UniProt ID | TBCD7_MOUSE | |
---|---|---|
UniProt AC | Q9D0K0 | |
Protein Name | TBC1 domain family member 7 | |
Gene Name | Tbc1d7 | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 293 | |
Subcellular Localization | Cytoplasmic vesicle. Localizes in the cytoplasmic vesicles of the endomembrane in association with TSC1-TSC2 complex.. | |
Protein Description | Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.. | |
Protein Sequence | MTDDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDRLDIEKLCTFSQRFPLPSMYRALVWKALLGILPPHHDTHSQVMAYRKDQYHDILHALTVVRFISDATPQAEVYLRMYQLESGKLPRSPSFPLEPEDEVFLAIAKAMEEMVEDSVDCYWISRCFVKQLNNKYRDALPQLPKAFEQYLNLEDSRLLSHLKTCSAVSKLPYDLWFQRCFAGCLPESSLQRVWDKVVSGSCKILVFVAVEILLTFKIKVMALNSAEKITKFLENIPQDSSDAIVSKAIDLWHKHCGTPVHSA | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
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Oops, there are no upstream regulatory protein records of TBCD7_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
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Oops, there are no descriptions of PTM sites of TBCD7_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TBCD7_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
AT2A2_HUMAN | ATP2A2 | physical | 26496610 | |
MCAT_HUMAN | SLC25A20 | physical | 26496610 | |
CSPG4_HUMAN | CSPG4 | physical | 26496610 | |
TSC1_HUMAN | TSC1 | physical | 26496610 | |
TSC2_HUMAN | TSC2 | physical | 26496610 | |
MBD4_HUMAN | MBD4 | physical | 26496610 | |
PTTG1_HUMAN | PTTG1 | physical | 26496610 | |
LC7L2_HUMAN | LUC7L2 | physical | 26496610 | |
HEAT3_HUMAN | HEATR3 | physical | 26496610 |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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