GIT2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GIT2_MOUSE
• UniProt AC: Q9JLQ2
• Protein Name: ARF GTPase-activating protein GIT2
• Gene Name: Git2
• Organism: Mus musculus (Mouse).
• Sequence Length: 708
• Protein Description: GTPase-activating protein for the ADP ribosylation factor family..
• Protein Sequence: MSKRLRSSDVCADCNGPDPSWASVNRGTFICDECCSVHRSLGRHISQVRHLKHTAWPPTLLQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCREDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGSTPLHVASKAGQILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLIEIQYELTDRLAFYLCGRKPDHKSGQHFLIPQRADSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLATQNHSTLVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGSPLSRSKDNVELILRTVSTQHSTESQDNDQPDYDSVASDEDTDVETRASKANRQKLQTLQSENSSLRRQATASACQVQTGSDHKDTASHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEASHPEESRTRLQPFPTHIGRSALVTSSSSLPSFPSTLSWSRDESARRASRLEKQNSTPESDYDNTACDPEPDDTGSTRKGRQRSMLWQGDGLLPDTAEPHSVPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDTVRTSLRLLTSSAYRLQSECRKALPGDSSLPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKENSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MSKRLRSSDVCADC -CCCCCCCCCCCCCC	35.17	19060867
20	Phosphorylation	DCNGPDPSWASVNRG CCCCCCCCHHCCCCC	42.53	25338131
23	Phosphorylation	GPDPSWASVNRGTFI CCCCCHHCCCCCEEE	17.42	25338131
224	Phosphorylation	ERLIEIQYELTDRLA HHHHHHHHHHHHHHH	20.68	-
255	Phosphorylation	LIPQRADSLDLSELA EECCCCCCCCHHHHH	23.85	27180971
285	Phosphorylation	EELAMDVYDEVDRRE HHHHHHHHHHHHHHH	11.34	-
343	Phosphorylation	FNAHEFATLVIDILS HCHHHHHHHHHHHHH	27.21	21183079
359	Phosphorylation	AKRRQQGSPLSRSKD HHHHHCCCCCCCCCC	20.52	25521595
362	Phosphorylation	RQQGSPLSRSKDNVE HHCCCCCCCCCCHHE	37.58	25521595
374	Phosphorylation	NVELILRTVSTQHST HHEEEEEEHHCCCCC	18.50	25619855
376	Phosphorylation	ELILRTVSTQHSTES EEEEEEHHCCCCCCC	23.03	25619855
377	Phosphorylation	LILRTVSTQHSTESQ EEEEEHHCCCCCCCC	26.43	25619855
380	Phosphorylation	RTVSTQHSTESQDND EEHHCCCCCCCCCCC	24.85	25619855
381	Phosphorylation	TVSTQHSTESQDNDQ EHHCCCCCCCCCCCC	37.22	25619855
383	Phosphorylation	STQHSTESQDNDQPD HCCCCCCCCCCCCCC	42.81	25619855
391	Phosphorylation	QDNDQPDYDSVASDE CCCCCCCCCCCCCCC	19.46	27087446
393	Phosphorylation	NDQPDYDSVASDEDT CCCCCCCCCCCCCCC	17.22	27087446
396	Phosphorylation	PDYDSVASDEDTDVE CCCCCCCCCCCCCHH	39.10	27087446
400	Phosphorylation	SVASDEDTDVETRAS CCCCCCCCCHHHHHH	39.64	18515860
404	Phosphorylation	DEDTDVETRASKANR CCCCCHHHHHHHHHH	31.23	25619855
419	Phosphorylation	QKLQTLQSENSSLRR HHHHHHHHHCHHHHH	41.69	29472430
422	Phosphorylation	QTLQSENSSLRRQAT HHHHHHCHHHHHHHH	27.05	24704852
423	Phosphorylation	TLQSENSSLRRQATA HHHHHCHHHHHHHHH	37.16	29472430
429	Phosphorylation	SSLRRQATASACQVQ HHHHHHHHHHHCEEE	16.89	27600695
431	Phosphorylation	LRRQATASACQVQTG HHHHHHHHHCEEECC	25.81	26824392
437	Phosphorylation	ASACQVQTGSDHKDT HHHCEEECCCCCCCC	39.53	-
446	Phosphorylation	SDHKDTASHSSLKRR CCCCCCCCCHHHCCC	26.45	29550500
448	Phosphorylation	HKDTASHSSLKRRPS CCCCCCCHHHCCCCC	34.57	24899341
449	Phosphorylation	KDTASHSSLKRRPSA CCCCCCHHHCCCCCC	32.27	25266776
