EDC3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EDC3_MOUSE
• UniProt AC: Q8K2D3
• Protein Name: Enhancer of mRNA-decapping protein 3
• Gene Name: Edc3
• Organism: Mus musculus (Mouse).
• Sequence Length: 508
• Subcellular Localization: Cytoplasm, P-body. Processing bodies (PB)..
• Protein Description: Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping (By similarity)..
• Protein Sequence: MAMDWLGSIVSINCGDSLGVYQGRVSAVDQVSQTISLTRPFHNGVKCLVPEVTFRAGDITELKILEIPGPGDNQQVGDLHQTELGPSGVGYQMSISQNGTGKVVKKPASSSSAPQSIPKRTDVKSQDVAISPQQQQCSKSYVDRHMESLSQSKSFRRRHNSWSSSSRHPNQATPKKSGLKNGQMKNKDDECFGDDIEELPDTDFDFEGNLALFDKAAVFEEIDTYERRSGSRSRGVPNERPARYRHDENILESEPIVYRRITVPHSVSKEFCTDSGLVVPSVSYELHKKLLSVAEKHGLTLERRLEMTGVCASQMALTLLGGPNRLNPKNVHQRPTVALLCGPHVKGAQGISCGRHLANHDVQVILFLPNFVKMLESITNELSLFSKTQGQQVSSLRDLPASPVDLVINCLDCPENAFLRDQPWYKAAVAWANQNRAPVLSIDPPVHEVEQGIDAKWSLALGLPLPLGEHAGRVYLCDIGIPQQVFQEVGINYHSPFGCKFVIPLHSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAMDWLGSIVSINCG CCCCCCCCEEEEECC	20.04	25293948
11	Phosphorylation	DWLGSIVSINCGDSL CCCCCEEEEECCCCC	13.35	25293948
17	Phosphorylation	VSINCGDSLGVYQGR EEEECCCCCEECCCC	16.59	25293948
21	Phosphorylation	CGDSLGVYQGRVSAV CCCCCEECCCCEEEH	11.94	25293948
26	Phosphorylation	GVYQGRVSAVDQVSQ EECCCCEEEHHHHHC	22.63	29895711
109	Phosphorylation	KVVKKPASSSSAPQS CEEECCCCCCCCCCC	39.00	25338131
116	Phosphorylation	SSSSAPQSIPKRTDV CCCCCCCCCCCCCCC	39.54	25266776
125	Phosphorylation	PKRTDVKSQDVAISP CCCCCCCCCCCCCCH	31.31	25619855
131	Phosphorylation	KSQDVAISPQQQQCS CCCCCCCCHHHHHHC	13.61	27087446
138	Phosphorylation	SPQQQQCSKSYVDRH CHHHHHHCHHHHHHH	21.94	25619855
140	Phosphorylation	QQQQCSKSYVDRHME HHHHHCHHHHHHHHH	17.69	23429704
141	Phosphorylation	QQQCSKSYVDRHMES HHHHCHHHHHHHHHH	15.31	23429704
148	Phosphorylation	YVDRHMESLSQSKSF HHHHHHHHHHCCHHH	26.25	28066266
150	Phosphorylation	DRHMESLSQSKSFRR HHHHHHHHCCHHHHH	41.51	28066266
152	Phosphorylation	HMESLSQSKSFRRRH HHHHHHCCHHHHHHH	27.22	28066266
154	Phosphorylation	ESLSQSKSFRRRHNS HHHHCCHHHHHHHCC	29.27	25266776
161	Phosphorylation	SFRRRHNSWSSSSRH HHHHHHCCCCCCCCC	23.39	25521595
163	Phosphorylation	RRRHNSWSSSSRHPN HHHHCCCCCCCCCCC	21.84	25159016
164	Phosphorylation	RRHNSWSSSSRHPNQ HHHCCCCCCCCCCCC	26.52	25159016
165	Phosphorylation	RHNSWSSSSRHPNQA HHCCCCCCCCCCCCC	26.35	25159016
166	Phosphorylation	HNSWSSSSRHPNQAT HCCCCCCCCCCCCCC	36.23	25159016
173	Phosphorylation	SRHPNQATPKKSGLK CCCCCCCCCCCCCCC	26.36	26745281
225	Phosphorylation	VFEEIDTYERRSGSR HEEECCCCCCCCCCC	12.04	26026062
229	Phosphorylation	IDTYERRSGSRSRGV CCCCCCCCCCCCCCC	47.55	-
231	Phosphorylation	TYERRSGSRSRGVPN CCCCCCCCCCCCCCC	28.47	22871156
258	Phosphorylation	LESEPIVYRRITVPH CCCCCEEEEEEECCC	8.56	-
377	Phosphorylation	NFVKMLESITNELSL HHHHHHHHHHHHHHH	30.65	29895711
383	Phosphorylation	ESITNELSLFSKTQG HHHHHHHHHHHCCCC	22.61	29895711
386	Phosphorylation	TNELSLFSKTQGQQV HHHHHHHHCCCCCCC	39.83	29895711

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EDC3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EDC3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EDC3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of EDC3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.