dbPTM

MCAT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MCAT_HUMAN
UniProt AC	O43772
Protein Name	Mitochondrial carnitine/acylcarnitine carrier protein
Gene Name	SLC25A20
Organism	Homo sapiens (Human).
Sequence Length	301
Subcellular Localization	Mitochondrion inner membrane Multi-pass membrane protein.
Protein Description	Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway..
Protein Sequence	MADQPKPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLSGVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKFLNWATPNL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADQPKPIS ------CCCCCCCCC	24.93	25944712
9	Phosphorylation	ADQPKPISPLKNLLA CCCCCCCCHHHHHHC	32.48	29255136
124	Phosphorylation	GMLSGVFTTGIMTPG HHHCCCEECCCCCCH	23.00	-
143	Phosphorylation	CLLQIQASSGESKYT EEEEEEECCCCCCCE	23.62	25072903
144	Phosphorylation	LLQIQASSGESKYTG EEEEEECCCCCCCEE	49.98	25072903
147	Phosphorylation	IQASSGESKYTGTLD EEECCCCCCCEEEHH	34.19	25072903
148	Acetylation	QASSGESKYTGTLDC EECCCCCCCEEEHHH	42.39	-
157	Acetylation	TGTLDCAKKLYQEFG EEEHHHHHHHHHHHC	50.03	-
157	Ubiquitination	TGTLDCAKKLYQEFG EEEHHHHHHHHHHHC	50.03	-
166	Methylation	LYQEFGIRGIYKGTV HHHHHCCCCEEECCE	26.32	115917069
169	Phosphorylation	EFGIRGIYKGTVLTL HHCCCCEEECCEEEE	13.24	-
170	Acetylation	FGIRGIYKGTVLTLM HCCCCEEECCEEEEE	46.30	-
170	Succinylation	FGIRGIYKGTVLTLM HCCCCEEECCEEEEE	46.30	-
170	Succinylation	FGIRGIYKGTVLTLM HCCCCEEECCEEEEE	46.30	-
183	Phosphorylation	LMRDVPASGMYFMTY EEECCCCCCEEEEEH	20.30	27251275
186	Phosphorylation	DVPASGMYFMTYEWL CCCCCCEEEEEHHHH	8.17	27251275
189	Phosphorylation	ASGMYFMTYEWLKNI CCCEEEEEHHHHHHH	14.37	27251275
190	Phosphorylation	SGMYFMTYEWLKNIF CCEEEEEHHHHHHHC	8.04	27251275
198	Phosphorylation	EWLKNIFTPEGKRVS HHHHHHCCCCCCCHH	19.34	27251275
205	Phosphorylation	TPEGKRVSELSAPRI CCCCCCHHHCCCCEE	36.53	20833797
208	Phosphorylation	GKRVSELSAPRILVA CCCHHHCCCCEEEEE	31.98	24719451
244	Ubiquitination	FQTAPPGKYPNGFRD HCCCCCCCCCCCHHH	64.41	22817900
244	Acetylation	FQTAPPGKYPNGFRD HCCCCCCCCCCCHHH	64.41	25038526

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MCAT_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MCAT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MCAT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
ESR1_HUMAN	ESR1	physical	23178685

Drug and Disease Associations

Kegg Disease
H00525	Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficien
OMIM Disease
212138	Carnitine-acylcarnitine translocase deficiency (CACTD)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00583	L-Carnitine

Regulatory Network of MCAT_HUMAN

Related Literatures of Post-Translational Modification