ATAT_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATAT_MOUSE
• UniProt AC: Q8K341
• Protein Name: Alpha-tubulin N-acetyltransferase 1 {ECO:0000255|HAMAP-Rule:MF_03130}
• Gene Name: Atat1 {ECO:0000255|HAMAP-Rule:MF_03130}
• Organism: Mus musculus (Mouse).
• Sequence Length: 421
• Subcellular Localization: Cytoplasm . Membrane, clathrin-coated pit . Cell junction, focal adhesion . Cell projection, axon . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, spindle . In primary root dorsal ganglion neurons, localizes with acetylated tubulin in axons. Recr
• Protein Description: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly..
• Protein Sequence: MEFPFDVDALFPERITVLDQHLRPPARRPGTTTPARVDLQQQIMTIVDELGKASAKAQHLPAPITSALRMQSNRHVIYILKDTSARPAGKGAIIGFLKVGYKKLFVLDDREAHNEVEPLCILDFYIHESVQRHGHGRELFQHMLQKERVEPHQLAIDRPSPKLLKFLNKHYNLETTVPQVNNFVIFEGFFAHQHRPPTSSLRATRHSRAAVADPIPAAPARKLPPKRAEGDIKPYSSSDREFLKVAVEPPWPLNRAPRRATPPAHPPPRSSSLGNSPDRGPLRPFVPEQELLRSLRLCPPHPTARLLLATDPGGSPAQRRRTRGTPWGLVAQSCHYSRHGGFNTSFLGTGNQERKQGEQEAEDRSASEDRVLLLDGSGEEPTQTGAPRAQAPPPQSWTVGGDIMNARVIRNLQERRSTRPW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	PPARRPGTTTPARVD CCCCCCCCCCCCCHH	30.13	29899451
33	Phosphorylation	ARRPGTTTPARVDLQ CCCCCCCCCCCHHHH	18.13	29899451
56	Acetylation	ELGKASAKAQHLPAP HHHHHHHHHHCCCCC	46.19	23275437
56 (in isoform 2)	Acetylation	-	46.19	-
90	Acetylation	TSARPAGKGAIIGFL CCCCCCCCCCEEEEE	47.47	19843487
90	Ubiquitination	TSARPAGKGAIIGFL CCCCCCCCCCEEEEE	47.47	-
146	Acetylation	LFQHMLQKERVEPHQ HHHHHHHHCCCCHHH	43.45	23275437
146 (in isoform 2)	Acetylation	-	43.45	-
210 (in isoform 2)	Acetylation	-	8.91	-
221 (in isoform 2)	Acetylation	-	39.73	-
233	Acetylation	KRAEGDIKPYSSSDR CCCCCCCCCCCCCCH	42.51	23806337
244	Acetylation	SSDREFLKVAVEPPW CCCHHHHEEEECCCC	33.21	23275437
261	Phosphorylation	NRAPRRATPPAHPPP CCCCCCCCCCCCCCC	28.17	30372032
270	Phosphorylation	PAHPPPRSSSLGNSP CCCCCCCCCCCCCCC	30.01	21659605
271	Phosphorylation	AHPPPRSSSLGNSPD CCCCCCCCCCCCCCC	30.75	26160508
272	Phosphorylation	HPPPRSSSLGNSPDR CCCCCCCCCCCCCCC	41.35	26824392
276	Phosphorylation	RSSSLGNSPDRGPLR CCCCCCCCCCCCCCC	26.78	26824392
283	Methylation	SPDRGPLRPFVPEQE CCCCCCCCCCCCHHH	26.24	-
287 (in isoform 5)	Phosphorylation	-	37.62	29514104
292 (in isoform 5)	Phosphorylation	-	3.26	29514104
293	Methylation	VPEQELLRSLRLCPP CCHHHHHHHCCCCCC	46.39	-
296	Dimethylation	QELLRSLRLCPPHPT HHHHHHCCCCCCCCC	35.18	-
300 (in isoform 5)	Phosphorylation	-	45.13	29514104
301 (in isoform 5)	Phosphorylation	-	19.93	25338131
305	Methylation	CPPHPTARLLLATDP CCCCCCEEEEEEECC	28.48	24129315
305	Asymmetric dimethylarginine	CPPHPTARLLLATDP CCCCCCEEEEEEECC	28.48	-
310 (in isoform 4)	Phosphorylation	-	42.57	29514104
310	Phosphorylation	TARLLLATDPGGSPA CEEEEEEECCCCCHH	42.57	23527152
310 (in isoform 5)	Phosphorylation	-	42.57	29899451
315 (in isoform 4)	Phosphorylation	-	23.99	29514104
315	Phosphorylation	LATDPGGSPAQRRRT EEECCCCCHHHHCCC	23.99	25521595
323 (in isoform 4)	Phosphorylation	-	45.22	29514104
323	Methylation	PAQRRRTRGTPWGLV HHHHCCCCCCCCHHH	45.22	-
324 (in isoform 4)	Phosphorylation	-	35.20	25338131
333 (in isoform 4)	Phosphorylation	-	7.98	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATAT_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATAT_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATAT_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ATAT_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.