INP5E_MOUSE - dbPTM
INP5E_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID INP5E_MOUSE
UniProt AC Q9JII1
Protein Name 72 kDa inositol polyphosphate 5-phosphatase
Gene Name Inpp5e
Organism Mus musculus (Mouse).
Sequence Length 647
Subcellular Localization Cytoplasm, cytoskeleton, cilium axoneme . Golgi apparatus, Golgi stack membrane
Peripheral membrane protein
Cytoplasmic side . Cell projection, ruffle . Cell membrane
Peripheral membrane protein
Cytoplasmic side . Cytoplasm . Peripheral membr
Protein Description Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Specific for lipid substrates, inactive towards water soluble inositol phosphates..
Protein Sequence MPSKSACLRHTEAPGQLEGRMLQGQPPNTEKKLIPTPGFLPASDSQGSETNPMPPFSIPAKTSNQNPQTKANLITPQPPIRPKLERTLSLDDKGWRRRRFRGSQEDLTVQNGASPCRGSLQDSVAQSPAYSRPLPCLSTSLQEIPKSRRATGSEGGSPSLWSDCLSGMISTSLDLLHRDAASGGPPSRLASLHASHTPPAMDLSIASSSLRTANKVDPEHTDYKLRMQTRLVRAHSNLGPSRPRSPLAGDDHSIHSARSFSLLAPIRTKDIRSRSYLEGSLLASGALLGAEELARYFPDRNMALFVATWNMQGQKELPASLDEFLLPTEADYTQDLYVIGIQEGCSDRREWETRLQETLGPQYVLLSSAAHGVLYMSLFIRRDLIWFCSEVEYSTVTTRIVSQIKTKGALGVSFTFFGTSFLFITSHFTSGDGKVAERLLDYSRTIQALALPRNVPDTNPYRSSAGDVTTRFDEVFWFGDFNFRLSGGRVAVEAFLKQKPEVDVLALLQHDQLTREMKKGSIFRGFEEAEIHFLPSYKFDIGKDTYDSTSKQRTPSYTDRVLYKSRHKGDICPMKYSSCPGIKTSDHRPVYGLFQVKVRPGRDNIPLAAGKFDRELYLIGIKRRISKEIQRQEALKSQSSSAVCTVS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
29PhosphorylationLQGQPPNTEKKLIPT
CCCCCCCCCCCCCCC		55.7621659604
36PhosphorylationTEKKLIPTPGFLPAS
CCCCCCCCCCCCCCC		29.1125159016
43PhosphorylationTPGFLPASDSQGSET
CCCCCCCCCCCCCCC		35.5425159016
45PhosphorylationGFLPASDSQGSETNP
CCCCCCCCCCCCCCC		33.6725159016
48PhosphorylationPASDSQGSETNPMPP
CCCCCCCCCCCCCCC		33.3425159016
50PhosphorylationSDSQGSETNPMPPFS
CCCCCCCCCCCCCCC		46.4425159016
57PhosphorylationTNPMPPFSIPAKTSN
CCCCCCCCCCCCCCC		33.1725159016
87PhosphorylationIRPKLERTLSLDDKG
CCCCCEEEECCCCCC		16.0122324799
89PhosphorylationPKLERTLSLDDKGWR
CCCEEEECCCCCCCH		29.1925521595
93AcetylationRTLSLDDKGWRRRRF
EEECCCCCCCHHHHC		61.106568345
103PhosphorylationRRRRFRGSQEDLTVQ
HHHHCCCCHHHCEEC		26.5825521595
108PhosphorylationRGSQEDLTVQNGASP
CCCHHHCEECCCCCC		32.1629899451
114PhosphorylationLTVQNGASPCRGSLQ
CEECCCCCCCCCCCC		26.4025777480
119PhosphorylationGASPCRGSLQDSVAQ
CCCCCCCCCCCHHCC		11.9625777480
123PhosphorylationCRGSLQDSVAQSPAY
CCCCCCCHHCCCCCC		13.3425777480
127PhosphorylationLQDSVAQSPAYSRPL
CCCHHCCCCCCCCCC		11.1925777480
130PhosphorylationSVAQSPAYSRPLPCL
HHCCCCCCCCCCCCC		14.4825777480
131PhosphorylationVAQSPAYSRPLPCLS
HCCCCCCCCCCCCCC		29.5425777480
138PhosphorylationSRPLPCLSTSLQEIP
CCCCCCCCCCHHHCC		23.7526643407
139PhosphorylationRPLPCLSTSLQEIPK
CCCCCCCCCHHHCCH		22.1026643407
140PhosphorylationPLPCLSTSLQEIPKS
CCCCCCCCHHHCCHH		25.3626643407
153PhosphorylationKSRRATGSEGGSPSL
HHHCCCCCCCCCHHH		28.8126643407
157PhosphorylationATGSEGGSPSLWSDC
CCCCCCCCHHHHHHH		23.3626643407
159PhosphorylationGSEGGSPSLWSDCLS
CCCCCCHHHHHHHHH		44.1426643407
191PhosphorylationGPPSRLASLHASHTP
CCHHHHHHHHHCCCC		25.8626643407
195PhosphorylationRLASLHASHTPPAMD
HHHHHHHCCCCCCCC		19.6926643407
197PhosphorylationASLHASHTPPAMDLS
HHHHHCCCCCCCCHH		28.5926643407
208PhosphorylationMDLSIASSSLRTANK
CCHHHHHHHCCCCCC		25.1128059163
209PhosphorylationDLSIASSSLRTANKV
CHHHHHHHCCCCCCC		21.2628059163
236PhosphorylationTRLVRAHSNLGPSRP
HHHHHHHCCCCCCCC		32.5326824392
241PhosphorylationAHSNLGPSRPRSPLA
HHCCCCCCCCCCCCC		53.7926824392
245PhosphorylationLGPSRPRSPLAGDDH
CCCCCCCCCCCCCCC		27.2726824392
253PhosphorylationPLAGDDHSIHSARSF
CCCCCCCCCCCCCCE		29.0528833060
256PhosphorylationGDDHSIHSARSFSLL
CCCCCCCCCCCEEEE		24.5728833060
259PhosphorylationHSIHSARSFSLLAPI
CCCCCCCCEEEECEE		20.9227180971
261PhosphorylationIHSARSFSLLAPIRT
CCCCCCEEEECEECC		24.5829472430
637PhosphorylationQRQEALKSQSSSAVC
HHHHHHHHCCCCCEE		35.8221183079
640PhosphorylationEALKSQSSSAVCTVS
HHHHHCCCCCEEECC		18.0621183079
644MethylationSQSSSAVCTVS----
HCCCCCEEECC----		2.88-
644FarnesylationSQSSSAVCTVS----
HCCCCCEEECC----		2.88-
647PhosphorylationSSAVCTVS-------
CCCEEECC-------		19.1521183079
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of INP5E_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of INP5E_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of INP5E_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of INP5E_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of INP5E_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245, AND MASSSPECTROMETRY.

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