TBCD7_MOUSE - dbPTM
TBCD7_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TBCD7_MOUSE
UniProt AC Q9D0K0
Protein Name TBC1 domain family member 7
Gene Name Tbc1d7
Organism Mus musculus (Mouse).
Sequence Length 293
Subcellular Localization Cytoplasmic vesicle. Localizes in the cytoplasmic vesicles of the endomembrane in association with TSC1-TSC2 complex..
Protein Description Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question..
Protein Sequence MTDDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDRLDIEKLCTFSQRFPLPSMYRALVWKALLGILPPHHDTHSQVMAYRKDQYHDILHALTVVRFISDATPQAEVYLRMYQLESGKLPRSPSFPLEPEDEVFLAIAKAMEEMVEDSVDCYWISRCFVKQLNNKYRDALPQLPKAFEQYLNLEDSRLLSHLKTCSAVSKLPYDLWFQRCFAGCLPESSLQRVWDKVVSGSCKILVFVAVEILLTFKIKVMALNSAEKITKFLENIPQDSSDAIVSKAIDLWHKHCGTPVHSA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
122PhosphorylationESGKLPRSPSFPLEP
CCCCCCCCCCCCCCC
23.9829899451
124PhosphorylationGKLPRSPSFPLEPED
CCCCCCCCCCCCCHH
40.5229899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TBCD7_MOUSE !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TBCD7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TBCD7_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AT2A2_HUMANATP2A2physical
26496610
MCAT_HUMANSLC25A20physical
26496610
CSPG4_HUMANCSPG4physical
26496610
TSC1_HUMANTSC1physical
26496610
TSC2_HUMANTSC2physical
26496610
MBD4_HUMANMBD4physical
26496610
PTTG1_HUMANPTTG1physical
26496610
LC7L2_HUMANLUC7L2physical
26496610
HEAT3_HUMANHEATR3physical
26496610

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TBCD7_MOUSE

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Related Literatures of Post-Translational Modification

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