TBCD7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBCD7_MOUSE
• UniProt AC: Q9D0K0
• Protein Name: TBC1 domain family member 7
• Gene Name: Tbc1d7
• Organism: Mus musculus (Mouse).
• Sequence Length: 293
• Subcellular Localization: Cytoplasmic vesicle. Localizes in the cytoplasmic vesicles of the endomembrane in association with TSC1-TSC2 complex..
• Protein Description: Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question..
• Protein Sequence: MTDDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDRLDIEKLCTFSQRFPLPSMYRALVWKALLGILPPHHDTHSQVMAYRKDQYHDILHALTVVRFISDATPQAEVYLRMYQLESGKLPRSPSFPLEPEDEVFLAIAKAMEEMVEDSVDCYWISRCFVKQLNNKYRDALPQLPKAFEQYLNLEDSRLLSHLKTCSAVSKLPYDLWFQRCFAGCLPESSLQRVWDKVVSGSCKILVFVAVEILLTFKIKVMALNSAEKITKFLENIPQDSSDAIVSKAIDLWHKHCGTPVHSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
122	Phosphorylation	ESGKLPRSPSFPLEP CCCCCCCCCCCCCCC	23.98	29899451
124	Phosphorylation	GKLPRSPSFPLEPED CCCCCCCCCCCCCHH	40.52	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TBCD7_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBCD7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBCD7_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AT2A2_HUMAN	ATP2A2	physical	26496610
MCAT_HUMAN	SLC25A20	physical	26496610
CSPG4_HUMAN	CSPG4	physical	26496610
TSC1_HUMAN	TSC1	physical	26496610
TSC2_HUMAN	TSC2	physical	26496610
MBD4_HUMAN	MBD4	physical	26496610
PTTG1_HUMAN	PTTG1	physical	26496610
LC7L2_HUMAN	LUC7L2	physical	26496610
HEAT3_HUMAN	HEATR3	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.