CAPR1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAPR1_MOUSE
• UniProt AC: Q60865
• Protein Name: Caprin-1
• Gene Name: Caprin1
• Organism: Mus musculus (Mouse).
• Sequence Length: 707
• Subcellular Localization: Cytoplasm, cytosol. Cell projection, dendrite. Associated with RNA granules..
• Protein Description: May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. [PubMed: 20516077 Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (By similarity]
• Protein Sequence: MPSATSHSGSGSKSSGPPPPSGSSGSEAAAGAAAPASQHPATGTGAVQTEAMKQILGVIDKKLRNLEKKKGKLDDYQERMNKGERLNQDQLDAVSKYQEVTNNLEFAKELQRSFMALSQDIQKTIKKTARREQLMREEAEQKRLKTVLELQYVLDKLGDDDVRTDLKQGLSGVPILSEEELSLLDEFYKLVDPERDMSLRLNEQYEHASIHLWDLLEGKEKPVCGTTYKALKEIVERVFQSNYFDSTHNHQNGLCEEEEAASAPTVEDQVAEAEPEPAEEYTEQSEVESTEYVNRQFMAETQFSSGEKEQVDEWTVETVEVVNSLQQQPQAASPSVPEPHSLTPVAQSDPLVRRQRVQDLMAQMQGPYNFIQDSMLDFENQTLDPAIVSAQPMNPTQNMDMPQLVCPQVHSESRLAQSNQVPVQPEATQVPLVSSTSEGYTASQPLYQPSHATEQRPQKEPMDQIQATISLNTDQTTASSSLPAASQPQVFQAGTSKPLHSSGINVNAAPFQSMQTVFNMNAPVPPANEPETLKQQSQYQATYNQSFSSQPHQVEQTELQQDQLQTVVGTYHGSQDQPHQVPGNHQQPPQQNTGFPRSSQPYYNSRGVSRGGSRGARGLMNGYRGPANGFRGGYDGYRPSFSNTPNSGYSQSQFTAPRDYSGYQRDGYQQNFKRGSGQSGPRGAPRGRGGPPRPNRGMPQMNTQQVN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MPSATSHSG ------CCCCCCCCC	32.44	-
6	Phosphorylation	--MPSATSHSGSGSK --CCCCCCCCCCCCC	18.51	27841257
8	Phosphorylation	MPSATSHSGSGSKSS CCCCCCCCCCCCCCC	34.13	27841257
10	Phosphorylation	SATSHSGSGSKSSGP CCCCCCCCCCCCCCC	42.80	-
14	Phosphorylation	HSGSGSKSSGPPPPS CCCCCCCCCCCCCCC	42.07	26643407
15	Phosphorylation	SGSGSKSSGPPPPSG CCCCCCCCCCCCCCC	60.08	26643407
21	Phosphorylation	SSGPPPPSGSSGSEA CCCCCCCCCCCHHHH	58.02	26643407
23	Phosphorylation	GPPPPSGSSGSEAAA CCCCCCCCCHHHHHH	35.54	26643407
24	Phosphorylation	PPPPSGSSGSEAAAG CCCCCCCCHHHHHHH	50.27	26643407
26	Phosphorylation	PPSGSSGSEAAAGAA CCCCCCHHHHHHHCC	26.47	26643407
29	Ubiquitination	GSSGSEAAAGAAAPA CCCHHHHHHHCCCCH	11.46	27667366
37	Phosphorylation	AGAAAPASQHPATGT HHCCCCHHHCCCCCC	28.15	25777480
42	Phosphorylation	PASQHPATGTGAVQT CHHHCCCCCCCHHHH	39.46	25777480
44	Phosphorylation	SQHPATGTGAVQTEA HHCCCCCCCHHHHHH	20.01	25777480
49	Phosphorylation	TGTGAVQTEAMKQIL CCCCHHHHHHHHHHH	21.07	25777480
61	Ubiquitination	QILGVIDKKLRNLEK HHHHHHHHHHHHHHH	42.45	22790023
72	Acetylation	NLEKKKGKLDDYQER HHHHHCCCHHHHHHH	58.59	23806337
72	Ubiquitination	NLEKKKGKLDDYQER HHHHHCCCHHHHHHH	58.59	22790023
108	Ubiquitination	TNNLEFAKELQRSFM HHHHHHHHHHHHHHH	65.36	22790023
113	Phosphorylation	FAKELQRSFMALSQD HHHHHHHHHHHHHHH	13.35	-
123	Acetylation	ALSQDIQKTIKKTAR HHHHHHHHHHHHHHH	53.18	19844979
123	Ubiquitination	ALSQDIQKTIKKTAR HHHHHHHHHHHHHHH	53.18	22790023
126	Ubiquitination	QDIQKTIKKTARREQ HHHHHHHHHHHHHHH	49.67	22790023
126	Acetylation	QDIQKTIKKTARREQ HHHHHHHHHHHHHHH	49.67	19844989
152	Nitration	KTVLELQYVLDKLGD HHHHHHHHHHHHHCC	18.66	-
163	Methylation	KLGDDDVRTDLKQGL HHCCCHHHHHHHHCC	29.53	24129315
167	Ubiquitination	DDVRTDLKQGLSGVP CHHHHHHHHCCCCCC	45.17	-
221	Ubiquitination	DLLEGKEKPVCGTTY HHHCCCCCCCCCCHH	46.35	22790023