455	Phosphorylation	SSLKRRPSARGSRPM HHHCCCCCCCCCCCC	28.87	20531401
459	Phosphorylation	RRPSARGSRPMSMYE CCCCCCCCCCCCEEE	27.88	25266776
463	Phosphorylation	ARGSRPMSMYETGSG CCCCCCCCEEECCCC	22.39	30352176
465	Phosphorylation	GSRPMSMYETGSGQK CCCCCCEEECCCCCC	11.75	24224561
467	Phosphorylation	RPMSMYETGSGQKPY CCCCEEECCCCCCCC	21.11	25367039
469	Phosphorylation	MSMYETGSGQKPYLP CCEEECCCCCCCCCC	45.53	25367039
474	Phosphorylation	TGSGQKPYLPMGEAS CCCCCCCCCCCCCCC	30.39	29514104
500	O-linked_Glycosylation	FPTHIGRSALVTSSS CCCCCCCCEEEECCC	22.27	30059200
500	Phosphorylation	FPTHIGRSALVTSSS CCCCCCCCEEEECCC	22.27	23737553
504	Phosphorylation	IGRSALVTSSSSLPS CCCCEEEECCCCCCC	24.60	26745281
505	Phosphorylation	GRSALVTSSSSLPSF CCCEEEECCCCCCCC	22.27	26745281
506	Phosphorylation	RSALVTSSSSLPSFP CCEEEECCCCCCCCC	18.00	26745281
507	Phosphorylation	SALVTSSSSLPSFPS CEEEECCCCCCCCCC	35.34	21082442
508	Phosphorylation	ALVTSSSSLPSFPST EEEECCCCCCCCCCC	46.37	22942356
511	Phosphorylation	TSSSSLPSFPSTLSW ECCCCCCCCCCCCCC	55.90	21082442
514	Phosphorylation	SSLPSFPSTLSWSRD CCCCCCCCCCCCCCC	39.71	26745281
515	Phosphorylation	SLPSFPSTLSWSRDE CCCCCCCCCCCCCCH	25.67	26745281
517	Phosphorylation	PSFPSTLSWSRDESA CCCCCCCCCCCCHHH	24.08	23737553
519	Phosphorylation	FPSTLSWSRDESARR CCCCCCCCCCHHHHH	26.86	21082442
523	Phosphorylation	LSWSRDESARRASRL CCCCCCHHHHHHHHH	31.22	23984901
528	Phosphorylation	DESARRASRLEKQNS CHHHHHHHHHHHHCC	35.27	29472430
535	Phosphorylation	SRLEKQNSTPESDYD HHHHHHCCCCCHHCC	42.73	25521595
536	Phosphorylation	RLEKQNSTPESDYDN HHHHHCCCCCHHCCC	38.33	24723360
539	Phosphorylation	KQNSTPESDYDNTAC HHCCCCCHHCCCCCC	42.55	22499769
541	Phosphorylation	NSTPESDYDNTACDP CCCCCHHCCCCCCCC	22.00	25521595
544	Phosphorylation	PESDYDNTACDPEPD CCHHCCCCCCCCCCC	26.26	22499769
553	Phosphorylation	CDPEPDDTGSTRKGR CCCCCCCCCCCCHHC	40.17	22499769
555	Phosphorylation	PEPDDTGSTRKGRQR CCCCCCCCCCHHCCH	27.42	22499769
556	Phosphorylation	EPDDTGSTRKGRQRS CCCCCCCCCHHCCHH	37.43	22499769
563	Phosphorylation	TRKGRQRSMLWQGDG CCHHCCHHHCEECCC	15.19	26824392
575	Phosphorylation	GDGLLPDTAEPHSVP CCCCCCCCCCCCCCC	30.86	23984901
580	Phosphorylation	PDTAEPHSVPSPTLP CCCCCCCCCCCCCCC	46.57	23984901
583	Phosphorylation	AEPHSVPSPTLPSTE CCCCCCCCCCCCCHH	28.50	22942356
585	Phosphorylation	PHSVPSPTLPSTEDV CCCCCCCCCCCHHHH	56.49	21189417
596	Phosphorylation	TEDVIRKTEQITKNI HHHHHHHHHHHHHHH	24.23	20495213
617	Phosphorylation	AQENKHDSYIPCSER HHHCCCCCCCCHHHH	25.36	25266776
618	Phosphorylation	QENKHDSYIPCSERI HHCCCCCCCCHHHHH	18.23	30635358
622	Phosphorylation	HDSYIPCSERIHVAV CCCCCCHHHHHHHHH	25.26	30635358
700	Phosphorylation	KAAKQLVTITTKENS HHHHHHHEEEECCCC	22.62	28576409
707	Phosphorylation	TITTKENSS------ EEEECCCCC------	38.22	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GIT2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GIT2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GIT2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GIT2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-396; THR-400 ANDSER-535, AND MASS SPECTROMETRY.
PubMed: 17242355