGTPSS
CCCCCCCCCCCCCHH		21.3525619855
330PhosphorylationTPSSQLSTPKSTKSS
CCHHHCCCCCCCCCC		43.24-
333PhosphorylationSQLSTPKSTKSSSSS
HHCCCCCCCCCCCCC		42.1220139300
336PhosphorylationSTPKSTKSSSSSPTS
CCCCCCCCCCCCCCC		35.2223527152
339PhosphorylationKSTKSSSSSPTSPGS
CCCCCCCCCCCCCCC		42.1423527152
340 (in isoform 2)Phosphorylation-33.8629514104
340PhosphorylationSTKSSSSSPTSPGSF
CCCCCCCCCCCCCCC		33.8625521595
342PhosphorylationKSSSSSPTSPGSFRG
CCCCCCCCCCCCCCC		49.8821183079
343 (in isoform 2)Phosphorylation-30.5529514104
343PhosphorylationSSSSSPTSPGSFRGL
CCCCCCCCCCCCCCH		30.5525521595
346 (in isoform 2)Phosphorylation-18.3629514104
346PhosphorylationSSPTSPGSFRGLKQI
CCCCCCCCCCCHHHE		18.3629899451
356 (in isoform 3)Phosphorylation-40.8329514104
356 (in isoform 5)Phosphorylation-40.8329514104
359 (in isoform 3)Phosphorylation-44.9629514104
359PhosphorylationQISAQGRSSSNVNGG
HEECCCCCCCCCCCC		44.9623527152
359 (in isoform 5)Phosphorylation-44.9629514104
360PhosphorylationISAQGRSSSNVNGGP
EECCCCCCCCCCCCC		25.2726160508
360 (in isoform 2)Phosphorylation-25.2729514104
361PhosphorylationSAQGRSSSNVNGGPE
ECCCCCCCCCCCCCC		46.1523527152
362 (in isoform 3)Phosphorylation-32.9729514104
362 (in isoform 5)Phosphorylation-32.9729514104
374PhosphorylationPELDRCLSPEGVNGN
CCCCCCCCCCCCCCC		25.2422324799
376 (in isoform 3)Phosphorylation-72.8429514104
376 (in isoform 5)Phosphorylation-72.8429514104
628PhosphorylationDSAKELISQMLQVNV
HHHHHHHHHHHHCCH		23.3522871156
646PhosphorylationCTAGEILSHPWVSDD
CCCCHHHCCCCCCCC		32.92-
665PhosphorylationNNMQAEVTGKLKQHF
CCHHHHHHHHHHHHH		21.80-
681PhosphorylationNALPKQNSTTTGVSV
HCCCCCCCCCCCCEE		25.3328066266
682PhosphorylationALPKQNSTTTGVSVI
CCCCCCCCCCCCEEE		35.6128066266
683PhosphorylationLPKQNSTTTGVSVIM
CCCCCCCCCCCEEEE		22.7528066266
684PhosphorylationPKQNSTTTGVSVIMN
CCCCCCCCCCEEEEC		35.3628066266
687PhosphorylationNSTTTGVSVIMNTAL
CCCCCCCEEEECCCC		13.7929899451
711DimethylationKLCQDSSRPSREQTS
HHCCCCCCCCCHHCC		36.85-
717PhosphorylationSRPSREQTSPVPPSA
CCCCCHHCCCCCCCH		30.1925338131
718PhosphorylationRPSREQTSPVPPSAQ
CCCCHHCCCCCCCHH		24.4825338131
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DCLK2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DCLK2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DCLK2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of DCLK2_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DCLK2_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6, AND MASSSPECTROMETRY.

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