224	S-nitrosylation	EGKEKPVCGTTYKAL CCCCCCCCCCHHHHH	5.63	20925432
224	S-nitrosocysteine	EGKEKPVCGTTYKAL CCCCCCCCCCHHHHH	5.63	-
290	Phosphorylation	EQSEVESTEYVNRQF CHHCCCCCHHHCHHH	20.17	-
301	Phosphorylation	NRQFMAETQFSSGEK CHHHHHEECCCCCCC	25.94	25521595
304	Phosphorylation	FMAETQFSSGEKEQV HHHEECCCCCCCCCC	27.84	25521595
305	Phosphorylation	MAETQFSSGEKEQVD HHEECCCCCCCCCCC	52.86	25521595
315	Phosphorylation	KEQVDEWTVETVEVV CCCCCEEEEEEHHHH	13.35	23140645
318	Phosphorylation	VDEWTVETVEVVNSL CCEEEEEEHHHHHHH	20.03	23140645
324	Phosphorylation	ETVEVVNSLQQQPQA EEHHHHHHHHHCCCC	18.88	23140645
333	Phosphorylation	QQQPQAASPSVPEPH HHCCCCCCCCCCCCC	22.26	23140645
335	Phosphorylation	QPQAASPSVPEPHSL CCCCCCCCCCCCCCC	48.05	23140645
341	Phosphorylation	PSVPEPHSLTPVAQS CCCCCCCCCCCCCCC	44.66	23649490
343	Phosphorylation	VPEPHSLTPVAQSDP CCCCCCCCCCCCCCH	20.80	20139300
348	Phosphorylation	SLTPVAQSDPLVRRQ CCCCCCCCCHHHHHH	31.30	23140645
437	Phosphorylation	VPLVSSTSEGYTASQ CCCEEECCCCCCCCC	30.85	-
447	Phosphorylation	YTASQPLYQPSHATE CCCCCCCCCCCCCCC	25.68	22817900
453	Phosphorylation	LYQPSHATEQRPQKE CCCCCCCCCCCCCCC	27.51	24224561
539	Phosphorylation	TLKQQSQYQATYNQS HHHHHHHHHHHHCCC	12.83	22817900
543	Phosphorylation	QSQYQATYNQSFSSQ HHHHHHHHCCCCCCC	17.77	22817900
606	Dimethylation	SQPYYNSRGVSRGGS CCCCCCCCCCCCCCC	45.99	-
606	Methylation	SQPYYNSRGVSRGGS CCCCCCCCCCCCCCC	45.99	-
610	Dimethylation	YNSRGVSRGGSRGAR CCCCCCCCCCCCCHH	51.60	-
614	Dimethylation	GVSRGGSRGARGLMN CCCCCCCCCHHHHCC	46.17	-
617	Dimethylation	RGGSRGARGLMNGYR CCCCCCHHHHCCCCC	41.42	-
624	Methylation	RGLMNGYRGPANGFR HHHCCCCCCCCCCCC	46.12	-
628	Phosphorylation	NGYRGPANGFRGGYD CCCCCCCCCCCCCCC	53.95	19144319
631	Dimethylation	RGPANGFRGGYDGYR CCCCCCCCCCCCCCC	38.74	-
631	Methylation	RGPANGFRGGYDGYR CCCCCCCCCCCCCCC	38.74	24129315
634	Phosphorylation	ANGFRGGYDGYRPSF CCCCCCCCCCCCCCC	14.71	-
638	Methylation	RGGYDGYRPSFSNTP CCCCCCCCCCCCCCC	26.39	24129315
640	Phosphorylation	GYDGYRPSFSNTPNS CCCCCCCCCCCCCCC	32.10	28066266
642	Phosphorylation	DGYRPSFSNTPNSGY CCCCCCCCCCCCCCC	44.10	28066266
644	Phosphorylation	YRPSFSNTPNSGYSQ CCCCCCCCCCCCCCH	23.73	28066266
647	Phosphorylation	SFSNTPNSGYSQSQF CCCCCCCCCCCHHHC	40.07	28066266
649	Phosphorylation	SNTPNSGYSQSQFTA CCCCCCCCCHHHCCC	11.89	25367039
650	Phosphorylation	NTPNSGYSQSQFTAP CCCCCCCCHHHCCCC	27.21	25367039
660	Phosphorylation	QFTAPRDYSGYQRDG HCCCCCCCCCCCCCC	12.79	22817900
665	Methylation	RDYSGYQRDGYQQNF CCCCCCCCCCCCCCC	30.73	-
668	Phosphorylation	SGYQRDGYQQNFKRG CCCCCCCCCCCCCCC	15.94	25367039
679	Phosphorylation	FKRGSGQSGPRGAPR CCCCCCCCCCCCCCC	55.05	19144319
696	Asymmetric dimethylarginine	GGPPRPNRGMPQMNT CCCCCCCCCCCCCCC	45.53	-
696	Methylation	GGPPRPNRGMPQMNT CCCCCCCCCCCCCCC	45.53	24129315

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAPR1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAPR1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAPR1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CAPR1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.